Multifunctional Nano-Realgar Hydrogel for Enhanced Glioblastoma Synergistic Chemotherapy and Radiotherapy: A New Paradigm of an Old Drug.

Purpose: Realgar, as a kind of traditional mineral Chinese medicine, can inhibit multiple solid tumor growth and serve as an adjuvant drug in cancer therapy. However, the extremely low solubility and poor body absorptive capacity limit its application in clinical medicine. To overcome this therapeutic hurdle, realgar can here be fabricated into a nano-realgar hydrogel with enhanced chemotherapy and radiotherapy (RT) ability.

Perioperative and Short-Term Outcomes of Sinus Replacement and Conservative Repair for Aortic Root in Acute Type A Aortic Dissection: A Prospective Cohort Study.

Background: To compare outcomes between sinus replacement (SR) and conservative repair (CR) for dissected roots with normal size.

Methods: From October 2018 to April 2021, a prospective cohort study was carried out. Patients were assigned to two groups (SR group and CR group) according to whether they underwent sinus replacement.

Comparison of Single Axillary vs. Dual Arterial Cannulation for Acute Type a Aortic Dissection: A Propensity Score Matching Analysis.

Background: The optimal arterial cannulation site for acute aortic dissection repair is unclear, especially for complex arch surgery. Axillary artery cannulation is widely accepted but adding femoral artery cannulation to it was considered to potentially improve perfusion and early outcomes. To clarify this point, a comparison of perioperative outcomes for these two different cannulation strategies was conducted regarding the pathological features of dissection.

Safety and durability of single-stage type I hybrid total aortic arch repair for extensive aortic arch disease: early- and long-term clinical outcomes from a single center and our 10-year of experience.

Background: Single-stage type I hybrid total aortic arch repair is a surgical treatment for extensive aortic arch disease, but the clinical outcomes were distinguishing. The purposes of this study were to share our experience and evaluate the perioperative safety and long-term durability.

Methods: Thirty-six patients who underwent single-stage type I hybrid total aortic arch repair in Fuwai Hospital between January 2010 and June 2020 were respectively reviewed.

Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study.

Autism spectrum disorder (ASD) is defined as a pervasive developmental disorder which is caused by genetic and environmental risk factors. Besides the core behavioral symptoms, accumulated results indicate children with ASD also share some metabolic abnormalities. To analyze the comprehensive metabolic profiles in both of the first-morning urine and plasma samples collected from the same cohort of autistic boys.

Widely wavelength-tunable 2 μm Brillouin fiber laser incorporating a highly germania-doped fiber.

We present, for the first time to our knowledge, a wavelength-tunable 2 μm Brillouin fiber laser based on a homemade thulium-doped fiber laser pump and a segment of highly germania-doped fiber (HGDF). The laser wavelength can be continuously tuned over 110 nm from 1920 to 2030 nm with single frequency operation, and the linewidth is estimated to be less than 0.9 kHz at 1950 nm.

Wavelength-tunable all-fiber mode-locked laser based on supermode interference in a seven-core fiber.

A wavelength-tunable all-fiber mode-locked erbium-doped fiber laser has been proposed and realized by using a supermode interference filter (SMIF). The SMIF is fabricated by splicing a segment of seven-core fiber (SCF) to two standard single-mode fibers. Since two supermodes of the propagating light are excited in the SCF, the transmission spectrum of the SMIF shows a clean broadband comb-shape characteristic.

[Efficacy and safety of intravenous recombinant human brain natriuretic peptide in patients with severe heart failure: a prospective multicenter clinical study].

Objective: To explore the efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) in the patients with severe heart failure (HF).

Methods: A prospective multicenter study was conducted. Patients whose age > 18 years old, and with the New York Heart Association (NYHA) cardiac function grade over III-IV, acute cardiac insufficiency and the acute exacerbation of chronic cardiac insufficiency admitted to intensive care unit/cardiovascular care unit (ICU/CCU) of 58 Hospitals in China were enrolled.

Microchip dual-frequency laser with well-balanced intensity utilizing temperature control.

A continuous-wave microchip dual-frequency laser (DFL) with well balanced intensity was presented. In order to obtain such a balanced intensity distribution of the two frequency components, the DFL wavelengths were precisely tuned and spectrally matched with the emission cross section (ECS) spectrum of the gain medium by employing a temperature controller. Finally, when the heat sink temperature was controlled at -5.

