Publications by authors named "Yoh T"
Background: This study aimed to evaluate the outcomes and role of lymphadenectomy in hypervascular intrahepatic cholangiocarcinoma (ICC) quantified using the arterial phase of contrast-enhanced computed tomography (CT).
Methods: Consecutive patients with mass-forming (MF) or predominantly MF type ICC who underwent surgical resection from 2000 to 2019 were retrospectively analyzed. Using the image of the late arterial phase, CT-vascularity was calculated by dividing the CT value of the tumor (Hounsfield units) with that of the liver parenchyma.
Background: Techniques involving dye injection or regional ischemia are commonly used for the precise identification of liver regions during hepatectomy. The visualization of regions with indocyanine green (ICG) has been widely used for liver segmentation. ICG is typically administered only once during each hepatectomy.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) tumor thrombus is generally considered to be borderline resectable because of its poor prognosis. This report describes a patient who underwent multidisciplinary treatment for HCC with massive IVC tumor thrombus.
Methods: The 56-year-old woman in this study had diffuse HCC of the medial and anterior segments.
A questionnaire survey was designed and performed to assess the current status of "next generation" hepatobiliary and pancreatic (HBP) surgeons regarding surgical training, career, recruiting, and work-life balance in Japan. Using a valid email address, a questionnaire was sent to members of the Japanese Society of Hepato-Biliary-Pancreatic Surgeons (JSHBPS) who were under 45 years old. The questionnaire comprised 50 questions across the following four sections: (i) board certification of JSHBPS, (ii) research activity and overseas study, (iii) recruiting, and (iv) work-life balance.
View Article and Find Full Text PDFArticle Synopsis
- A 60-year-old man had surgery for T2N0M0 gallbladder cancer, which showed high FDG uptake prior to the procedure.
- Two years after surgery, he developed multiple liver masses with lower FDG uptake, which were diagnosed as grade 3 neuroendocrine tumors through biopsy.
- The finding of neuroendocrine tumor components in the original gallbladder sample indicates that varying FDG uptake in cancers may require different diagnostic approaches.
Aim: Some patients undergoing liver resection for hepatocellular carcinoma (HCC) have poor outcomes. Therefore, we aimed to propose a new resectability classification for patients with HCC.
Methods: We classified patients into three categories: resectable (R), borderline resectable (BR), and unresectable (UR).
Optimizing terminology for pancreatectomy: Introducing a new notation system.
J Hepatobiliary Pancreat Sci
October 2024
We introduce a novel notation system for pancreatectomy designed to provide a clear and concise representation of surgical procedures. As surgical techniques and the scope of pancreatic surgeries continue to diversify, existing communication methods among medical professionals regarding the specifics of the surgeries have proven inadequate. Our proposed notation system clearly indicates the approach (open, laparoscopic, or robot-assisted), type of surgery (e.
View Article and Find Full Text PDFModification of the "new world" terminology: A new comprehensive notation for hepatectomy.
J Hepatobiliary Pancreat Sci
October 2024
Article Synopsis
- * A 51-year-old female patient developed a large hemorrhagic malignant perineurioma in her retroperitoneum, leading to critical complications like inferior vena cava obstruction, requiring extensive surgery.
- * Post-surgery, the patient underwent radiotherapy but unfortunately succumbed to disease progression, indicating the need for more effective treatment strategies and highlighting an NF2 mutation as a potential therapeutic target.
Background: Although laparoscopic-assisted donor hepatectomy (LADH) has become the definitive procedure for harvesting living donor livers, its surgical outcomes in association with donor body shape have not been elucidated.
Methods: The impact of donor factors, including thoracic shape, on LADH outcomes was retrospectively investigated. Thoracic anthropometric data were examined in all LADHs with a left/right graft between 2013 and 2022.
Article Synopsis
- This meta-analysis examined the effects of lymph node dissection (LND) during liver surgery for intrahepatic cholangiocarcinoma (ICC) by comparing outcomes between patients who underwent LND and those who did not.
- The analysis included 17 studies with a total of 4407 patients, finding no significant difference in overall survival (OS) between the two groups, but indicated better OS for LND in studies with low risk of bias.
- The results suggest routine LND may not broadly improve outcomes for all ICC patients, but certain factors, like being clinically node-negative, could make it beneficial for a specific subset of patients.
Background And Aim: Autotaxin (ATX) is an extracellular lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine into lysophosphatidic acid (LPA). Recent accumulating evidence indicates the biological roles of ATX in malignant tumors. However, the expression and clinical implications of ATX in human cholangiocarcinoma (CCA) remain elusive.
View Article and Find Full Text PDFBackgrounds: The success of direct-acting antiviral (DAA) therapy provides a cure for patients chronically infected with hepatitis C virus (HCV); however, outcomes after hepatectomy for HCV-associated hepatocellular carcinoma (HCC) before and after DAA introduction remain poorly studied.
