Publications by authors named "Yiyuan Zeng"
Article Synopsis
- Sotatercept is a new protein being developed to treat pulmonary arterial hypertension (PAH) by inhibiting activin signaling, and it was tested in a phase III clinical trial called STELLAR.
- In the study, 162 participants were treated either with sotatercept or a placebo, and about 25.9% developed antidrug antibodies (ADAs), with a small percentage also showing neutralizing antibodies.
- The presence of ADAs did not significantly impact the drug's effectiveness, safety, or how the body processed the drug, indicating that sotatercept remains a viable treatment option for patients with PAH.
Introduction: The functions of terrestrial ecosystems are mainly maintained by bacteria, as a key component of microorganisms, which actively participate in the nutrient cycling of ecosystems. Currently, there are few studies have been carried out on the bacteria contributing to the soil multi-nutrient cycling in responding to climate warming, which hampers our obtainment of a comprehensive understanding of the ecological function of ecosystems as a whole.
Methods: In this study, the main bacteria taxa contributing to the soil multi-nutrient cycling under the long-term warming in an alpine meadow was determined based onphysichemical properties measurement and high-throughput sequencing, and the potential reasons that warming altered the main bacteria contributing to the soil multi-nutrient cycling were further analyzed.