Publications by authors named "Yolanda Arce"
Article Synopsis
- Acute myeloid leukemia (AML) is usually not linked to secondary hemolytic-uremic syndrome (HUS), but this case report presents an exception.
- A woman diagnosed with AML developed severe HUS, and her condition improved significantly after receiving eculizumab, a medication that helped stabilize her health.
- After one year with normal renal function and genetic tests, she was able to stop eculizumab, underscoring the importance of early treatment for secondary HUS in improving patient outcomes.
Purpose: We evaluated the prevalence of homologous recombination deficiencies (HRD) to determine the efficacy of different techniques and clinical characteristics of patients.
Methods: This retrospective study included patients with metastatic prostate cancer who underwent molecular testing at our hospital between 2016 and 2022. We used tumor tissue, ctDNA, and lymphocytes for somatic or germline testing.
Fabry disease or also called Anderson-Fabry disease (FD) is a rare disease caused by pathogenic variants in the GLA gene, located on the X chromosome. This gene is involved in the metabolism of glycosphingolipids and its pathogenic variants cause a deficit or absence of α-galactosidase A causing the deposition of globotriaosylceramide throughout the body. Females have a variable phenotypic expression and a better prognosis than males.
View Article and Find Full Text PDFRationale & Objective: Alport syndrome is a common genetic kidney disease accounting for approximately 2% of patients receiving kidney replacement therapy (KRT). It is caused by pathogenic variants in the gene COL4A3, COL4A4, or COL4A5. The aim of this study was to evaluate the clinical and genetic spectrum of patients with autosomal dominant Alport syndrome (ADAS).
View Article and Find Full Text PDFThere are many variants of urothelial carcinoma. One of the most infrequent is formed by cells with a lipid content and an adipose tissue appearance. Only 43 cases have been reported in the bladder, 2 in the renal pelvis and 1 case in the ureter.
View Article and Find Full Text PDFMonoclonal gammopathy of renal significance includes all renal disorders caused by a monoclonal immunoglobulin secreted by a non-malignant B-cell clone. Patients with MGRS do not, by definition, meet criteria for multiple myeloma, with haematological disorders generally considered to be monoclonal gammopathy of undetermined significance. Nevertheless, the renal involvement can be serious and require specific treatment.
View Article and Find Full Text PDFBackground And Objectives: Several studies have suggested that activation of the complement system is a contributing pathogenic mechanism in IgA nephropathy (IgAN). C4d staining is an inexpensive and easy-to-perform method for the analysis of renal biopsies. This study aimed to assess the clinical and prognostic implications of C4d staining in IgAN.
View Article and Find Full Text PDFThe long-term outcome of patients with IgA nephropathy who present with normal renal function, microscopic hematuria, and minimal or no proteinuria is not well described. Here, we studied 141 Caucasian patients with biopsy-proven IgA nephropathy who had minor abnormalities at presentation and a median follow-up of 108 months. None of the patients received corticosteroids or immunosuppressants.
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- * A case study showed acute renal failure in a PNH patient, who had significant haemosiderin deposits in kidney tubules and strong immunostaining for the CD163 receptor.
- * The findings indicate that free haemoglobin may contribute to kidney damage through oxidative stress in PNH, suggesting its role in tubulointerstitial injury.
Hypertrophy of human mesangial cells (HMC) is among the earliest characteristics in patients with diabetic nephropathy (DN). Recently, we observed the upregulation of parathyroid hormone (PTH)-related protein (PTHrP) in experimental DN, associated with renal hypertrophy. Herein, we first examined whether PTHrP was overexpressed in human DN, and next assessed the putative role of this protein on high glucose (HG)-induced HMC hypertrophy.
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- * The study focuses on the role of equilibrative nucleoside transporter 1 (ENT1), which is crucial for adenosine transport, in the EMT process of human proximal tubular cells.
- * Findings indicate that higher levels of ENT1 promote cell protection during EMT, while its reduction leads to increased collagen production and vulnerability to renal fibrosis.
Natural history of prostatic carcinoma: the pathologist's perspective.
Recent Results Cancer Res
May 2007
Article Synopsis
- The stem cells in prostate acini are thought to be where prostate cancer starts, with various intermediate cells capable of becoming cancerous, leading to different forms of the disease.
- Prostatic intraepithelial neoplasia (PIN) is viewed as a precursor to prostate cancer, and its detection in biopsies helps doctors monitor patients.
- Understanding how prostate cancer invades surrounding tissue and the related molecular changes can improve prognostic assessments, especially when combined with traditional grading systems like Gleason.
We evaluated the performance of a multiprobe FISH (fluorescence in situ hybridization) assay for noninvasive detection of superficial urothelial carcinoma (UC) in the bladder, in comparison to urinary cytology. Voided urine samples from 74 patients with superficial UC were analyzed by both techniques. Urine samples from 19 patients with muscle-invasive tumors and from 19 healthy control subjects were also studied.
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- * As the Gleason grade of prostate cancer increases, there is a notable loss of E-cadherin expression, with abnormal levels seen in 35% of lower grades versus 75% in higher grades, suggesting its potential as a prognostic marker.
- * Understanding the regulation of adhesion molecules like E-cadherin could be vital for exploring new therapeutic strategies in cancer treatment, given their interconnected role in various cell control pathways.
Background: This study ascertained the effect of S-adenosyl-L-methionine (SAMe) administration on the ischemia-reperfusion injury associated with pig liver transplantation from non-heart-beating donors (NHBDs) after prolonged warm ischemia.
Method: Twenty-five animals underwent transplantation with an allograft from an NHBD. After donor cardiac arrest, cardiopulmonary bypass and normothermic recirculation (NR) were performed for 30 min.