Publications by authors named "Yoko Ayukawa"
Article Synopsis
- GWAS studies primarily in European and Hispanic populations have identified genetic factors linked to childhood acute lymphoblastic leukemia (ALL), but findings are not as clear for other racial and ethnic groups.
- DNA samples from Japanese ALL patients were analyzed, showcasing associations with genetic regions linked to the disease, including notable findings for ARID5B and PIP4K2A, with varying levels of risk.
- The study highlights significant differences in genetic linkage patterns between Japanese and European populations, marking an important step in understanding genetic susceptibility to childhood ALL in Japan.
Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a highly significant role in neurodegenerative diseases, CNS trauma, as well as psychiatric disease and have become a target for small molecule and biologic therapies. We report the development of a method for measuring pharmacodynamic changes induced by potential CNS therapeutics using nasal olfactory neural tissue biopsy.
View Article and Find Full Text PDFGlutamate is the predominant excitatory amino acid neurotransmitter in the mammalian central nervous system (CNS). Glutamate transporter EAAT2/GLT-1 is the physiologically dominant astroglial protein that inactivates synaptic glutamate. Previous studies have shown that EAAT2 dysfunction leads to excessive extracellular glutamate and may contribute to various neurological disorders including amyotrophic lateral sclerosis (ALS).
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