Chemopreventive Activity of 80% Methanol Leaf Extract of Hiern (Asteraceae) Against Dimethylhydrazine-Induced Colorectal Carcinogenesis in Rats.

Background: Hiern (Asteraceae) is among Ethiopian herbal medicines that are traditionally used to treat skin and gastrointestinal cancers. In this study, the chemopreventive potential of leaf extract in dimethylhydrazine (DMH)-induced colorectal carcinogenesis in rats was investigated.

Methods: Rats were assigned to nine groups (normal, positive, and negative control groups, and three pre- and three post-initiation groups).

Evaluations of the laxative effects of aqueous root extracts of L. in mice.

Background: Management of constipation with currently available modern medicines is costly and chances of side effects are high. This limits their clinical usefulness and remain to be solved, and calls for investigations of new and better compounds. The experimental plant, L.

Wound Healing Activity of 80% Methanol Leaf Extract of (L.f) Sond (Cucurbitaceae) in Mice.

Background: is one of the folklore plants of Ethiopia frequently used for external wound treatment in humans. Nevertheless, pharmacological investigations have not been performed to substantiate activity of the plant extract in wound healing. Hence, this study attempted to explore the activity of leaf extract of in wound healing using a mice model.

Assessment of Prescription Pattern of Systemic Steroidal Drugs in the Outpatient Department of Menelik II Referral Hospital, Addis Ababa, Ethiopia, 2019.

Background: Because systemic corticosteroids are associated with severe adverse effects, a study on the prescribing pattern for rationalizing drug therapy is needed.

Objective: The purpose of this study was to assess the prescription pattern of systemic steroidal drugs at the outpatient department of Menelik II Referral Hospital, Addis Ababa, Ethiopia, 2019.

Methods: A cross-sectional study design was used to assess the prescription pattern of systemic steroidal drugs in the outpatient department of Menelik II Referral Hospital.

Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications.

Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of insulin resistance are released by adipose tissue. Besides, endoplasmic reticulum stress, adipose tissue hypoxia, oxidative stress, lipodystrophy, and genetic background have a role in insulin resistance.

A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment.

Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease-19 (COVID-19) that spreads quickly in the world. Considering the impact of this pandemic, researchers have been racing to understand the peculiar nature of the virus and the pathogenesis of the disease to uncover possible drug targets, effective therapeutic agents, and vaccines. Accordingly, numerous drug targets are identified by scientists.