Publications by authors named "Yizhuo Liu"

Gold nanoclusters (AuNCs) are emerging as promising functional probes for bioapplications. However, because of rapid renal clearance, it is a challenge to tailor their biofate and improve their disease-targeting ability in vivo. Herein, we report an efficient strategy to tailor their organotropic actions by rationally designing AuNC assemblies.

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  • The hippocampus is important for various neuropsychiatric traits, and understanding its subfields' genetic relationships is vital as it has high heritability and could serve as biomarkers for these conditions.
  • Researchers examined MRI data from over 41,000 UK participants to conduct genome-wide association studies on 24 hippocampal and subfield volume traits and assessed their genetic correlations with 10 neuropsychiatric traits.
  • They identified 352 genetic variants related to these traits and found specific genes associated with various conditions, concluding that changes in hippocampal structures are linked to an increased risk of Parkinson's disease.
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Deciphering the composition of the tumor microenvironment (TME) is critical for understanding tumorigenesis and to design immunotherapies. In the present study, we mapped genetic effects on cell-type proportions using single-cell and bulk RNA sequencing data, identifying 3,494 immunity quantitative trait loci (immunQTLs) across 23 cancer types from The Cancer Genome Atlas. Functional annotation revealed regulatory potential and we further assigned 1,668 genes that regulate TME composition.

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  • The study focuses on creating a risk prediction model for early detection of colorectal neoplasms, specifically targeting high-risk individuals in the East Asian population to reduce cancer burden through timely interventions.
  • Researchers developed three polygenic risk scores (PRS) using previous CRC risk loci, SNP selection from large data, and a Bayesian prediction approach, validating their effectiveness in large sets of patients and normal individuals from different studies.
  • The optimized PRS showed improved risk assessment across various stages of neoplasm development and confirmed a significant dose-response effect in both East Asian and European cohorts, indicating its potential for personalized screening.
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  • Dysregulation of enhancer transcription and the role of enhancer RNAs (eRNAs) in cancer is explored, aiming to identify genetic factors influencing eRNA expression to better understand cancer mechanisms.! -
  • Researchers conducted a detailed analysis of eRNA quantitative trait loci (eRNAQTLs) in colorectal cancer samples from China, integrating epigenomic and genetic data from over 154 CRC cases to establish the first eRNAQTL profiles.! -
  • A total of 300,112 eRNAQTLs were identified across various cancers, highlighting their connection to cancer risk and potential therapeutic targets, with a specific focus on an eRNAQTL variant (rs3094296-T) that reduces colorectal cancer risk in Chinese
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  • Left ventricular regional wall thickness (LVRWT) is a key factor influencing health outcomes in cardiovascular diseases (CVDs), and researchers developed a deep learning method to measure it in over 42,000 individuals using cardiac imaging.
  • Genome-wide studies found 72 genetic loci related to various LVRWT measurements, suggesting their involvement in heart development and function.
  • The study also linked certain LVRWT traits to hypertrophic cardiomyopathy (HCM), indicating that genetic factors can help identify individuals at higher risk for this condition.
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(2n=6x=42, StStJJJJ) is resistant or tolerant to biotic and abiotic stresses, making it suitable for developing perennial crops and forage. Through five cycles of selection, we developed 24 perennial wheatgrass lines, designated 19HSC-Q and 20HSC-Z, by crossing wheat- partial amphiploids with . The cold resistance, morphological performance, chromosome composition, and yield components of these perennial lines were investigated from 2019 to 2022.

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  • Genome-wide association studies have revealed many genetic variants linked to complex human traits, primarily located in non-coding regions, but understanding their biological roles is still difficult.
  • The Activity-by-Contact (ABC) model was used to analyze enhancer-gene interactions across various cancer types, identifying over 544,000 connections and showing improved performance in associating regulatory variants with target genes.
  • A specific regulatory variant (rs4810856) was linked to colorectal cancer risk by enhancing the expression of multiple genes, highlighting its role in influencing cancer development and providing valuable insights into cancer biology.
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Background: Findings on the association of genetic factors and colorectal cancer (CRC) survival are limited and inconsistent, and revealing the mechanism underlying their prognostic roles is of great importance. This study aimed to explore the relationship between functional genetic variations and the prognosis of CRC and further reveal the possible mechanism.

Methods: We first systematically performed expression quantitative trait locus (eQTL) analysis using The Cancer Genome Atlas (TCGA) dataset.

