Publications by authors named "Yoichiro Kubo"
Article Synopsis
- Multichannel functional near-infrared spectroscopy (fNIRS) measures changes in cerebral blood flow, showing that depression is linked to decreased blood flow in the frontal cortex, known as hypofrontality.
- Repetitive transcranial magnetic stimulation (rTMS) and electroconvulsive therapy (ECT) are alternative treatments for depression, although their mechanisms are not fully understood.
- This study found that after 30 rTMS sessions, patients experienced a significant increase in oxygenated hemoglobin, indicating improved blood flow in the frontal cortex, which may activate neuronal synapses and enhance treatment effects.
Clozapine is the only effective antipsychotic drug used for the treatment of treatment-resistant schizophrenia. Although it has been shown that the frequency of clozapine use is very low in Japan, our previous study revealed that the number of clozapine prescriptions has been increasing in recent years, and that risk factors leading to discontinuation of clozapine were also identified as age ≥40 years, poor tolerability to olanzapine, previous treatment with clozapine, and white blood cell count <6000/mm. The main cause for discontinuation of clozapine is the occurrence of a wide range of adverse events, including neutropenia/leukopenia and fatal cardiac disorders.
View Article and Find Full Text PDFObjective: The prevalence of attention deficit/hyperactivity disorder (ADHD) in school-age children is 7.2%, and ADHD is divided into clinical subtypes.
Methods: The current study explored whether specific cognitive profiles as assessed using the Wechsler Intelligence Scale for Children (WISC)-IV could be obtained for each clinical ADHD subtype (ADHD-Inattentive type and ADHD-Combined type) and investigated the correlation between WISC scores and parental age at their children's birth or birthweight.