[Fever Characteristics and Biomarker Changes of CRS in Patients with Relapsed/Refractory Multiple Myeloma after CAR-T Cell Therapy].

Objective: To investigate the correlation of the clinical characteristics, fever characteristics, serum biomarkers with cytokine release syndrome (CRS) in patients with relapsed/refractory multiple myeloma (R/R MM) treated with chimeric antigen receptor T cell (CAR-T) immunotherapy.

Methods: 104 R/R MM patients who received CAR-T cell therapy at the Affiliated Hospital of Xuzhou Medical University from June 2017 to November 2021 were included, and the correlations of their clinical characteristics, fever characteristics, serum biomarkers with the severity of CRS were analyzed.

Results: Among 104 R/R MM patients receiving CAR-T treatment, no CRS was observed in 8 cases (7.

[Clinical Features and Prognosis of Patients with Primary Extranodal Diffuse Large B-Cell Lymphoma].

Objective: To investigate the clinical features, gene mutation profile, efficacy and prognostic factors of primary extranodal diffuse large B-cell lymphoma(EN-DLBCL).

Methods: A retrospective analysis was performed for 382 patients with primary EN-DLBCL with complete clinical data who were treated in West China Hospital from January 2013 to January 2023, and their clinical characteristics,gene mutation profile, efficacy and prognostic factors were analyzed.

Results: The median age of the 382 patients with EN-DLBCL was 56(18-89) years old.

Serum cholesterol levels predict the survival in patients with idiopathic pulmonary fibrosis: A long-term follow up study.

Background: The relationship between serum lipid with idiopathic pulmonary fibrosis (IPF) required to be explored. We aim to evaluate the association of serum lipid levels with mortality in patients with IPF.

Materials And Methods: This retrospective study included IPF patients with more than three years follow-up.

Activated hepatic stellate cell-derived small extracellular vesicles facilitate M2 macrophage polarization and hepatoma progression via miR-27a-3p.

The progression of hepatoma is heavily influenced by the microenvironment. Tumor-associated macrophages (TAMs) are considered to play a critical role in the tumor microenvironment (TME) and increase the aggressiveness of hepatoma. The activation of hepatic stellate cells (HSCs) is involved in hepatoma progression, and accumulating evidence demonstrates a change in microRNA (miRNA) expression during HSC activation.

The biofunction of in intestinal-related diseases.

Intestinal homeostasis is essential for maintaining human health, and its dysfunction is related to the onset and progression of various diseases, including immune and metabolic disorders, and even tumorigenesis. Intestinal microbiota plays a critical role in intestinal homeostasis, with () emerging as a key commensal bacterium utilizing mucin as its sole carbon and nitrogen source. has been recognized in both experimental and clinical studies for its beneficial role in managing intestinal inflammation, tumors, functional gastrointestinal disorders, and secondary conditions such as liver and metabolic diseases.

Fuzzy backstepping controller for agricultural tractor-trailer vehicles path tracking control with experimental validation.

Unmanned driving technology for agricultural vehicles is pivotal in advancing modern agriculture towards precision, intelligence, and sustainability. Among agricultural machinery, autonomous driving technology for agricultural tractor-trailer vehicles (ATTVs) has garnered significant attention in recent years. ATTVs comprise large implements connected to tractors through hitch points and are extensively utilized in agricultural production.

Genomic Patterns are Associated with Different Sequelae of Patients with Long-Term COVID-19.

In the post-large era, various COVID-19 sequelae are getting more and more attention to health problems. Although the mortality rate of the COVID-19 infection is now declining, it is often accompanied by new clinical sequelae with different symptoms such as fatigue after infection, loss of smell. The degree of age, gender, virus infection seems to be weakly correlated with clinical symptoms.

Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations.

Background: Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affecting a mismatch repair gene (MLH1, MSH2, MSH6, PMS2). Occasionally, LS may be caused by constitutional MLH1 epimutation (CME) characterised by soma-wide methylation of one allele of the MLH1 promoter. Most of these are "primary" epimutations, arising de novo without any apparent underlying cis-genetic cause, and are reversible between generations.

Research trends and frontiers in rehabilitation after total knee arthroplasty: based on bibliometric and visualization analysis.

Background: Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis, and postoperative rehabilitation is crucial. However, a comprehensive bibliometric analysis of this area has yet to emerge. This study aims to visualize the research trends in postoperative rehabilitation after TKA through bibliometric analysis and explore current research frontiers and hotspots.

Preclinical Assessment of Safety and Efficacy of Deferoxamine (DFO)-pretreated Feline Adipose Mesenchymal Stem Cells.

Background/aim: This study aimed to investigate the safety and efficacy of deferoxamine (DFO) pretreated feline adipose tissue derived mesenchymal stem cells (fATMSCs) for the treatment of inflammatory disorders.

Materials And Methods: fATMSCs were isolated from feline adipose tissue and characterized using flow cytometry for surface marker expression and differentiation assays for adipogenic, osteogenic, and chondrogenic lineages. Different concentrations of DFO were used to evaluate its impact on fATMSC activity.

Single-cell RNA-seq offer new insights into the cell fate decision of the primordial germ cells.

