Publications by authors named "Yoko Suzuki"

Aim: The aim of this study was to investigate autonomic nervous system imbalance in schizophrenia by comparing heart rate variability (HRV) between patients with schizophrenia and healthy controls, and to assess changes in HRV in patients before and after electroconvulsive therapy (ECT).

Methods: HRV was compared between patients with schizophrenia ( = 17) and age- and gender-matched healthy controls ( = 34). Changes in HRV were also assessed in patients pre- and post-ECT.

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Binaural beats can entrain neural oscillations and modulate behavioral states. However, the effect of binaural beats, particularly those with slow frequencies (< 1 Hz), on sleep remains poorly understood. We hypothesized that 0.

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  • - In-home automated scoring systems for sleep stages are in high demand but face challenges in clinical settings due to issues with electrode contact and limited measurable signals, leading to inaccurate scores.
  • - A new method using an ensemble of small scoring models that utilize different input signal sets can significantly improve scoring accuracy and reduce the impact of electrode contact problems, showing an 8.3 point improvement in accuracy for problematic signals.
  • - This approach not only enhances overall scoring accuracy but also effectively addresses the limitations of traditional methods, making in-home sleep scoring systems more viable for clinical use.
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We present a new approach to classifying the sleep stage that incorporates a computationally inexpensive method based on permutations for channel selection and takes advantage of deep learning power, specifically the gated recurrent unit (GRU) model, along with other deep learning methods. By systematically permuting the electroencephalographic (EEG) channels, different combinations of EEG channels are evaluated to identify the most informative subset for the classification of the 5-class sleep stage. For analysis, we used an EEG dataset that was collected at the International Institute for Integrative Sleep Medicine (WPI-IIIS) at the University of Tsukuba in Japan.

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Background: Although the association between higher physical activity and preventive effect on breast-cancer-related lymphoedema (BCRL) has been reported, it is unclear what intervention is optimal. We aimed to investigate the effect of exercise and educational programs on BCRL development.

Methods: This study was a secondary endpoint analysis from a prospective randomized controlled trial.

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  • - 17q12 deletion syndrome is a rare genetic condition caused by a specific deletion on chromosome 17, leading to varied health issues in individuals.
  • - A 35-year-old Japanese man was studied, revealing a 1.46 Mb deletion causing multiple health problems, including maturity-onset diabetes, kidney and liver issues, and facial dysmorphic characteristics.
  • - This case adds to our understanding of the diverse symptoms associated with 17q12 deletion syndrome, highlighting its clinical implications.
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We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection.

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We present a case of recurrent ovarian cancer at the age of 75, gravida 1 para 0, with 18 years of disease-free survival. Chemotherapy brought a 10-month partial response status; to further improve the overall survival, the patient was evaluated using the AGO score (DESKTOP III trial, 2020), which was originally intended for cases immediately after the diagnosis of recurrence; the score has indicated a significant outcome; the patient went through a hepatosplenic metastatic site resection; and complete resection was achieved. Subsequently, the PARP inhibitor was introduced, which has led to 14 months of disease-free survival.

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  • - The study evaluated a gamification program that uses non-monetary points to encourage exercise among cardiovascular disease patients, analyzing its impact on daily step counts over a 4-week period.
  • - A total of 29 CVD patients participated, with significant increases in average daily step counts observed during intervention weeks (ranging from 1,165 to 1,508 steps).
  • - Results indicated that women were more likely to achieve step goals, while higher body mass index correlated with smaller increases in step counts, demonstrating the program’s potential effectiveness for promoting physical activity in this patient group.
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In acute lung injury (ALI), a severe insult induces a hyperinflammatory state in the lungs. The mortality rate of severe ALI remains high, and novel mechanistic insights are required to improve therapeutic strategies. Endothelin-2 (Edn2), the least studied isoform of endothelin, is involved in lung physiology and development and can be affected by various factors.

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Background: It is unclear what interventions can sustain long-term higher physical activity (PA) to improve breast cancer outcomes. Thus, this study aimed to evaluate the long-term effects of interventions on PA after breast cancer treatment.

Methods: This was a prospective randomized controlled trial for patients with stage 0 to III breast cancer evaluating the efficacy of exercise and educational programs on long-term PA compared with usual care.

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Purpose: Tamoxifen is used for the suppression of estrogen-sensitive tumor recurrence in oocyte retrieval cycles. This meta-analysis aimed to evaluate the quality of controlled ovarian stimulation (COS) with co-administration of gonadotropins and tamoxifen (COS with tamoxifen).

Methods: PubMed, Embase, and Cochrane Library were searched for articles on October 30, 2022.

