Publications by authors named "Yohei Nagai"
Background: Several cohort studies have reported that post-esophagectomy morbidities may worsen prognosis. Smoking cessation is an effective prophylactic measure for reducing post-esophagectomy morbidity; however, whether smoking cessation can contribute to the improvement of prognosis is unknown due to the absence of reliable databases covering the cessation period. This study aimed to elucidate whether sufficient preoperative smoking cessation can improve prognosis after esophageal cancer surgery by reducing post-esophagectomy morbidity.
View Article and Find Full Text PDFBackground: Clinical significance of red blood cell distribution (RDW) as a predictive marker for the incidence of postoperative morbidity after esophagectomy for esophageal cancer has not been established.
Methods: This study included 634 consecutive patients who underwent three-incisional esophagectomy with lymphadenectomy for esophageal cancer between April 2005 and November 2020. Correlation between pretreatment RDW and patient background, cancer background, and short-term outcome after esophagectomy were retrospectively investigated.
Article Synopsis
- Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have shown promise in treating esophageal cancer, highlighting the need for a deeper understanding of local immune responses in this disease.
- A study of 433 resected esophageal cancer cases found that high PD-1 expression on tumor-infiltrating lymphocytes (TILs) predicted worse survival outcomes, especially in patients who did not receive preoperative treatment.
- The research concludes that PD-1 expression can serve as a prognostic biomarker, with the combination of PD-1 and PD-L1 levels providing valuable insights for classifying patient prognoses.
Background: Fusobacterium nucleatum (F. nucleatum) is a gut microbe implicated in gastrointestinal tumorigenesis. Predicting the chemotherapeutic response is critical to developing personalised therapeutic strategies for oesophageal cancer patients.
View Article and Find Full Text PDFFamily 1: a 39-year-old woman and her sister were admitted to our hospital for fundic gland polyps (FGPs). Their mother died of gastric cancer with FGPs. We performed repeated biopsies at close intervals, suspecting gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS).
View Article and Find Full Text PDFPurpose: In recent years, the concept of oligometastasis, which represents limited metastatic disease, has gained much interest. This study focuses on the oligometastatic recurrence (OLR) of esophageal squamous cell carcinoma (ESCC) after esophagectomy.
Methods: From among 514 patients who underwent curative resection for ESCC at our hospital between April 2005 and December 2019, 97 patients with recurrence were enrolled in this study.
Background: The predictive significance of programmed death ligand 1 (PD-L1) for programmed death 1 (PD-1) inhibitors remains unclear in gastric cancer (GC) due to the dynamic alteration by treatments. We aimed to elucidate the effects of trastuzumab (Tmab) on PD-L1 expression in GC.
Methods: PD-L1 expression was evaluated by multicolour flow cytometry analysis after co-culturing GG cell lines and immune cells with Tmab.
Introduction: The present study assessed the utility of a dry box time trial during laparoscopic surgical training to improve laparoscopic surgical skills and surgical outcomes.
Methods: In a monthly time trial, surgeon trainees twice completed a set task that involved grasping a suture, aligning a needle with a needle holder, passing the suture, making three knots, and cutting the two tails of the suture. The mean suturing time was then analyzed.
Purpose: Accumulating evidence suggests that the inflammatory tumor microenvironment can potentiate tumor progression and metastasis. The C-reactive protein-to-albumin ratio (CAR) is a novel inflammation-based prognostic score. This study was performed to examine the associations of the preoperative CAR with clinical outcomes in patients with colorectal liver metastases (CRLM) after curative resection.
View Article and Find Full Text PDFPurpose: Advanced esophageal cancer often results in esophageal stenosis or tracheoesophageal fistula. Esophageal bypass surgery and esophageal stent insertion are palliative treatments for esophageal cancer. With improvements in metallic stents and the stent insertion technique, esophageal stent insertion appears to be performed more frequently than bypass surgery, worldwide.
View Article and Find Full Text PDFBackground: Liver fibrosis influences liver regeneration and surgical outcomes, and several noninvasive models based on laboratory data have been developed to predict liver fibrosis. This study was performed to determine whether the Fibrosis-4 (FIB-4) index, a noninvasive fibrosis marker, can predict the prognosis in patients with colorectal liver metastases (CRLM) undergoing hepatectomy.
