Publications by authors named "Yohei Sato"

Article Synopsis
  • Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition affecting the nasal passages, and this study aims to analyze specific memory B-cells (BRM) in this context.
  • Researchers found that while BRM cells exist in normal sinonasal tissue, their presence is much more pronounced in nasal polyps from CRSwNP patients, as shown through advanced laboratory techniques.
  • This discovery could enhance understanding of immune responses in CRSwNP and pave the way for new treatments, including therapies targeting B-cells.
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The anisotropic electronic structure of MgB2C2 was studied using soft X-ray emission spectroscopy electron microscopes. MgB2C2 fragments were selected by examining C K-emission profiles. C and B K-emission and Mg L-emission spectra were obtained, revealing common and distinct structures that reflect the mixing of valence orbitals.

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Article Synopsis
  • Thromboembolism is a critical concern in patients undergoing endovascular treatment for ruptured cerebral aneurysms, and administering antiplatelet agents like aspirin before the procedure may lower this risk.
  • The study, called ASTOP, is a multicenter, randomized, double-blind trial involving 484 patients, comparing the effects of 200 mg of aspirin versus a placebo prior to treatment.
  • Primary outcomes will focus on measuring thromboembolic complications and ischemic lesions during the procedure, while secondary outcomes will assess cerebral ischemic events, bleeding incidents, and patient functional status after 90 days.
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Plasmacytoid dendritic cells (pDCs) are a distinct subset of DCs involved in immune regulation and antiviral immune responses. Recent studies have elucidated the metabolic profile of pDCs and reported that perturbations in amino acid metabolism can modulate their immune functions. Glycolipid metabolism is suggested to be highly active in pDCs; however, its significance remains unclear.

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Article Synopsis
  • The study examines clinical outcomes of two treatment options for distal anterior cerebral artery (DACA) aneurysms: microsurgery and endovascular treatment (EVT).
  • It analyzes data from 166 patients across 16 stroke centers, comparing the efficacy, complications, and recurrence rates of both treatments over a median follow-up of 15.3 months.
  • Findings suggest that while EVT may be a viable alternative to microsurgery, especially for unruptured aneurysms, it shows higher recurrence and retreatment rates, particularly in cases of ruptured aneurysms, highlighting the need for careful monitoring.
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Background And Objectives: Although intraprocedural rupture (IPR) is rare, it is a devastating complication of endovascular treatment (EVT) for intracranial aneurysms. Very few studies have been conducted on IPR, and the safety and efficacy of management techniques of IPR have not been investigated.

Methods: Patients who experienced IPR during EVT between 2013 and 2022 were enrolled from a multicenter observational registry.

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Subarachnoid hemorrhage due to the A1 segment of an anterior cerebral artery dissecting aneurysm is rare. Therefore, a standard treatment has not been established. Though several case reports of direct surgery exist, there are few reports on endovascular treatment.

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Article Synopsis
  • This study investigates the effectiveness of first-line contact aspiration compared to other treatment strategies for basilar artery occlusion in endovascular thrombectomy.
  • A total of 84 patients from 16 Japanese stroke centers were analyzed, with findings showing no significant differences in recanalization rates but indicating contact aspiration led to faster results.
  • The results suggest that while contact aspiration gives better functional outcomes, the main advantage is a significantly shorter time from puncture to successful recanalization.
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The structural characterization of epoxy resins is essential to improve the understanding on their structure-property relationship for promising high-performance applications. Among all analytical techniques, scanning transmission electron microscopy-electron energy-loss spectroscopy (STEM-EELS) is a powerful tool for probing the chemical and structural information of various materials at a high spatial resolution. However, for sensitive materials, such as epoxy resins, the structural damage induced by electron-beam irradiation limits the spatial resolution in the STEM-EELS analysis.

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The mechanisms underlying the influence of the surface chemistry of inorganic materials on polymer structures and fracture behaviours near adhesive interfaces are not fully understood. This study demonstrates the first clear and direct evidence that molecular surface segregation and cross-linking of epoxy resin are driven by intermolecular forces at the inorganic surfaces alone, which can be linked directly to adhesive failure mechanisms. We prepare adhesive interfaces between epoxy resin and silicon substrates with varying surface chemistries (OH and H terminations) with a smoothness below 1 nm, which have different adhesive strengths by ~13 %.

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This study proposes a simple evaluation method for deriving L-absorption information from two L-emission spectra of 3d transition metal (TM) elements obtained at two different accelerating voltages. This method realizes a spatial identity for X-ray emission and absorption spectroscopies. This method was evaluated for the Fe L-emission spectra of Fe and its oxides and was applied to the TM L-emission spectra of MnO, Co, CoO and NiO.

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Although various benefits of human milk oligosaccharides (HMOs) have been reported, such as promoting growth in the infant gut, their effects on adults have not been fully studied. This study investigated the effects of two types of sialyllactose, 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL), on the adult intestinal microbiome using the simulator of human intestinal microbial ecosystem (SHIME), which can simulate human gastrointestinal conditions. HPLC metabolite analysis showed that sialyllactose (SL) supplementation increased the short-chain fatty acid content of SHIME culture broth.