Broadband mid-infrared fiber optical parametric oscillator based on a three-hole suspended-core chalcogenide fiber.

A mid-infrared fiber optical parametric oscillator is proposed and designed based on a three-hole As(2)S(5) suspended-core fiber (SCF). The eigenmodes of the SCF are depicted and the pump condition for single-mode operation is analyzed. The zero-dispersion wavelength is shifted to 2 μm by tuning the core diameter of the SCF.

CW dual-frequency MOPA laser with frequency separation of 45 GHz.

A CW dual-frequency master oscillator power amplifier (MOPA) laser system with dozens of gigahertz (GHz) frequency separation is presented. The MOPA system consists of a monolithic microchip seed laser and a double-end pumped traveling wave power amplifier. The short length of seed laser cavity guarantees the seed signal with a large frequency separation (above 53 GHz) but low output power (below 247.

Optical logic gates based on electro-optic modulation with Sagnac interferometer.

In this work, we present a new structure to realize optical logic operation in a Sagnac interferometer with electro-optical modulation. In the scheme, we divide two counterpropagation signals in a Sagnac loop to two different arms with the electro-optical crystal by using two circulators. Lithium niobate materials whose electro-optical coefficient can be as large as 32.

[Stented elephant trunk and femoral artery bypass grafting surgery for extended aneurysmal dilation of Stanford A aortic dissection or aortic aneurysm].

Objectives: To summarize the clinical experience of stented elephant trunk with femoral artery bypass grafting procedure to treat severe aneurysmal dilation of Stanford A aortic dissection or aortic aneurysm. To study the surgical indication and surgical strategy of chronic Stanford A aortic dissection and aneurysmal dilation, also to summarize the early follow-up results.

Methods: From February 2006 to November 2011, 19 patients with Stanford A aortic dissection or aortic aneurysm with extented aneurysmal dilation (megaaorta) received stented elephant trunk with femoral artery bypass grafting procedure.

Hybrid total arch repair without deep hypothermic circulatory arrest for acute type A aortic dissection (R1).

Objective: To investigate the surgical outcomes of hybrid total arch repair without deep hypothermic circulatory arrest for patients with acute Stanford type A aortic dissection.

Methods: Retrospective review of clinical data of patients with acute Stanford type A aortic dissection who underwent surgical repair at our institution between November 2009 and December 2011 identified 21 patients who underwent hybrid total arch repair without deep hypothermic circulatory arrest. The in-hospital and follow-up data were investigated.

Double-pumped multiwavelength fiber optical parametric oscillator based on a Sagnac loop filter.

We propose a double-pumped ring cavity multiwavelength fiber optical parametric oscillator (MW-FOPO) using a highly nonlinear dispersion-shifted fiber (HNL-DSF) as the gain medium and a polarization maintained fiber based Sagnac loop filter as the comblike filter. 22-wavelength lasing of the double-pumped MW-FOPO with a ripple less than ±2.5 dB and a wavelength spacing of about 0.

High sensitivity third-order autocorrelation measurement by intensity modulation and third harmonic detection.

We demonstrate a novel (to our knowledge) method for high sensitivity measurement of pulsed light at the telecommunication wavelength of 1558 nm using a GaAsP photomultiplier tube. By modulating the input power and analyzing the harmonic components, high sensitivity third-order autocorrelation is obtained in the wavelength and power regimes where a mixture of two-photon absorption and three-photon absorption in the photomultiplier tube is present.

[Diagnostic value of echocardiography for cardiac tumors in infancy and childhood].

Objective: The present study was designed to evaluate the clinical manifestations, surgical findings, pathologic types and treatment of cardiac tumor and to analyze the echocardiographic characteristics of the cases.

Methods: Records of 19 patients with cardiac tumors confirmed by operations and pathology at Fuwai Cardiovascular Hospital in Beijing, China between Jan, 1983 and Dec, 2003 were reviewed. Clinical and echocardiographic data of all patients were analyzed.

Autotransfusion of shed mediastinal blood after open heart surgery.

Objective: To determine the safety and effectiveness of autotransfusion of shed mediastinal blood after open heart surgery.

Methods: Sixty patients undergoing coronary artery bypass grafting (CABG) were selected randomly to receive either nonwashed shed mediastinal blood (Group 1, n = 30) or banked blood (Group 2, n = 30). Drainage and transfusion volume were determined after the operation.