Publications by authors named "Yoko Susami"
Article Synopsis
- CCR4 is identified as an important receptor for T-helper 2 (Th2) and Th17 cells and is a potential target for treating atopic dermatitis (AD).
- In a mouse model of AD induced by MC903 (a TSLP inducer), increased levels of Th2 and Th17-related cytokines and immune cell infiltration were observed, leading to skin lesions.
- Using a CCR4 inhibitor, Compound 22, showed promise in reducing Th2 and Th17 cells and improving AD-like symptoms, suggesting CCR4 antagonists could help manage allergic reactions in AD.
Atopic dermatitis (AD) is the most common inflammatory skin disease, which is characterized by excessive Th2 immune responses. In AD patients, the expression of the chemokines CCL17 and CCL22 is increased in skin lesions, leading to the infiltration of Th2 cells. In addition, typical pro-inflammatory cytokines, including TNF-α, IL-1β and IL-6, have also been shown to be associated with the pathogenesis of AD.
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