Publications by authors named "Yohei Abe"

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  • Upstaging to pT3a after partial nephrectomy for cT1 renal cell carcinoma (RCC) is uncommon, occurring in 3.6% of cT1a and 19% of cT1b patients within a study of 389 cases from 2011-2022.
  • The median tumor size for upstaged cases was 43 mm, and during a 59-month follow-up, there were six recurrence events, highlighting a significant risk for those with Fuhrman grade ≥3.
  • Five-year survival rates were reported as 75.7% for metastasis-free survival, 96.2% for cancer-specific survival, and 88.1% overall, indicating
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  • The study aimed to assess the safety and effectiveness of neoadjuvant treatment with degarelix acetate and low-dose estramustine phosphate in men with high-/very high-risk prostate cancer before surgery.
  • A total of 187 patients participated, with 140 undergoing surgery after receiving 6 months of the treatment, highlighting adverse events, surgical outcomes, and rates of biochemical recurrence.
  • Results showed that patients with very high-risk status and those who reduced the dose of estramustine phosphate had lower rates of biochemical recurrence, indicating that maintaining dose compliance may impact survival outcomes in this group.
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  • The study aimed to evaluate the safety of preserving the urethra during radical cystectomy by using frozen section analysis (FSA) to check for recurrence of urothelial carcinoma.
  • Researchers analyzed 77 male patients who underwent FSA; those with abnormal results had their urethra removed, while those with normal results had it preserved.
  • The findings showed a 100% negative predictive value for FSA, and after an average follow-up of 38 months, no urethral recurrences were detected, highlighting the potential usefulness of FSA in guiding treatment decisions.
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  • - The study aimed to assess the effectiveness and safety of a chemotherapy regimen, dose-dense gemcitabine and cisplatin (ddGC), in treating muscle-invasive bladder cancer (MIBC) before surgery.
  • - Out of 45 patients treated, 92.7% completed the planned chemotherapy cycles, achieving a pathological complete response in 29.3% and an objective response in 41.5%.
  • - The results indicated that ddGC was well-tolerated, with severe adverse effects in only 17.8% of patients, and showed promising 2-year disease-free and overall survival rates of 70.8% and 89.2%, respectively.
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  • Bladder diverticula in older adults usually result from bladder outlet obstruction and are commonly treated alongside prostate issues using bladder diverticulectomy.
  • The reported study involved three patients who successfully underwent bladder diverticulectomy through a single cystotomy during robot-assisted laparoscopic radical prostatectomy, which minimizes complications and reduces surgery time.
  • The technique utilized a transvesical approach via the bladder neck for diverticula that are easily visible, making it a practical option compared to other methods that might require more invasive surgery.
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  • The study aimed to evaluate how the COVID-19 pandemic influenced the outcomes of robot-assisted radical prostatectomy (RARP) and urologists' treatment practices.
  • Researchers analyzed medical records of 208 patients who underwent RARP between 2017 and 2022, comparing data from pre-pandemic and pandemic periods, focusing on factors like preoperative hormone therapy, waiting times, and cancer pathology.
  • Results showed a significant increase in preoperative androgen deprivation therapy during the pandemic, shorter waiting periods for surgery, and a shift towards treating more high-risk patients, but no overall negative impact on cancer outcomes or patients' quality of life.
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  • - The study investigates the effects of enfortumab vedotin, a new treatment for urothelial cancer, focusing on how peripheral neuropathy impacts its effectiveness and if early nerve changes are linked to neuropathy onset.
  • - In a trial involving 34 patients with advanced bladder cancer who had not responded to previous therapies, the treatment showed promising results with a 52.9% overall response rate and significant survival benefits.
  • - Peripheral neuropathy was present in 12.5% of patients, but interestingly, those affected had better response rates compared to those without neuropathy; nerve studies showed that sensory nerves were more impacted, particularly the sural nerve.
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  • The study aimed to explore how frailty impacts cancer-related fatigue and quality of life in prostate cancer patients, analyzing 108 out of 254 outpatients.
  • Results showed a 63% prevalence of frailty, with older age linked to greater frailty severity but not to the levels of fatigue.
  • Patients with frailty experienced significantly higher fatigue and poorer quality of life compared to those without frailty, emphasizing the need to consider frailty in treatment decisions, especially for older patients.
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The nuclear receptor corepressor (NCoR) forms a complex with histone deacetylase 3 (HDAC3) that mediates repressive functions of unliganded nuclear receptors and other transcriptional repressors by deacetylation of histone substrates. Recent studies provide evidence that NCoR/HDAC3 complexes can also exert coactivator functions in brown adipocytes by deacetylating and activating PPARγ coactivator 1α (PGC1α) and that signaling via receptor activator of nuclear factor kappa-B (RANK) promotes the formation of a stable NCoR/HDAC3/PGC1β complex that coactivates nuclear factor kappa-B (NFκB)- and activator protein 1 (AP-1)-dependent genes required for osteoclast differentiation. Here, we demonstrate that activation of Toll-like receptor (TLR) 4, but not TLR3, the interleukin 4 (IL4) receptor nor the Type I interferon receptor, also promotes assembly of an NCoR/HDAC3/PGC1β coactivator complex.

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The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a component of the complex. Unexpectedly, we found that signaling by the receptor activator of nuclear factor κB (RANK) converts the NCoR/HDAC3 co-repressor complex to a co-activator of AP-1 and NF-κB target genes that are required for mouse osteoclast differentiation. Accordingly, the dominant function of NCoR/HDAC3 complexes in response to RANK signaling is to activate, rather than repress, gene expression.

