Publications by authors named "Yoan Ditchi"

Breast cancer is one of the most prevalent cancers worldwide and pathologists are closely involved in establishing a diagnosis. Tools to assist in making a diagnosis are required to manage the increasing workload. In this context, artificial intelligence (AI) and deep-learning based tools may be used in daily pathology practice.

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Objectives: To describe the clinical and pathological features of biopsy-proven cutaneous vasculitis (CV) associated with SLE, focusing on diagnosis classification and impact on overall SLE activity.

Methods: Retrospective multicentric cohort study including SLE patients with biopsy-proven CV identified by (i) data from pathology departments of three university hospitals and (ii) a national call for cases. SLE was defined according to 1997 revised ACR and/or 2019 ACR/EULAR criteria.

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Background: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are associated with cutaneous manifestations. Next-generation sequencing (NGS) is a tool capable of identifying clonal myeloid cells in the skin infiltrate and thus better characterize the link between hematological diseases and skin lesions.

Objective: To assess whether skin lesions of MDS/CMML are clonally related to blood or bone marrow cells using NGS.

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Article Synopsis
  • Invasive lobular carcinoma (ILC) is identified as a distinct subtype of breast cancer, primarily associated with CDH1 mutations, while data on its connection with BRCA1/2 and TP53 mutations remains limited.
  • A study from 1992 to 2016 analyzed breast cancer cases (n=3469), revealing a significantly lower proportion of ILC in BRCA1 and TP53 mutation carriers compared to other groups.
  • The findings suggest that BRCA1 and TP53 likely do not predispose individuals to ILC, providing important insights for genetic counseling in ILC patients.
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