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Aim: Assessing the indication for elective neuro-endovascular treatment (EVT) in older patients requires consideration of the impact of systemic comorbidities on their overall reduced life expectancy. The objective of this study was to determine the long-term outcomes of elective neuro-EVT in patients aged ≥80 years, and to investigate the impact of pre-existing cancer on their long-term outcomes.

Methods: Of the patients enrolled in multicenter observational registry, those aged ≥80 years undergoing elective neuro-EVT between 2011 and 2020 were enrolled.

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Regulatory T cells (Tregs) play a central role in modulating adaptive immune responses in humans and mice. The precise biological role of non-canonical nuclear factor 'κ-light-chain-enhancer' of activated B cells (NFKB) signaling in human Tregs has yet to be fully elucidated. To gain insight into this process, a Treg-like cell line (MT-2) was genetically modified using CRISPR/Cas9.

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Article Synopsis
  • FOXP3 is a key transcription factor for regulatory T cell (Treg) function, and defects in Tregs can lead to autoimmune diseases like IPEX due to genetic mutations.
  • A phase I clinical trial has been initiated for IPEX patients using engineered Treg-like cells to improve treatment outcomes and reduce the need for immunosuppressive drugs.
  • A new humanized-mouse model (hu-mouse) was developed using CRISPR to knock out FOXP3, mimicking IPEX symptoms, and showed that injection of CD4 cells could restore Treg functions and control disease symptoms, making it a valuable tool for pre-clinical studies.
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We conducted a study to assess the pressure difference between the aqueous and vitreous humors in rabbit eyes using a direct intraocular pressure (IOP) measurement method. A micro-optic-fiber pressure sensor was utilized for this purpose. Preliminary experiments with enucleated porcine eyes confirmed the sensor's accuracy in measuring both aqueous and vitreous humor pressure.

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The structural evolution of highly mesoporous templated carbons is examined from temperatures of 1173 to 2873 K to elucidate the optimal conditions for facilitating graphene-zipping reactions whilst minimizing graphene stacking processes. Mesoporous carbons comprising a few-layer graphene wall display excellent thermal stability up to 2073 K coupled with a nanoporous structure and three-dimensional framework. Nevertheless, advanced temperature-programmed desorption (TPD), X-ray diffraction, and Raman spectroscopy show graphene-zipping reactions occur at temperatures between 1173 and 1873 K.

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Objective: We report a case in which transient cerebral vasospasm after carotid artery stenting (CAS) was effectively treated using arterial and intravenous infusion of fasudil hydrochloride, but cerebral hyperperfusion syndrome (CHS) developed during subsequent treatment.

Case Presentation: The patient was a 79-year-old man who underwent right CAS to treat symptomatic right carotid artery stenosis. After the procedure, the patient developed left paresis and unilateral spatial neglect.

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Article Synopsis
  • The study aimed to explore how baseline infarct area and collateral status affect clinical outcomes in stroke patients with acute basilar artery occlusion after undergoing endovascular treatment.
  • It analyzed 86 patients treated within 24 hours, finding that those with a higher baseline infarct score (pc-ASPECTS ≥ 7) had better chances of recovery, with 43% achieving good outcomes.
  • It concluded that while pc-ASPECTS is a reliable predictor of positive clinical outcomes after treatment, the collateral status scores did not show a significant impact.
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Purpose: The purpose of this study is to investigate the effects of denture adhesives on masticatory performance via a 10-center, parallel, randomized, controlled trial of complete denture wearers in Japan.

Methods: The trial was conducted between September 2013 and October 2016. The inclusion criteria were complete edentulism, willingness to undergo new complete denture treatment, and willingness to return for recall treatment.

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Article Synopsis
  • The study investigated the impact of different types of denture adhesives on retention and occlusal force in edentulous patients using a controlled trial design.
  • Two hundred patients were divided into three groups: those using powder-type adhesive, cream-type adhesive, and a control group with saline, and these were tested over a 4-day period.
  • Results showed that cream-type adhesives significantly enhanced denture retention and occlusal force, especially for patients with a moderate level of treatment difficulty, while powder-type adhesives did not show similar improvements.
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Gestures and speech, as linked communicative expressions, form an integrated system. Previous functional magnetic resonance imaging studies have suggested that neural networks for gesture and spoken word production share similar brain regions consisting of fronto-temporo-parietal brain regions. However, information flow within the neural network may dynamically change during the planning of two communicative expressions and also differ between them.

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Article Synopsis
  • The study aimed to determine how the location of brain infarcts, measured by the posterior circulation Alberta Stroke Program Early Computed Tomographic Score (pc-ASPECTS), affects patient outcomes after endovascular therapy for basilar artery occlusion.
  • Among 100 participants, 51% achieved favorable outcomes, with younger age, lower pre-treatment stroke severity, and higher pc-ASPECTS scores linked to better recovery.
  • The research concluded that higher pc-ASPECTS scores are predictive of better outcomes, while bilateral cerebellar infarction is associated with poorer recovery chances.
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The mechanisms of electron irradiation damage to epoxy resin samples were evaluated using their electron diffraction patterns and electron energy-loss spectra. Their electron diffraction patterns consisted of three indistinct halo rings. The halo ring corresponding to an intermolecular distance of ∼6.

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