Publications by authors named "Yizhe Xue"

Article Synopsis
  • Metabolic dysfunction-associated steatohepatitis (MASH) complicates the delivery of therapeutic proteins due to excess extracellular matrix (ECM), leading to the development of a new treatment strategy called "Fibrosis overexpression and retention (FORT)."
  • FORT utilizes specially designed retinoid-derivative lipid nanoparticles (LNPs) that enhance mRNA expression in fibrotic areas and include modifications to promote protein anchoring in the ECM.
  • The approach has shown a tenfold increase in protein expression and improved retention of engineered therapeutic proteins in fibrotic lesions, proving effective in various animal models of MASH while reducing toxicity.
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Cranial radiotherapy is a major treatment for leukemia and brain tumors. Our previous study found abscopal effects of cranial irradiation could cause spermatogenesis disorder in mice. However, the exact mechanisms are not yet fully understood.

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Two-dimensional materials are expected to play an important role in next-generation electronics and optoelectronic devices. Recently, twisted bilayer graphene and transition metal dichalcogenides have attracted significant attention due to their unique physical properties and potential applications. In this study, we describe the use of optical microscopy to collect the color space of chemical vapor deposition (CVD) of molybdenum disulfide (MoS) and the application of a semantic segmentation convolutional neural network (CNN) to accurately and rapidly identify thicknesses of MoS flakes.

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Background: Recently, concerns about the combined effects of electromagnetic field (EMF) in daily living and occupational environment are rapidly growing.

Methods: In this study, we investigated the combined effects of 1-week exposure to electromagnetic pulse (EMP) at 650 kV/m for 1,000 pulses and 4.9 GHz radiofrequency (RF) at 50 W/m for 1 h/d in male mice.

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The rapid development of 5G network technology has gained much popularity as well as concerns about its adverse effects. In this study, we investigated the effects of 4.9 GHz (one of working frequencies of 5G communication) radiofrequency (RF) field on emotional behaviours and spatial memory in adult male mice.

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Article Synopsis
  • The study investigated how thoracic X-ray irradiation affects sperm production in male mice, comparing a radiation group to a sham group over multiple days.
  • Results showed that mice receiving radiation had poorer sperm quality, with fewer sperm and higher rates of abnormalities and apoptosis.
  • Additionally, the testicular structure and function were significantly damaged in the radiation group, indicated by changes in testis index, blood-testis barrier permeability, and altered levels of certain proteins and inflammatory markers.
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Objective: To investigate the effects of exposure to 5.8 GHz microwaves on testicular structure and function of male adult rats.

Methods: After 30 days of exposure, we evaluated sperm quality by determining sperm concentration and quantifying the number of abnormal sperm.

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Purpose: To clarify the preventive and therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on brain injury induced by X-ray cranial irradiation, preliminarily identify the mechanism and provide a novel clinical approach for the prevention and treatment of radiation-induced brain injury (RBI).

Materials And Methods: Male C57BL/6 mice were randomly divided into the sham group, large fractionated dose (5 Gy × 4 d) group, large fractionated dose + rTMS (5 Gy × 4 d + rTMS) group, conventional fractionated dose (2 Gy × 10 d) group and conventional fractionated dose + rTMS (2 Gy × 10 d + rTMS) group. After cranial irradiation and rTMS, behavioral experiments, morphological staining and molecular biology experiments were performed.

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To investigate whether the abscopal effects of cranial irradiation (C-irradiation) cause testicular damage in mice, male mice (9weeks of age) were randomly divided into a sham irradiation group, a shielded group and a C-irradiation group and administered sham/shielded irradiation or C-irradiation at a dose rate of 2.33Gy/min (5Gy/d for 4 d consecutively). All mice were sacrificed at 4weeks after C-irradiation.

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Objective: 5.8 GHz spectrum is gaining more attention in wireless technology. To explore the potential hazards, we investigated the effect of exposure to 5.

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Bunge (Labiatae) is a traditional Chinese herb. Endophytic fungi, which are biotic elicitors, can induce accumulation of secondary metabolites in their host plants. To analyze the interaction mechanism between and endophytic fungi.

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Under some occupational conditions, workers are inevitably exposed to high-intensity radiofrequency (RF) fields. In this study, we investigated the effects of one-month exposure to a 220 MHz pulsed modulated RF field at the power density of 50 W/m² on the sperm quality in male adult rats. The sperm quality was evaluated by measuring the number, abnormality and survival rate of sperm cells.

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