Methods: This retrospective study involved 193 consecutive patients with CRLM who underwent hepatectomy.
Background: The usefulness of quantitating tumor lesion glycolysis (TLG) from F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) findings as a tool for determining the effect of neoadjuvant chemotherapy (NAC) in esophageal squamous cell carcinoma (ESCC) has not yet been established.
Methods: The cohort of this retrospective study comprised 46 patients who had undergone NAC and subsequent esophagectomy for locally advanced ESCC between January 2008 and December 2017. PET/CT was conducted before and after NAC to assess its therapeutic effect.
Background: Port site recurrence has been observed after a variety of oncologic resection procedures. However, few have reported port site recurrence of esophageal cancer.
Case Presentation: A 51-year-old man underwent minimally invasive esophagectomy for pT3(AD)N3M0 adenocarcinoma of the esophagus.
Background: IgG4-related disease (IgG4-RD) is an immune-mediated disorder in which abundant IgG4-positive plasma cells infiltrate affected organs. There have been reported four cases of probable IgG4-RD presenting as a submucosal tumor of the stomach. We herein report the first case of definite IgG4-RD presenting as a submucosal tumor of the stomach resected with laparoscopic endoscopic cooperative surgery (LECS).
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted on 504 male patients who underwent esophagectomy for cancer to examine how the type of person providing support affects patient outcomes, focusing on the role of a wife as a key support figure.* -
- Results showed that male patients with their wives as key support had significantly better overall survival rates compared to those without their wives, indicating their presence is a protective factor for recovery.* -
- However, having a wife did not influence nutritional status or survival after cancer recurrence, suggesting that while their support improves survival, it may not directly impact other postoperative health aspects.*
Background: The PD-1/PD-L1 pathway plays critical roles in tumour immunology, and serves as an immune-based therapeutic target. Less is known regarding PD-L2, another ligand of PD-1, and its relation to clinical outcome in human cancers.
Methods: We used a database of 437 surgically and 100 endoscopically resected oesophageal cancers (squamous cell carcinoma, n = 483; adenocarcinoma, n = 36; others, n = 18) to evaluate PD-L2 and PD-L1 expression by immunohistochemistry.
Article Synopsis
- * He underwent a laparoscopic surgery to remove the sigmoid colon cancer first to prevent potential complications during treatment of the NET.
- * The case suggests that surgery for the colorectal cancer should be prioritized before starting systemic therapy for GI-NETs if it could interfere with the treatment process.
Background: Serum anti-p53 antibody is used clinically as a tumor marker of colorectal cancer. However, its prognostic significance in patients with metastatic colorectal cancer (mCRC) remains unclear. KRAS status may influence the host immune response against tumor progression.
View Article and Find Full Text PDFLaparoscopic surgery for colorectal cancer with persistent descending mesocolon.
World J Surg Oncol
November 2019
Background: Persistent descending mesocolon (PDM) is caused by the absence of fusion of the descending colon to the retroperitoneum. We herein report two colorectal cancer cases with PDM that were treated with laparoscopic surgery.
Case Presentation: Case 1: a 50-year-old man with sigmoid colon cancer and synchronous liver metastasis.
Background: The incidence of metastatic spread of gastrointestinal malignancies to the thyroid gland is relatively low and most of these malignancies originate from the colorectum. Thyroid metastasis originating from the esophagus is poorly documented.
Case Presentation: A 79-year-old man presented with hoarseness of voice and swallowing difficulty.
Background: The tumor proportion score (TPS) and combined positive score (CPS) have been developed to assess programmed death ligand 1 (PD-L1) expression in gastric cancer (GC). This study aimed to elucidate the role of TPS and CPS as prognostic biomarkers.
Methods: A total of 191 patients with GC who received curative gastrectomy were retrospectively enrolled.
Article Synopsis
- * Out of 78 analyzed patients, 11.5% had LPLN metastasis, with factors like tumor location, preoperative imaging results, and distant metastasis identified as significant predictors.
- * The findings revealed that patients with LPLN metastasis had worse disease-free and cancer-specific survival rates, suggesting limited benefits of LPLN dissection in stage IV lower rectal cancer unless patients have specific symptoms.