Publications by authors named "Yohei Isomura"
Introduction: Heart involvement is a common problem in systemic sclerosis. Recently, a definition of systemic sclerosis primary heart involvement had been proposed. Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients.
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- Primary heart involvement in systemic sclerosis can lead to serious cardiac issues and is a significant cause of mortality, highlighting the need for a clear definition for research purposes.
- A systematic review and expert consensus using voting identified a definition for cardiac involvement in systemic sclerosis, achieving strong validity and reliability measures.
- The newly proposed definition is intended to guide future clinical research and improve understanding of heart-related complications in systemic sclerosis.
Objective: To investigate outcomes following the tapering or discontinuation of tocilizumab in patients with diffuse cutaneous SSc (dcSSc) in a real-world setting.
Methods: Fifteen patients who were treated with tocilizumab for dcSSc were selected from a single-centre cohort database and were evaluated for serial changes in the modified Rodnan total skin thickness score (mRSS) and predicted forced vital capacity (FVC) and the occurrence of clinical worsening events after the introduction of tocilizumab.
Results: Over 12 months of treatment with tocilizumab, the mRSS decreased from 20.