Publications by authors named "Yoji Hisamatsu"

Article Synopsis
  • Immuno-oncology (IO) drugs are critical for cancer treatment, but older patients face safety issues, including higher hospitalization rates despite similar rates of immune-related adverse events (irAEs) compared to younger groups.* -
  • A study analyzing clinical data from 181 patients over 80 years old found that 35% experienced irAEs, with 19% discontinuing therapy; elevated eosinophil counts were identified as a significant risk factor for developing these events.* -
  • Overall, IO therapy is deemed safe for older patients, but those starting treatment with high eosinophil counts require careful monitoring.*
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Introduction: OHVIRA syndrome is a rare congenital anomaly of Müllerian duct development characterized by uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. The primary treatment is surgical excision of the obstructed hemivaginal septum and hematometrial drainage. In recent years, minimally invasive approaches such as hysteroscopic or vaginoscopic septum resection have been reported.

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Objective: This study evaluated the feasibility and outcomes of pneumovaginoscopy-assisted radical hysterectomy (PVRH) for cervical cancer up to stage IIA using a bidirectional fascia-oriented and nerve-sparing surgical approach.

Methods: This retrospective observational cohort study examined the operative outcomes and prognoses of patients who underwent PVRH (n=59) for up to stage IIA cervical cancer. The basic procedure was Kyoto B2 (Viper Type II nerve-sparing) radical hysterectomy and pelvic lymphadenectomy through simultaneous vaginal and abdominal (open or laparoscopic) approaches.

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The pilot study was performed to assess the usefulness of a newly developed patientand physician-friendly intravaginal irradiation system for photodynamic therapy with 5-aminolevulinic acid (5-ALA PDT) for cervical intraepithelial neoplasia (CIN). We used an intravaginal balloon applicator to make the cervix upright and to adjust the position and direction of the laser source in the vagina, resulting in minimal patient discomfort and minimal effort required by the physician during irradiation. Ten outpatients of CIN2 or 3 with high-risk human papillomavirus (HPV) infection without a history of HPV vaccination were treated by 5-ALA PDT.

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Vaginoscopy has been mainly used diagnostically due to the lack of adequate equipment for performing complicated surgeries (Johary et al., 2015). However, herein, we report therapeutic vaginal endoscopic surgery (pneumovaginoscopy) for secondary malignant vaginal tumors using the vNOTES technique and devices (Kita et al.

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Article Synopsis
  • - Preeclampsia is a serious pregnancy condition marked by high blood pressure and protein in urine, affecting both mothers and fetuses, but its mechanisms are not fully understood.
  • - This study investigated early-onset (before 34 weeks) and late-onset (34 weeks or later) preeclampsia, analyzing placental immune-related gene expression and focusing on CD200 levels.
  • - Findings showed that CD200 was significantly upregulated in early-onset preeclampsia, suggesting different underlying mechanisms for early and late onset, though it's unclear if CD200's increase is a cause or an effect of the condition, indicating the need for more research.
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Vaginal stump recurrence post-hysterectomy for gynecologic malignancies occurs in 2%-3% of cases. Local excision has been recognized as the primary treatment of localized recurrence, in which precise surgical margin is critical. However, R0 resection is not always easy, given the deep and narrow operation field, as well as severe postoperative fibrosis or adhesion of the vaginal stump at times.

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Article Synopsis
  • The study examines the expression and role of NDRG1 in the human ovary, which is linked to cellular processes like growth and oxygen sensing but is not well understood in this context.
  • Follicular fluid and luteinized granulosa cells were analyzed for NDRG1 levels, revealing a positive correlation between NDRG1 and other important factors like VEGF and progesterone during stress conditions induced by cobalt chloride.
  • Findings suggest that NDRG1 is crucial for follicular development and early luteinization, with its expression being influenced by hypoxic conditions and modulated by treatments like echinomycin.
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Cyclic changes, such as growth, decidualization, shedding, and regeneration, in the human endometrium are regulated by the reciprocal action of female hormones, such as estradiol (E), and progesterone (P). Matrix metalloproteases (MMPs) and tissue inhibitors of MMPs (TIMPs) control the invasion of extravillous trophoblast cells after implantation. Several MMPs and TIMPs function in the decidua and endometrial stromal cells (ESCs).

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Uterine natural killer cells are regulated via surface inhibitory receptors for IL15 and galectin-9 (LGALS9) secreted by endometrial stromal cells (ESCs). However, the mechanism that regulates LGALS9 mRNA levels in ESCs is unclear. The aim of this study is to clarify the transcriptional regulation of LGALS9 in ESCs.

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Vaginal surgery is a classic and unique gynecologic procedure. However, the operation field is narrow, which may make surgery difficult to perform. While vaginoscopy or vaginal endoscopy could be the solution of choice, they are mainly used for diagnosis due to the lack of adequate equipment to perform complicated surgery (Johary et al.

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Article Synopsis
  • The study investigates how cigarette smoke affects the maturation of the endometrium, which is crucial for reproductive health, by looking at its impact on human endometrial stromal cells (ESCs).
  • Researchers cultured ESCs with different concentrations of cigarette smoke extract (CSE) and hormones to assess changes in cell behavior and specific gene expressions.
  • Results indicate that higher concentrations of CSE hinder cell growth and induce cell death, while lower concentrations affect the expression of factors related to blood vessel formation and hormonal signaling, ultimately suggesting that smoking negatively impacts endometrial development.
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Aim: The study aimed to elucidate the glycolytic metabolism of human endometrial stromal cells (hESCs) in hypoxic environment.

Main Methods: The hESCs were cultured in hypoxic environment, and their metabolic pathways were analyzed using metabolomics. We assessed glucose uptake using 2-deoxyglucose (2-DG) assay.

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Cyclic changes of the human endometrium, such as proliferation, secretion, and decidualization, occur during regular menstrual cycles. Heart- and neural crest derivatives-expressed transcript 2 (HAND2) is a key transcription factor in progestin-induced decidualization of human endometrial stromal cells (ESCs). It has been suggested that HAND2 regulates interleukin 15 (IL15), a key immune factor required for the activation and survival of uterine natural killer (uNK) cells.

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Purpose: Resveratrol is a well-known potent activator of sirtuin-1 (SIRT1). We investigated the direct effects of hypoxia and resveratrol on SIRT1/ peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) pathways, vascular endothelial growth factor (VEGF), hypoxia-inducible factor (HIF)-1α, and mitochondrial quantity in a steroidogenic human ovarian granulosa-like tumor cell line (KGN) cells.

Methods: KGN cells were cultured with cobalt chloride (CoCl; a hypoxia-mimicking agent) and/or resveratrol.

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Heart and neural crest derivatives-expressed transcript 2 (HAND2) is a key transcription factor in progestin-induced decidualization of human endometrial stromal cells (ESCs). In the mouse, HAND2 plays an important role in uterine receptivity by suppressing several fibroblast growth factors (FGFs). However, the regulation of FGF family members by progestin-induced HAND2 and the role of FGF in vascular regeneration in the endometrium remains poorly understood.

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