Enhancing circularly polarised luminescence by extending the π-conjugation of axially chiral compounds.

Circularly polarised luminescence (CPL) and photoluminescence (PL) properties of π-conjugated (R)- and (S)-2,2'-diphenyl-4-biphenanthrol (VAPOL) exhibited an efficient CPL (∼1.3 × 10(-3)) with a quantum yield (ΦF) of 0.20 at 376 nm.

Rhythmic post-transcriptional regulation of the circadian clock protein mPER2 in mammalian cells: a real-time analysis.

Post-transcriptional/translational mechanisms regulate the circadian clock system of many organisms, including mammals. The level of the essential clock protein mPER2 daily oscillates in peripheral cells as well as in neurons of the master oscillator in the suprachiasmatic nucleus (SCN). Post-translational modifications of mPER2, such as phosphorylation and ubiquitination, are likely involved in the regulation of its stability and intracellular accumulation rhythms, which in turn create an approximately 2-4 h delay from the rhythm of mPer2 mRNA.