Publications by authors named "Yo Ogawa"
Article Synopsis
- The study investigates the role of specific sperm proteins in mammalian fertilization, focusing on proteins expressed during sperm development.
- The researchers created knockout mice using CRISPR/Cas9 to analyze the impact of seven candidate proteins on male fertility and reproductive health.
- Results showed that these proteins are not essential for male fertility, as the knockout males were able to sire pups normally, indicating their dispensability in sperm-egg interaction.
1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction.
Proc Natl Acad Sci U S A
February 2023
Sperm acrosomal membrane proteins, such as Izumo sperm-egg fusion 1 (IZUMO1) and sperm acrosome-associated 6 (SPACA6), play essential roles in mammalian gamete binding or fusion. How their biosynthesis is regulated during spermiogenesis has largely remained elusive. Here, we show that knockout male mice are severely subfertile and their spermatozoa do not fuse with eggs.
View Article and Find Full Text PDF[Imaging diagnosis of the temporal bone and nasal-paranasal sinuses using cone-beam CT].
Nihon Jibiinkoka Gakkai Kaiho
March 2012