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  • Alternative polyadenylation (APA) is a significant posttranscriptional regulation mechanism linked to cancer development and progression, as explored through a comprehensive atlas of apaQTLs across 32 cancer types.
  • These apaQTLs affect cancer pathways by modifying poly(A) motifs, RNA-binding proteins, and chromatin elements, and are enriched in cancer susceptibility loci identified by genome-wide association studies (GWAS).
  • A specific variant, rs1020670, was found to increase colorectal cancer risk by promoting aberrant APA through its influence on the expression of the gene DNM1L, suggesting potential therapeutic targets for combating cancer.
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  • Dysregulation of alternative splicing is linked to various human diseases, especially cancers, and this study explores how genetic variations, known as splicing quantitative trait loci (sQTLs), impact splicing mechanisms in colorectal cancer (CRC).
  • Researchers conducted a detailed sQTL analysis across multiple cancer types and validated their findings in CRC tissues, ultimately revealing that certain genetic variants can significantly increase CRC risk.
  • The study identified the risk allele rs61746794, which affects PRMT7 splicing, leading to the overexpression of a cancer-promoting isoform (PRMT7-V2), underscoring the role of specific genetic factors in CRC susceptibility and growth.
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Although genome-wide association studies (GWASs) have identified over 100 colorectal cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological functions in these loci remain unclear. Recently, genomic loci 10q26.12 with lead SNP rs1665650 was identified as an essential CRC risk loci of Asian populations.

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Previous investigations mainly focused on the associations of dietary fatty acids with colorectal cancer (CRC) risk, which ignored gene-environment interaction and mechanisms interpretation. We conducted a case-control study (751 cases and 3058 controls) and a prospective cohort study (125 021 participants) to explore the associations between dietary fatty acids, genetic risks, and CRC. Results showed that high intake of saturated fatty acid (SFA) was associated with a higher risk of CRC than low SFA intake (HR =1.

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Unlabelled: Microorganisms are commonly detected in tumor tissues, and the species and abundance have been reported to affect cancer initiation, progression, and therapy. Host genetics have been associated with gut microbial abundances, while the relationships between genetic variants and the cancer microbiome still require systematic interrogation. Therefore, identification of cancer microbiome quantitative trait loci (mbQTL) across cancer types might elucidate the contributions of genetic variants to tumor development.

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Unlabelled: Understanding the genetic variation underlying transcript splicing is essential for fully dissecting the molecular mechanisms of common diseases. The available evidence from splicing quantitative trait locus (sQTL) studies using pancreatic ductal adenocarcinoma (PDAC) tissues have been limited to small sample sizes. Here we present a genome-wide sQTL analysis to identify SNP that control mRNA splicing in 176 PDAC samples from TCGA.

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In recent years, ionic conductive hydrogels have shown great potential for application in flexible sensors, energy storage devices, and actuators. However, developing facile and effective methods for fabricating such hydrogels remains a great challenge, especially for hydrogels that retain their properties in extreme environmental conditions, such as at subzero temperatures or storage in open-air conditions. Herein, a water-miscible ionic liquid (IL), such as 1-ethyl-3-methylimidazolium acetate (EMImAc), was introduced to form an IL/water binary solvent system for poly(vinyl alcohol) (PVA) to create ionic conductive PVA hydrogels.

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Objective: To measure the situation of the non-prescription sale of antibiotics and the service quality of community pharmacies in Guangzhou, China.

Methods: A simulated client method was conducted to estimate the non-prescription sale of antibiotics and service quality based on scenarios about adult acute upper respiratory tract infection in 2019. A total of 595 community pharmacies from 11 districts were investigated in Guangzhou, China.

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Flexible ionic conductive hydrogel is attracting significant interest as it could be one of the crucial components for multifunctional ionotronic devices. However, their features of inevitably drying out without package and freezing at subzero temperatures may greatly limit the applications of conventional hydrogels in specific situations. Here, we present an ionic conductive hydrogel with water retention and freezing tolerance that consists of silk fibroin, ionic liquid, water, and inorganic salt.

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A multifunctional magnetic mesoporous bioactive glass (MMBG) has been widely used for a drug delivery system, but its biological properties have been rarely reported. Herein, the effects of mesopores and Fe3O4 nanoparticles on drug loading-release property, bactericidal property and biocompatibility have been investigated by using mesoporous bioactive glass (MBG) and non-mesoporous bioactive glass (NBG) as control samples. Both MMBG and MBG have better drug loading efficiency than NBG because they possess ordered mesoporous channels, big specific surface areas and high pore volumes.

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Implant-associated infection remains a difficult medical problem in orthopaedic surgery. Here, we report on the fabrication of gentamicin-loaded mesoporous bioactive glass (Gent-MBG) for use as a controlled antibiotic delivery system to achieve the sustained release of antibiotics in the local sites of bone defects. The high surface area and mesoporous structure of MBG enable higher drug loading efficiency (79-83 %) than non-mesoporous biological glass (NBG) (18-19 %).

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