Efficacy and safety of low- and high-dose slow oral egg immunotherapy for hen's egg allergy: Single-center non-inferiority randomized trial.

Background: Low-dose oral immunotherapy (OIT) is a safe treatment for hen's egg allergy; however, comparison of its therapeutic effects with those of high-dose OIT has not been reported.

Objective: To compare the efficacy of low- and high-dose boiled egg-white (EW) OIT for hen's egg allergy.

Methods: Patients with hen's egg allergy were randomly assigned to two groups: OIT using hard-boiled EW with a maximum maintenance dose of 2 and 20 g in the low-dose (L-D) and high-dose (H-D) groups, respectively.

[LUNG FUNCTION IN EARLY-PERIOD SCHOOL-AGED ASTHMATIC CHILDREN MAY BE A PREDICTOR OF TREATMENT LEVEL AT ADOLESCENCE].

Background: Lung function in early-period school-aged children with asthma influences remission in adolescence. However, there are no reports of this in Japan.

Objective: This study investigated the influence of lung function in early-period school-aged asthmatic children on medication during adolescence.