Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions.

Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline is introduced to process, analyze and compare data of 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients and various skin locations.

Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension: The HYPAZ Trial.

[Figure: see text].

Tomographic imaging with an ultrasound and LED-based photoacoustic system.

Pulsed lasers in photoacoustic tomography systems are expensive, which limit their use to a few clinics and small animal labs. We present a method to realize tomographic ultrasound and photoacoustic imaging using a commercial LED-based photoacoustic and ultrasound system. We present two illumination configurations using LED array units and an optimal number of angular views for tomographic reconstruction.

A Partially-Learned Algorithm for Joint Photo-acoustic Reconstruction and Segmentation.

In an inhomogeneously illuminated photoacoustic image, important information like vascular geometry is not readily available, when only the initial pressure is reconstructed. To obtain the desired information, algorithms for image segmentation are often applied as a post-processing step. In this article, we propose to jointly acquire the photoacoustic reconstruction and segmentation, by modifying a recently developed partially learned algorithm based on a convolutional neural network.

A framework for directional and higher-order reconstruction in photoacoustic tomography.

Photoacoustic tomography is a hybrid imaging technique that combines high optical tissue contrast with high ultrasound resolution. Direct reconstruction methods such as filtered back-projection, time reversal and least squares suffer from curved line artefacts and blurring, especially in the case of limited angles or strong noise. In recent years, there has been great interest in regularised iterative methods.