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Purpose: Emojis are commonly used for daily communication and may be useful in assessing patient-reported outcomes (PROs) in breast cancer. The purpose of this study is to develop and validate a Symptom Illustration Scale (SIS) as a new PRO measurement.

Methods: Eighteen original SIS items were developed from the PRO-CTCAE.

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  • Pulmonary arterial hypertension (PAH) is a serious disease marked by increased pressure in the pulmonary arteries caused by changes in the structure of these blood vessels.
  • Research shows that aging in endothelial cells (ECs) negatively impacts PAH by affecting nearby smooth muscle cells (SMCs) through a process called juxtacrine interaction.
  • Inhibiting Notch signaling, which is activated by senescent ECs, can mitigate the effects on SMCs and improve PAH symptoms, highlighting a potential treatment strategy, especially for older patients.
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We report an experimental setup for simultaneously measuring specific heat and thermal conductivity in feedback-controlled pulsed magnetic fields of 50 ms duration at cryogenic temperatures. A stabilized magnetic field pulse obtained by the feedback control, which dramatically improves the thermal stability of the setup and sample, is used in combination with the flash method to obtain absolute values of thermal properties up to 37.2 T in the 22-16 K temperature range.

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  • - *The study aimed to assess the safety of stopping methotrexate (MTX) after achieving remission in rheumatoid arthritis (RA) patients treated with a combination of tocilizumab (TCZ) and MTX.* - *Patients were divided into two groups: one that discontinued MTX after remission (DISC group) and another that continued MTX (MAIN group); results showed better disease activity scores and higher remission rates in the DISC group.* - *The findings suggest that it is feasible to discontinue MTX in patients who have responded well to TCZ+MTX therapy, even if they have a longer disease duration and more advanced RA stage.*
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Pulse rate variability (PRV), derived from Laser Doppler flowmetry (LDF) or photoplethysmography, has recently become widely used for sleep state assessment, although it cannot identify all the sleep stages. Peripheral blood flow (BF), also estimated by LDF, may be modulated by sleep stages; however, few studies have explored its potential for assessing sleep state. Thus, we aimed to investigate whether peripheral BF could provide information about sleep stages, and thus improve sleep state assessment.

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Study Objective: Traditionally, age-related deterioration of sleep architecture in older individuals has been evaluated by visual scoring of polysomnographic (PSG) recordings with regard to total sleep time and latencies. In the present study, we additionally compared the non-REM sleep (NREM) stage and delta, theta, alpha, and sigma wave stability between young and older subjects to extract features that may explain age-related changes in sleep.

Methods: Polysomnographic recordings were performed in 11 healthy older (72.

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Pharmaceutical plants contain several phytochemicals that are sources of myriad biological activities. These biological activities can be explored in multiple fields for the benefit of mankind. Pharmaceutical plants with high ethnobotanical indices (i.

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Scoring sleep stages from biological signals is an essential but labor-intensive inspection for sleep diagnosis. The existing automated scoring methods have achieved high accuracy but are not widely applied in clinical practice. In our understanding, the existing methods have failed to establish the trust of sleep experts (e.

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Lung cancer is the leading cause of cancer-related deaths worldwide, and adenocarcinoma is the most common subtype of lung cancer. Endothelin-2 (ET-2) is expressed in the epithelium of alveoli, and its expression is increased in cancer. However, the role of ET-2 in lung adenocarcinoma remains unclear.

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  • - The study analyzed data from the ORIGAMI trial to determine if adding methotrexate (MTX) affects the outcomes of abatacept treatment in patients with rheumatoid arthritis who hadn't used biologics before.
  • - A total of 325 patients were split into two groups: those who received abatacept alone (MTX-) and those who received it with MTX (MTX+), and various health indicators were assessed over 52 weeks.
  • - Results showed no significant differences in disease activity or retention rates of abatacept between the two groups after a year, suggesting that using MTX alongside abatacept might not provide extra benefits.
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  • A study explored the use of rosemary (Rosmarinus officinalis) as a natural herbicide due to its plant growth-inhibitory effects, specifically through the compound carnosic acid.
  • Researchers analyzed how seasonal variations affect carnosic acid levels and phytotoxicity in rosemary leaves collected from two locations in Tunisia during 2011-2012.
  • Results indicated that rosemary leaves had the highest carnosic acid concentration and growth inhibition effects during summer, suggesting that environmental factors like temperature and elevation play a significant role in these variations.
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Trastuzumab-emtansine (T-DM1) is a therapeutic agent molecularly targeting human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC), and it is especially effective for MBC with resistance to trastuzumab. Although several reports have described T-DM1 resistance, few have examined the mechanism underlying T-DM1 resistance after the development of acquired resistance to trastuzumab. We previously reported that YES1, a member of the Src family, plays an important role in acquired resistance to trastuzumab in -amplified breast cancer cells.

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