Publications by authors named "Yoko Kuriyama"
Iron is an essential trace metal, vital for various physiologic processes, but excess levels can harm health. Maintaining iron homeostasis is critical, with hepcidin playing a key role. The isoform hepcidin-25 exerts the most significant influence on iron metabolism, making its serum levels a valuable diagnostic tool.
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- Recent findings indicate that the BRAF V600E mutation is targetable in colorectal neuroendocrine cancers, with a combination therapy involving a BRAF inhibitor and anti-EGFR antibody recommended for patients with this mutation.
- A case study of a 77-year-old man with lymph node recurrence of ascending colonic NEC revealed that after unsuccessful traditional chemotherapy, treatment was switched to the targeted regimen, leading to significantly reduced tumor markers and notable shrinkage of metastases.
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- This study examines the link between BRCA1/BRCA2 variants and the risk of ovarian cancer (OC) in families with these genetic mutations in Japan.
- It found that family members with the Q934X variant have a significantly higher ratio of OC to breast cancer (BC) compared to those with other BRCA1 variants, suggesting increased OC risk associated with this variant.
- Additionally, the R2318X variant showed a higher OC to BC ratio than the overall BRCA2 value, highlighting the potential for certain BRCA variants to impact cancer risk differently.
We present a case of a patient whose L1CAM gene in X-chromosome has a C924T transition. Her first son's ventriculomegaly was prenatally detected. A mature infant was born, his head circumference was large, and thumbs were bilaterally adducted.
View Article and Find Full Text PDFThe present research investigated whether children's referential choices for verb arguments are motivated by pragmatic features of discourse referents across different developmental stages, not only for children learning null argument languages but also for those learning overt argument languages. In Study 1, the form (null, pronominal, or lexical) and referential status (given or new) of verb arguments were systematically analysed in six English-speaking and six Japanese-speaking children and their mothers when the children were at 1;9 and 3;0. In Study 2, non-linguistic pragmatic correlates (pointing, reaching, moving, making a head motion, or purposeful gaze direction toward a referent) were analysed in addition to the form and referential status of arguments at each of four linguistic periods between MLU 1 00 and 4 00 in two English-speaking and two Japanese-speaking children and their mothers.
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