Insights and trends review: Use of extended reality (xR) in hand surgery.

Digital transformation through extended reality (xR)-comprising virtual, augmented, mixed, and substitutional reality-has become an integral part of the future of clinical and surgical practice. xR technologies facilitate advanced surgical planning, training, therapies and education, reshaping both personal and institutional healthcare. This paper examines the potential changes that xR has introduced into the field of hand surgery, exploring how xR enhances patient-centric care, increases medical service efficiency and revolutionizes surgical training, planning and therapeutic interventions.

Relationship between insertions of the tibialis anterior and peroneus longus and first tarsometatarsal joint degeneration.

Background: The purpose of this study was to clarify the relationships of the tibialis anterior tendon (TAT) and peroneus longus tendon (PLT) with articular cartilage degeneration on the medial cuneiform and first metatarsal.

Methods: We examined 100 feet from 50 Japanese cadavers. The TAT was classified into 4 types based on attachment site area and number of fiber bundles: Type I, two fiber bundles with equal (within 20%) attachment site areas on the first metatarsal and medial cuneiform; Type II, with two fiber bundles and a larger (>20%) attachment site area on the medial cuneiform than on the first metatarsal; Type III, with two fiber bundles and a larger (>20%) attachment site area on the first metatarsal than on the medial cuneiform; and Type IV, with three fiber bundles.

Changes in glenohumeral range of motion by repetitive pitching and their relationship with arm speed during pitching.

This study aimed to (1) examine the acute changes in the glenohumeral range of motion (ROM) after repetitive pitching and (2) clarify whether arm speed during pitching is associated with changes in the glenohumeral internal rotation (IR) and horizontal adduction (HADd) ROM. Fifteen healthy college males with over five years of baseball experience participated. Glenohumeral ROMs of IR, external rotation, and HADd were measured using a digital inclinometer before, immediately after, and one day after completing 100 repetitive full-effort pitches.

INFLUENCE OF FOVEAL GLIAL TISSUE AFTER MACULAR HOLE SURGERY ON OUTER RETINAL RESTORATION AND VISUAL ACUITY.

Purpose: To investigate the impact of foveal glial tissue on the anatomical and functional results after macular hole (MH) surgery.

Methods: This study included 141 consecutive eyes that underwent successful vitrectomy for full-thickness MH between January 2015 and December 2022. The best-corrected visual acuity and the length of outer retinal defects were evaluated preoperatively and at 6 months postoperatively.

Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway.

Chimeric antigen receptor (CAR) T cell is a promising therapy for cancer, but factors that enhance the efficacy of CAR T cell remain elusive. Here we perform a genome-wide CRISPR screening to probe genes that regulate the proliferation and survival of CAR T cells following repetitive antigen stimulations. We find that genetic ablation of CUL5, encoding a core element of the multi-protein E3 ubiquitin-protein ligase complex, cullin-RING ligase 5, enhances human CD19 CAR T cell expansion potential and effector functions, potentially via the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway.

Precursor-free synthesis of carbon quantum dots and carbon microparticles in supercritical acetone.

Carbon quantum dots (CQDs) have recently received a lot of attention due to their unique physical properties, and their environmentally friendly features such as low toxicity and high biocompatibility. Supercritical fluids, which possess unusual properties such as high solubility, high diffusivity, low viscosity and zero surface tension, are now commonly used particularly in the fields of electronic, chemical and materials science and engineering. Here, we synthesise carbon nano/microparticles in supercritical acetone, in which neither external molecules nor starting materials are dissolved/dispersed.

Translation and Cross-cultural Adaptation of the Kerlan-Jobe Orthopaedic Clinic Shoulder and Elbow Score Into Japanese and Comparison of Visual Analog Scale and 10-Point Scale Formats.

Background: The Kerlan-Jobe Orthopaedic Clinic shoulder and elbow score (KJOC) is sensitive enough to detect subtle changes in the functional level of the shoulder or elbow in overhead athletes. However, a Japanese version of the KJOC is not yet available. Moreover, the original KJOC uses a visual analog scale (VAS) assessment format that requires a print version so that users can add a check mark along a horizontal line.

Artificial intelligence-based personalized survival prediction using clinical and radiomics features in patients with advanced non-small cell lung cancer.

Background: Multiple first-line treatment options have been developed for advanced non-small cell lung cancer (NSCLC) in each subgroup determined by predictive biomarkers, specifically driver oncogene and programmed cell death ligand-1 (PD-L1) status. However, the methodology for optimal treatment selection in individual patients is not established. This study aimed to develop artificial intelligence (AI)-based personalized survival prediction model according to treatment selection.

