[Effect of posteroventral pallidotomy on event-related P300 in Parkinson's disease].

Background: Ablative procedures are still frequent for the surgical treatment of Parkinson's disease (PD). Although the P300 component has been used to assess cognitive changes induced by levodopa and deep brain stimulation (DBS), the effects caused by unilateral pallidotomy remain unknown.

Material And Methods: P300 amplitude and latency in 10 PD patients who underwent unilateral pallidotomy with and without levodopa treatment were compared with 10 healthy controls.

Bilateral cingulotomy and anterior capsulotomy applied to patients with aggressiveness.

Objective: To perform a preliminary study on the effects and safety of bilateral cingulotomy and anterior capsulotomy in patients with aggressive behavior.

Patients And Methods: Twenty-three psychiatric patients showing aggressive behavior refractory to conventional treatment were initially evaluated. The subjects were clinically selected using the Overt Aggression Scale (OAS) and the Global Assessment of Functioning Scale (GAF).

Effects of Thalamic Reticular Nucleus Electrical Stimulation in Rats in a T-maze Perseverative Behavior Model Induced by 8-OH-DPAT.

Objective. Evaluate the possible decrease of chemically induced perseverative behavior in rats after electrical stimulation at different frequencies in the thalamic reticular nucleus. Material and Methods.

Effects of bilateral lesions in thalamic reticular nucleus and orbitofrontal cortex in a T-maze perseverative model produced by 8-OH-DPAT in rats.

Objective: Stereotaxic lesions of the orbitofrontal-thalamic system, specifically the thalamic reticular nucleus (TRN), could be helpful to prevent perseverative behavior in rats produced by 8-OH-DPAT.

Methods: Fifty rats were conditioned in a T-maze to measure the number of perseverations. Habituation was performed on days 1 and 2, baseline scores were obtained on day 3 and the final test was done on day 4 (chemical induction).