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  • Noncoding genetic variation influences phenotypic differences in Kupffer cells, but the specific mechanisms and impacted cell types are not fully understood.
  • Research on inbred mouse strains revealed how environmental factors and leptin signaling affect Kupffer cell behavior, particularly in strains resistant to steatohepatitis.
  • The study shows that during regular conditions, genetic variation's broader (non-cell-autonomous) effects are prominent, while in response to acute stress, localized (cis-acting) genetic effects take precedence in controlling crucial transcription processes.
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  • The study aimed to evaluate how the shape of central tumours affects outcomes for patients undergoing robot-assisted partial nephrectomy (RAPN).
  • A total of 186 patients were analyzed, categorizing tumour shapes into four types and assessing their impact on achieving the defined "trifecta," which indicates successful surgical outcomes.
  • Results showed that tumours with complex-hump shapes had a significantly higher likelihood of failing the trifecta, highlighting the importance of preoperative morphology assessment in surgical planning.
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  • - A 40-year-old woman presented with vomiting and diarrhea, and imaging showed a cystic mass near her renal and iliac arteries, prompting a biopsy.
  • - Histopathology revealed spindle-shaped cell growth and positive markers for a perivascular epithelioid cell tumor; however, the final diagnosis was primary retroperitoneal lymphangioleiomyomatosis (LAM).
  • - Since the tumor was deemed unresectable and the patient had no poor prognostic lung lesions, she was monitored for 6 months, remaining asymptomatic with stable imaging results.
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Background: The efficacy of photodynamic diagnosis using 5-aminolevulinic acid during transurethral resection of bladder tumors has been demonstrated, albeit with limited information regarding its side effects. This study aimed to clarify the impact of oral 5-aminolevulinic acid on perioperative nausea and vomiting (NV) for the first time in a real-world clinical practice setting.

Methods: Patients who underwent transurethral surgery at Kagawa University between April 2017 and March 2020 were included.

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  • The study aimed to determine if placing prophylactic drains after laparoscopic nephroureterectomy for upper tract urothelial cancer is necessary.
  • It analyzed outcomes of 164 patients from 2011 to 2021, comparing those with (D+) and without (D-) drain placement.
  • Results showed no significant difference in complications between groups, but the D- group had a notably shorter hospital stay, indicating drains may not be needed.
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  • After 4 years of hormone treatment, his PSA levels improved significantly, leading to a decision for salvage robot-assisted prostate surgery due to non-metastatic castration-resistant prostate cancer.
  • Post-surgery, the patient's PSA dropped to undetectable levels, allowing him to stop hormone therapy, and he remained free of cancer recurrence for 3 years.
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Protein kinase A promotes beige adipogenesis downstream from β-adrenergic receptor signaling by phosphorylating proteins, including histone H3 lysine 9 (H3K9) demethylase JMJD1A. To ensure homeostasis, this process needs to be reversible however, this step is not well understood. We show that myosin phosphatase target subunit 1- protein phosphatase 1β (MYPT1-PP1β) phosphatase activity is inhibited via PKA-dependent phosphorylation, which increases phosphorylated JMJD1A and beige adipogenesis.

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  • The study compares robot-assisted (CRO-RAPN) and laparoscopic (CRO-LPN) techniques in partial nephrectomy for patients with localized renal masses from July 2012 to June 2020.! -
  • Results showed that CRO-RAPN had significantly better outcomes, including shorter operation and warm ischemic times, less blood loss, and lower complication rates compared to CRO-LPN.! -
  • Overall, CRO-RAPN also demonstrated a higher preservation rate of kidney function and a greater trifecta achievement rate, indicating its superiority in surgical performance and patient recovery.!
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A retrocaval ureter (RCU) is a rare cause of congenital ureteral obstruction that often requires surgical repair. We report two cases of RCU in adults treated with robot-assisted laparoscopic surgery. In both cases, we performed robotic ureteroureterostomy with dissection of the entire length of the retrocaval portion of the right ureter without complications.

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  • The study assessed the effects of continuing antithrombotic therapy during surgery on bleeding and complications in patients undergoing laparoscopic radical nephrectomy and nephroureterectomy.
  • It was conducted as a retrospective observational analysis, comparing outcomes between patients who continued their antithrombotic medications and those who did not, focusing on bleeding complications and other surgical markers.
  • The findings suggest that perioperative antithrombotic therapy does not significantly increase bleeding risk, indicating it is safe to continue during these surgical procedures.
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RAR-related orphan receptor-γ (RORγt) is an essential transcription factor for thymic T cell development, secondary lymphoid tissue organogenesis, and peripheral immune cell differentiation. Serine 182 phosphorylation is a major post-translational modification (PTM) on RORγt. However, the in vivo contribution of this PTM in health and disease settings is unclear.

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Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MSUc alone induce a metabolic-inflammatory transcriptional program in non-primed human and murine macrophages that is markedly distinct to that induced by LPS. Genes uniquely upregulated in response to MSUc belong to lipid and amino acid metabolism, glycolysis, and SLC transporters.

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Self-pierce riveting of three thin sheets of 980 MPa steel and 5052 aluminum alloy was performed to investigate the effect of sheet configuration on the deforming behaviors of the sheets and the rivet and joint strength. When the lower sheet was aluminum alloy, the joining range was relatively wide, i.e.

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  • A study aimed to compare the effectiveness of two diagnostic methods, 5-ALA-mediated photodynamic diagnosis (PDD) and narrow-band imaging (NBI), for detecting bladder cancer during transurethral resection of bladder tumors (TURBT).
  • In the study, 114 patients were given 5-ALA and their bladders were inspected using white light (WL), PDD, and NBI, with results compared to pathology outcomes.
  • The findings revealed that PDD had a higher sensitivity for detecting cancerous lesions than NBI (89.6% vs. 76.2%), suggesting that adding PDD to conventional methods can improve cancer detection rates significantly, especially for carcinoma in situ (CIS
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