Evaluation of fatigue, load and the quality of chest compressions by bystanders in hot and humid environments.

Background: This study aimed to investigate the physiological load on bystanders during cardiopulmonary resuscitation (CPR) and the quality of chest compressions in hot and humid environments.

Methods: This prospective experimental study compared the physical load and quality of chest compressions among healthy volunteers who performed 10 min chest compression in a climate chamber under normal conditions (for Tokyo) (Wet Bulb Globe Temperature [WBGT] 21 °C) and hot and humid conditions (WBGT 31 °C). The primary outcome was the depth of chest compressions over a 10-minute period.

Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice.

Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice.

Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6-0.

Mechanotransduction pathways regulating YAP nuclear translocation under Yoda1 and vibration in osteocytes.

Yes-associated protein (YAP) is a mechanosensitive protein crucial for bone remodeling. Although research has identified pathways and components involved in YAP regulation, the precise mechanisms of its localization during Piezo1 activation or vibration remain unclear. Piezo1, a mechanosensitive ion channel, allows calcium ions to flow into cells upon activation.

Cemiplimab monotherapy in Japanese patients with recurrent or metastatic cervical cancer.

Background: In the phase 3 EMPOWER-Cervical 1/GOG-3016/ENGOT-cx9 study, cemiplimab significantly improved overall survival (OS) versus chemotherapy for patients with recurrent or metastatic cervical cancer who progressed after first-line platinum-based chemotherapy. We present a post hoc subgroup analysis of patients enrolled in Japan.

Methods: Patients were enrolled regardless of programmed cell death-ligand 1 status and randomized 1:1 to cemiplimab 350 mg intravenously every 3 weeks or investigator's choice  single-agent chemotherapy for up to 96 weeks.

Supraspinal Activation Induced by Visual Kinesthetic Illusion Modulates Spinal Excitability.

Repetitive passive movement (RPM) enhances reciprocal inhibition. RPM is more effective when performed rapidly and at wide joint angles. However, patients with limited joint range of motion may not receive the most effective RPM.

Brain morphometric changes in children born as small for gestational age without catch up growth.

Introduction: Most infants born as small for gestational age (SGA) demonstrate catch up growth by 2-4 years, but some fail to do so. This failure is associated with several health risks, including neuropsychological development issues. However, data on the morphological characteristics of the brains of infants born as SGA without achieving catch up growth are lacking.

Long-Term Outcome of Eltrombopag With First-Line Immunosuppressive Therapy for Newly Diagnosed Severe Aplastic Anemia.

Background: To investigate whether the addition of eltrombopag (EPAG) to rabbit anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) for newly diagnosed severe aplastic anemia (SAA) improves outcomes and affects the cumulative incidence of clonal evolution (CE), we conducted a multicenter retrospective analysis.

Methods: Data were collected from 101 patients, aged 15 - 65 years, undergoing initial IST.

Results: No significant imbalance in age, sex, or severity was observed between the EPAG (n = 20) and non-EPAG (n = 81) groups.

Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report.

Background: Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced constipation (OIC). It is contraindicated for patients with known or suspected gastrointestinal obstruction to protect against naldemedine-induced perforation. Here, we report a clinical case of suspected perforation of a diverticulum in the sigmoid colon associated with naldemedine.

Dynamic chest radiographic evaluation of the effects of tiotropium/olodaterol combination therapy in chronic obstructive pulmonary disease: the EMBODY study protocol for an open-label, prospective, single-centre, non-controlled, comparative study.

Introduction: To date, there is limited evidence on the effects of bronchodilators on respiratory dynamics in chronic obstructive pulmonary disease (COPD). Dynamic chest radiography (DCR) is a novel radiographic modality that provides real-time, objective and quantifiable kinetic data, including changes in the lung area (Rs), tracheal diameter, diaphragmatic kinetics and pulmonary ventilation during respiration, at a lower radiation dose than that used by fluoroscopic or CT imaging. However, the therapeutic effect of dual bronchodilators on respiratory kinetics, such as chest wall dynamics and respiratory muscle function, has not yet been prospectively evaluated using DCR.

Computed tomography angiography assessment of Adamkiewicz artery with sublingual nitroglycerin administration.

Purpose: Identification of the Adamkiewicz artery before aortic surgery is important for preventing postoperative complications due to spinal cord ischemia. The Adamkiewicz artery is difficult to identify due to its small diameter. Nitroglycerin has a vasodilatory effect and is used clinically to improve visualization of blood vessels on coronary computed tomography (CT) angiography.