The novel HLA-B*51:01:83 allele was identified by next-generation sequencing.

HLA-B*51:01:83 differs from HLA-B*51:01:01:01 by one single nucleotide substitutions in exon 5.

Hyperacute stabilization (<12 hours) for polytrauma patients with unstable spinal fractures.

Background: The objective of this study is to validate the safety of hyperacute stabilization.

Methods: Patient demographics, American Spinal Injury Association (ASIA) grade on initial evaluation and serial follow up grades, hospital length of stay, Intensive Care Unit length of stay, intraoperative blood loss, postoperative length of stay, comorbidities, Injury Severity Score and complications of recumbency were recorded.

Results: Corroborating previous studies, our study shows polytrauma patients undergoing a hyperacute stabilization of a spinal fracture displayed a trend towards better neurological outcome and decreased hospital stays while having a similar complication rate to those operated on in a delayed fashion.

Interactions between programmable shunt valves and the iPad 3 with Smart Cover.

Introduction: In patients with programmable CSF shunt valves, the risk of unintentional valve adjustment associated with the environmental magnetic influence is ever present. We tested whether the iPad 3 with Smart Cover is capable of changing the setting of individual programmable valves ex vivo using direct fluoroscopic visualization.

Methods: The following valves were tested: Strata NSC Adjustable Pressure Valve, Strata NSC Burr Hole Valve, Strata II small valve, Sophysa Polaris model SPV, Aesculap valve proGAV, and Codman Certas Programmable Valve.

Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives.

A combination of recombinant FKP and alpha-(1-->3)-fucosyltransferase allows the facile synthesis of the sialyl Lewis X tetrasaccharide glycan and its derivatives in excellent yield. In this system, the universal fucosyl donor, guanidine 5'-diphosphate-beta-L-fucose (GDP-fucose), or its analogues can be generated in situ by cofactor recycling using pyruvate kinase.