Methods: Patients who underwent R0/R1 hepatectomy for HCV-associated HCC were retrospectively analyzed. Two time periods were defined: Pre-DAA (2007-2011, December 2013 was defined as the end of follow-up) and Post-DAA groups (2014-2018, December 2020 was defined as the end of follow-up).
Article Synopsis
- A recent trial showed that adjuvant S-1 chemotherapy significantly helps biliary tract cancer patients after surgery, but its real-world effectiveness when fully completed is unclear.
- Researchers reviewed data from 223 patients who had surgery for biliary tract cancer between 2011 and 2021, finding that 75 underwent chemotherapy and 64% completed it.
- Those who completed the chemotherapy had significantly better survival rates compared to those who didn’t, indicating that finishing the treatment is crucial for better outcomes.
The role of the ferroptosis-related gene glutathione peroxidase 4 (GPX4) in oncology has been extensively investigated. However, the clinical implications of GPX4 in patients with intrahepatic cholangiocarcinoma (ICC) remain unknown. This study aimed to evaluate the prognostic impact of GPX4 and its underlying molecular mechanisms in patients with ICC.
View Article and Find Full Text PDFPurpose: Our objective was to investigate the impact of albumin-bilirubin (ALBI) score at the time of post-hepatectomy hepatocellular carcinoma (HCC) recurrence on survival after recurrence (SAR). We further explored the perioperative factors associated with the ALBI score at recurrence.
Methods: Patients who underwent primary hepatectomy for HCC between 2007 and 2018 and developed recurrence were included in the study.
Pancreatic acinar cystic transformation (ACT) is a rare non-neoplastic cystic lesion that is predominantly located at the pancreatic head in females. Preoperative definitive diagnosis of ACT remains challenging despite advances in radiologic imaging methods. A 25-year-old male patient presented with abdominal discomfort and a 50-mm cystic lesion in the pancreatic tail.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed the long-term outcomes of patients with intermediate- and advanced-stage hepatocellular carcinoma who underwent liver resection, highlighting the significant recurrence rates of 94.7% and 90.7% for each stage, respectively.
- - Among 270 eligible patients evaluated, the 5-year survival rates were 49.7% for intermediate-stage and 36.8% for advanced-stage cancer, with 39.8% and 23.4% of patients receiving active salvage therapy after recurrence.
- - Findings indicate that while liver resection alone is often insufficient for achieving remission, active salvage therapies could extend survival, emphasizing the need for further research to reduce recurrence and enhance treatment efficacy.
Article Synopsis
- Recent advancements in simulation and navigation technologies have led to the development of patient-specific 3D-printed liver models for use in hepatobiliary surgeries to enhance surgical safety.
- In a clinical trial, surgeons used these models on 13 patients, finding that the models accurately represented original data with differences under 0.6 mm and helped identify critical structures, despite not impacting the operation time or blood loss.
- Post-operative feedback indicated that these 3D models improved safety and reduced psychological stress for surgeons, confirming their value as effective navigation tools for challenging liver procedures.*
Purpose: Prognostic value of liver volumetric regeneration (LVR) in patients with hepatocellular carcinoma (HCC) who undergo major hepatectomy remains unknown. The aim of this study was to investigate the impact of LVR on long-term outcomes in these patients.
Methods: Data of 399 consecutive patients with HCC who underwent major hepatectomy between 2000 to 2018 were retrieved from a prospectively maintained institutional database.
Background: Primary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphoma is very rare, so it is difficult to diagnose preoperatively. And there is no established treatment for hepatic MALT lymphoma. We report herein a case of primary hepatic MALT lymphoma treated by laparoscopic partial hepatectomy, and discuss the usefulness of laparoscopic hepatectomy for a rare liver tumor.
View Article and Find Full Text PDFNowadays, atezolizumab plus bevacizumab is recommended for advanced hepatocellular carcinoma (HCC) as the first-line systemic chemotherapy. Nevertheless, the data with regard to the tumor response still remain limited. We report a complete metabolic response assessed by 18 F-FDG PET/CT in a 74-year-old man with advanced HCC who underwent atezolizumab plus bevacizumab followed by radical hepatectomy.
View Article and Find Full Text PDFBackground: Intermittent Pringle maneuver (PM) is widely performed to reduce blood loss during hepatectomy; however, its impact on clinically relevant post-hepatectomy liver failure (PHLF) remains controversial. This study aimed to assess the impact of PM on PHLF and explore whether PM provides additional value for predicting PHLF.
Methods: Consecutive patients, who underwent hepatectomy without biliary and/or vascular reconstruction between 2011 and 2018 in a single institution, were retrospectively analyzed.
Background: Infectious complications can cause lethal liver failure after hepatectomy with biliary reconstruction. This study assessed the increased risk for postoperative infectious complications in patients who underwent hepatectomy with biliary reconstruction and explored the possibility of predicting pathogenic microorganisms causing postoperative infectious complications based on preoperative monitoring of bile cultures.
Methods: This study involved 310 patients who received major hepatectomy with or without biliary reconstruction at our institution between January 2010 and December 2019.