Publications by authors named "Yokokawa M"
Background: To improve the prognosis of clinically resectable type 4 or large type 3 gastric cancer (GC), we performed a phase I/II study of neoadjuvant-radiotherapy combined with S-1 plus cisplatin.
Patients And Methods: Phase I, with a standard 3 + 3 dose-escalation design, was performed to define the recommended phase II dose. Efficacy and safety were evaluated in phase II.
Background: Arrhythmias originating from papillary muscles (PAPs) can be challenging when targeted with catheter ablation. The prevalence and impact of structural abnormalities on PAPs in patients with focal PAP arrhythmias is unknown.
Objectives: The purpose of this study was to analyze, in a consecutive patient series with focal PAP arrhythmias, the impact of structural abnormalities detected by multimodality imaging.
Purpose The prognosis for type 4 and large type 3 gastric cancer (GC) is extremely poor, especially in elderly patients (≥ 75 years). To improve the prognosis of these types of GC, we performed a phase I study to determine the recommended dose (RD) of S-1 combined with neoadjuvant radiotherapy. Methods Patients with clinically resectable type 4 and large type 3 GC were enrolled to successive cohorts in a conventional 3 + 3 design.
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- - Dofetilide, a class III antiarrhythmic, is used to treat atrial fibrillation and flutter, and has been applied off-label for ventricular arrhythmias like PVCs and VTs.
- - In a study involving 81 patients, dofetilide initiation showed a significant decrease in PVC burden, but was discontinued in some cases due to QT prolongation and lack of efficacy.
- - Overall, 72% of patients had to stop dofetilide due to inefficacy or intolerance, and there was no significant difference in event-free survival between those treated with dofetilide and those who weren't.
Background: Patients may develop atrial tachycardia (AT) after left atrial (LA) ablation of persistent atrial fibrillation (AF).
Methods: The population consisted of 101 consecutive patients (age = 64.3 ± 8.
Background: Patients with arrhythmias originating from papillary muscles (PAPs) often have pleomorphic ventricular arrhythmias (PVAs) that can result in failed ablations. The mechanism of PVAs is unknown.
Objective: The purpose of this study was to assess the prevalence and mechanisms of PVAs and the impact on outcomes in patients with focal left ventricular PAP ventricular arrhythmias (VAs).
Article Synopsis
- Immune checkpoint inhibitors (ICIs), specifically c4G12, show promise in treating various advanced malignant tumors in dogs, including osteosarcoma and nasal adenocarcinoma, based on a clinical study conducted at Hokkaido University.
- The study involved 12 dogs, with a treatment regimen of c4G12 administered bi-weekly, revealing a significant incidence of treatment-related adverse effects in 8 dogs, though most were manageable.
- The results indicate a 25% objective response rate among dogs with measurable disease, highlighting the need for further research to better understand which tumor types respond best to this treatment.
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene. The establishment of effective newborn screening (NBS) for SMA is important for early diagnosis so that treatment can be administered in the pre-symptomatic or early disease stages. Polymerase chain reaction (PCR)-based genetic testing with dried blood spots has been used in NBS to detect the homozygous deletion of exon 7 in SMN1, however, this methodology is not able to detect newborn infants with heterozygous deletions and/or point mutations in SMN1.
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- - The study focused on how the anatomy of papillary muscles (PAPs) relates to the mapping and successful ablation of ventricular arrhythmias (VAs) in patients.
- - Among 43 patients with frequent PAP arrhythmias, 40% had VAs originating from connections between PAPs and the surrounding myocardium, showing distinct electrocardiographic patterns.
- - Results indicated that patients with a higher number of PAP-myocardial connections (PAP-MYCs) had higher failure rates during ablation procedures, highlighting the importance of detailed anatomical imaging in treatment success.
Article Synopsis
- Immune checkpoint inhibitors (ICIs), like the anti-PD-L1 antibody, have shown limited effectiveness in treating canine malignant melanoma.
- Recent research on humans indicates that combining radiation therapy (RT) with ICIs can enhance systemic antitumor immunity.
- This study found that hypofractionated RT followed by anti-PD-L1 therapy showed improved clinical benefits and overall survival in dogs, particularly for those who had previous RT, suggesting this combination might be a promising treatment strategy with manageable side effects.
Purpose: To investigate the risk of bladder cancer (BCa) in patients treated with brachytherapy for prostate cancer (PCa).
Methods: We retrospectively analyzed 583 patients with PCa who underwent brachytherapy with or without external beam radiotherapy (EBRT). We analyzed the disease-free survival (DFS) of BCa in patients with PCa who underwent brachytherapy with or without EBRT.
Article Synopsis
- The study investigates the unintended isolation of the left atrial appendage (LAA) during radiofrequency ablation for persistent atrial fibrillation (AF) and its impact on long-term thromboembolic risk.
- It involved analyzing 41 patients with incidental LAA isolation and comparing thromboembolic occurrences to a matched group of 82 patients without such isolation over an average follow-up of 4.2 years.