The faithful production of primordial germ cells (PGCs) in vitro opens a wide range of novel applications in reproductive biology and medicine. However, the reproducibility of PGCs culture conditions across different laboratories or breeds remains a challenge. Therefore, it is necessary to research the molecular dynamics that lead to the gradual establishment of cultured PGCs lines network.

Structural and physicochemical properties of porous starch effected by different microwave involved stages under enzymatic hydrolysis.

Microwave-assisted enzymatic hydrolysis is an effective method to shorten the preparation time of porous starch. This study aims to investigate the effect of microwave treatment before/during/after enzymatic hydrolysis on the properties of porous starch. The results showed that the physicochemical properties of the porous starch obtained by microwave-assisted enzymatic hydrolysis were improved.

Number of global change factors alters the relative roles of abundant and rare microbes in driving soil multifunctionality resistance.

There is increasing evidence that ecosystems are affected by multiple global change factors, impeding the sustainability of multiple soil functions. Biodiversity can buffer ecosystem functions against environmental changes, a concept largely supported by insurance and portfolio theories. However, the role of soil biodiversity, especially the diversity of abundant and rare microbial taxa, in regulating soil multifunctionality resistance under an increasing number of global change factors remains poorly explored.

Thyroid lobectomy for unilateral TNM T1 and T2 papillary thyroid carcinoma patients with lateral lymph node metastasis.

Background: This study aimed to evaluate the prognostic outcomes of thyroidectomy extent in unilateral TNM T1 or T2 papillary thyroid carcinoma with lateral lymph node metastasis.

Methods: Retrospective data were collected from unilateral papillary thyroid carcinoma patients with unilateral lymph node metastasis who underwent surgery at Qilu Hospital of Shandong University from 2011 to 2022. Patients were categorized into 2 groups based on the extent of the thyroidectomy (total thyroidectomy versus lobectomy).

Construction of crystalline/amorphous NiP/FePO/graphene heterostructure by microwave irradiation for efficient oxygen evolution.

The rational design of highly efficient and cost-effective oxygen evolution reaction (OER) electrocatalysts is crucial for hydrogen production through electrocatalytic water splitting. Although the crystalline/amorphous heterostructure shows great potential in enhancing OER activity, its fabrication presents significantly greater challenges compared to that of crystalline/crystalline heterostructures. Herein, a microwave irradiation strategy is developed to construct reduced graphene oxide supported crystalline NiP/amorphous FePO heterostructure (NiP/FePO/RGO) as an efficient OER electrocatalyst.

Self-augmented catabolism mediated by Se/Fe co-doped bioceramics boosts ROS storm for highly efficient antitumor therapy of bone scaffolds.

The overexpression of glutathione (GSH) within the tumor microenvironment has long been considered as the major obstacle for reactive oxygen species (ROS)-based antitumor therapies. To address this challenge, a selenite (SeO) and ferric ion co-doped hydroxyapatite (SF-HAP) nanohybrid was synthesized, which is then introduced into poly-L-lactic acid (PLLA) to prepare porous scaffold by selective laser sintering to continuously release Fe and SeO ions. Of great significance is the released SeO catabolize GSH to generate superoxide anion (O) rather than directly eliminating GSH, thereby reversing the obstacle posed by its overexpression and achieving a "waste-to-treasure" transformation.

Zeolite-like algal biochar nanoparticles for enhanced antibiotics removal: Sorption mechanisms and theoretical calculations.

In the study, Sargassum horneri (S. horneri) was used to create a novel zeolite-like algal biochar (KSBC). KSBC with doping of N, O, S, Al, and Si, displayed zeolite-like properties, including well-developed porosity, a high specific surface area (1137.

Chemical characterization and classification of vegetable oils using DESI-MS coupled with a neural network.

This study tackled mislabeling fraud in vegetable oils, driven by price disparities and profit motives, by developing an approach combining desorption electrospray ionization mass spectrometry (DESI-MS) with a shallow convolutional neural network (SCNN). The method was designed to characterize lipids and distinguish between nine vegetable oils: corn, soybean, peanut, sesame, rice bran, sunflower, camellia, olive, and walnut oils. The optimized DESI-MS method enhanced the ionization of non-polar glycerides and detected ion adducts like [TG + Na], [TG + NH].

Improving the emulsification properties of corn starch by esterification combined with freeze-thawing and enzymatic treatment.

In this study, high performance porous starch was prepared by combining freeze-thawing and enzymatic hydrolysis with the aim of evaluating its potential as a starch emulsifier in Pickering emulsions. The results indicate that the combined treatment significantly altered the specific surface area of starch (from 0.3257 m/g to 1.

Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.

Ferroptosis, a unique form of iron-dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role of GPX4 in regulating ferroptosis, our understanding of GPX4 protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as a regulator of GPX4 protein.

Association of N, N-diethyl-m-toluamide (DEET) with arthritis among adult participants.

Background: N, N-diethyl-m-toluamide (DEET), an active ingredient prevalent in insect repellents, has its effects on human health under ongoing debate and scrutiny.

Objective: This study aimed to investigate the association between exposure to DEET and arthritis outcomes within the broader adult demographic, leveraging data obtained from the National Health and Nutrition Examination Survey (NHANES).

Methods: 3-diethyl-carbamoyl benzoic acid (DCBA) was used as a specific indicator of DEET exposure.