Publications by authors named "Yogita Kattimani"
In this issue of Neuron, Chadarevian et al. and Munro et al. demonstrate how the absence of homeostatic microglia leads to severe neuropathologies, including axonal spheroids, calcifications, myelination abnormalities, and gliosis, associated with leukoencephalopathy and age-related neurodegeneration.
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- Inactivation of the A20 gene is linked to a specific form of lymphoma and is studied in patients with haploinsufficiency of A20 (HA20), revealing immune system impacts.
- In a study of 34 HA20 patients, researchers found that the loss of one A20 gene copy leads to an increase in self-reactive lymphocyte receptors, often seen in lymphomas.
- The immune changes are driven by a feedback loop involving tumor necrosis factor (TNF), A20, and NF-κB, and can potentially be reversed by anti-TNF treatment, but may still lead to lymphoma development.
Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage which is driven by cytotoxic T cells targeting myelinating oligodendrocytes.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a demyelinating disease of the central nervous system causing axonal injury, neuronal loss, and atrophy of the central nervous system leading to permanent neurological and clinical disability. Presence of mutations in M9 domain of HNRNPA1 and detection of autoantibodies against this domain in HNRNPA1 qualifies it as a strong candidate for causing MS. These two aspects indicate the presence of a facilitator in associating them.
View Article and Find Full Text PDFObjectives: To identify Damaging mutations in microRNAs (miRNAs) and 3' untranslated regions (UTRs) of target genes to establish Multiple sclerosis (MS) disease pathway.
Methods: Female aged 16, with Relapsing Remitting Multiple sclerosis (RRMS) was reported with initial symptoms of blurred vision, severe immobility, upper and lower limb numbness and backache. Whole Exome Sequencing (WES) and disease pathway analysis was performed to identify mutations in miRNAs and UTRs.