- Results showed that patients with LAA isolation had a significantly higher rate of thromboembolism (17%) compared to those without (4%), highlighting the need to consider the risks of LAA isolation in treatment plans.
Article Synopsis
- Monitored anesthesia care (MAC) and general anesthesia (GA) are two methods used during catheter ablation for atrial fibrillation (AF), each with its own pros and cons.
- A study involving 810 patients found no significant differences in complications or long-term outcomes between MAC and GA, although GA resulted in longer anesthesia times and slightly higher costs.
- Ultimately, both methods showed similar effectiveness and safety in achieving sinus rhythm post-ablation when proper anesthesiology protocols were followed.
Introduction: Ventricular tachycardia (VT) in structurally normal hearts or nonischemic cardiomyopathy can originate from the aortic sinuses of Valsalva (SoV). It is unknown whether VT can originate from the SoVs in patients with prior myocardial infarction (MI).
Objective: To evaluate the prevalence, arrhythmogenic substrate, and ablation outcomes of postinfarction VT originating from the SoVs.
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety, complexity, and heterogeneity, it is sometimes challenging to make the accurate diagnosis. Here, we report a literature review of EMC of the MSGs with our experience of two cases.
View Article and Find Full Text PDFThe aim of this study is to report the differences in clinicopathological features of oral tongue squamous cell carcinoma (OTSCC) and survival between adolescent and young adult (AYA) patients and elderly patients and to find the prognosticators. The medical records of 101 AYA patients and 175 control patients with OTSCC who underwent surgery were reviewed. Variables related to prognosis and their clinicopathological associations were analyzed.
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- * Out of 113 patients treated, 45% had their AF successfully terminated, with some also showing improvements in areas like the right atrium (RA).
- * On average, 78% of patients remained free from AF after 24 months without needing antiarrhythmic medications, suggesting the method's effectiveness.
Purpose: This study aims to assess the usefulness of diffusion tensor imaging (DTI) as a noninvasive method for the evaluation of histological grade and lymph node metastasis in patients with oral carcinoma (OC).
Materials And Methods: Thirty-six consecutive patients with histologically confirmed OC underwent examination by 3-T MRI. DTI was performed using a single-shot echo-planar imaging sequence with b values of 0 and 1000 s/mm and motion-probing gradients in 12 noncollinear directions.
Background: Metastasis of renal cell carcinoma to the oral cavity is rare. Renal cell carcinoma metastases are regarded as radioresistant tumors and surgery is recommended. However, since metastatic renal cell carcinoma has poor prognosis and is composed of abundant blood vessels, it is sometimes difficult for clinicians to choose surgical therapy.
View Article and Find Full Text PDFAims: Catheter ablation is an effective treatment for post-infarction ventricular tachycardia (VT). However, some patients may experience a worsened arrhythmia phenotype after ablation. We aimed to determine the prevalence and prognostic impact of arrhythmia exacerbation (AE) after post-infarction VT ablation.
View Article and Find Full Text PDFBackground: Frequent premature ventricular complexes (PVCs) can result in PVC-induced cardiomyopathy (PICM). Scarring has been described in patients with frequent PVCs in the absence of apparent heart disease and in patients with known cardiomyopathy.
Objective: The purpose of this study was to determine the impact of focal myocardial scarring as detected by cardiac magnetic resonance imaging (CMR) on PICM, procedural outcomes, and recovery of left ventricular function in patients with frequent PVCs.
Background: Granulocyte colony-stimulating factor (G-CSF) is a cytokine produced in inflammatory environments that induces differentiation and proliferation of neutrophils in bone marrow. We report a rare case of aggressive G-CSF-producing squamous cell carcinoma of the tongue exhibiting fluorine-18 deoxyglucose (FDG) accumulation in primary lesion, metastatic lymph nodes, spleen, and bone marrow on positron emission tomography-computed tomography (PET/CT).
Case Summary: We report a 58-year-old female with a rapid enlarged lingual mass with partial necrosis.
Objectives: The goal of this study was to assess the value of a stepwise, image-guided ablation approach in patients with cardiomyopathy and predominantly intramural scar.
Background: Few reports have focused on catheter-based ventricular tachycardia (VT) ablation strategies in patients with predominantly intramural scar.
Methods: The study included patients with predominantly intramural scar undergoing VT ablation.
Article Synopsis
- Patients with nonischemic cardiomyopathy (NICM) often have heart issues that need treatment, but accessing the right area can be tricky.
- This study looked at a method using the coronary venous system (CVS) to help treat these patients instead of going through more complicated areas.
- Results showed that in some patients, treatment within the CVS helped fix the heart issue without needing extra procedures, especially if the damaged area was close to the CVS.
Background: Fibro-inflammatory processes in the extracellular matrix are closely associated with progressive structural remodeling in atrial fibrillation (AF). Serum concentrations of tenascin-C (TNC), an extracellular matrix glycoprotein, and of high-sensitivity C-reactive protein (CRP) might serve as a marker of remodeling and progressive inflammation of the aorta and in myocardial diseases. This study aimed to clarify relationships between TNC and CRP in patients with AF.
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