Analysis of distribution and localization of proteins of the reelin signalling pathway in mesial temporal lobe epilepsy.

Introduction: Granule cell dispersion (GCD) is pathognomonic of hippocampal sclerosis seen in the mesial temporal lobe epilepsy (MTLE). Current animal studies indicate deficiency of Reelin is associated with abnormal granule cell migration leading to GCD. The present study aimed to evaluate complete Reelin signalling pathway to assess whether Reelin deficiency is related to MTLE.

Dysregulated Genes and Signaling Pathways in the Formation and Rupture of Intracranial Aneurysm.

Intracranial aneurysm (IA) has the potential to rupture. Despite scientific advances, we are still not in a position to screen patients for IA and identify those at risk of rupture. It is critical to comprehend the molecular basis of disease to facilitate the development of novel diagnostic strategies.

Clinicopathological Aspects of Death due to Wild Mushroom Poisoning: An Autopsy Report.

Mushrooms are widely cultivated and used as a source of diet and commerce; however, unfortunately, some wild mushrooms are highly toxic to humans. Although the poisonous mushrooms have a characteristic physical appearance, sometimes it is difficult to differentiate between the poisonous and nonpoisonous variety even by the experts. We report a case of a 23-year-old married female who mistakenly harvested and consumed wild mushrooms along with her family members and subsequently died on the 5-day postingestion.

Invasive pulmonary aspergillosis with brain dissemination in an immunocompetent host.

Invasive aspergillosis is an uncommon infection, which is mainly seen among immunocompromised patients. In recent years, cases of aspergillosis involving immunocompetent hosts are increasingly being reported. Herein, we report the case of a 27-year-old man with fever, productive cough, shortness of breath, and left hemiparesis.

Blunt-chest-trauma-induced acute myocardial infarction.

Blunt chest trauma (BCT) is one of the rarest causes of acute myocardial infarction (AMI). This paper reports the case of a young married man who suffered from AMI due to BCT sustained in a fight with his wife. The histopathology examination revealed a rupture of atherosclerotic plaque with superimposed thrombus in the proximal left anterior descending artery.

Prevalence of Atherosclerotic Coronary Stenosis in Asymptomatic North Indian Population: A Post-mortem Coronary Angiography Study.

Aim: A preliminary study of coronaries using post-mortem angiography was undertaken to see the prevalence of atherosclerotic coronary stenosis in non-cardiac unnatural deaths.

Materials And Methods: This study was conducted in a tertiary care centre located in Chandigarh. A total of 128 medico-legal cases were studied comprising 88 males and 40 females.

Intrauterine Fetal Death in Gunshot Injury to the Gravid Uterus: Forensic Perspective.

Assault on pregnant women is not a rare event; however forensic analysis of gunshot injuries among the same group requires a greater deliberation. This is the report of a 38-week-old fetus which succumbed following gunshot injuries to the mother while the latter survived. The uniqueness of fetal injuries in the form of avulsed wound with complete detachment of anus is of great forensic interest.

Alcohol and Drug Use in Injured Drivers - An Emergency Room Study in a Regional Tertiary Care Centre of North West India.

Background: Statistics show an increasing proportion of alcohol and drug use in drivers in more recent times throughout the world. It has been found that among the various human factors, alcohol consumption, using drugs and subsequent driving on the roads are major risk factors. Traffic regulations in India penalises drivers who drive beyond permissible alcohol limit of 30 mg%.

Effect of aceclofenac on pharmacokinetic of phenytoin.

Aceclofenac is presently most commonly prescribed analgesic for chronic pain and inflammatory conditions. In clinical practice, phenytoin and aceclofenac are used in a chronic condition of generalized seizure with concomitant chronic pain. Hence there are chances of drug-drug interaction because modulations of isoenzymes involved in metabolism of phenytoin and aceclofenac are CYP2C9/10 and CYP2C19.

Linearization of the relationship between serum sodium, potassium concentration, their ratio and time since death in Chandigarh zone of north-west India.

A strong relationship was established between the ratio of postmortem serum sodium and potassium concentrations and time since death by Querido in wistar rats. Henceforth, the present study was carried out to substantiate this inclination in humans. Flame photometric estimation of sodium and potassium concentration in postmortem blood of 474 subjects revealed a highly significant relationship between logarithm serum sodium as well as potassium concentration, logarithm of their ratio and the logarithim of the time since death during the first 3-58 h of death.