Effectiveness and safety of PD-1/PD-L1 inhibitors monotherapy in patients with endometrial cancer.

Background: Studies evaluating the effectiveness of immune checkpoint inhibitors (ICI) for endometrial cancer (EC) are limited. This study aimed to assess the efficacy of PD-1/PD-L1 inhibitors as monotherapy for EC by conducting a meta-analysis. The predictive significance of MMR status, a biomarker for ICI response, also required further investigation.

[Retracted] Inhibition of microRNA‑19b promotes ovarian granulosa cell proliferation by targeting IGF‑1 in polycystic ovary syndrome.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the colony formation assay data (or portions of the data thereof) shown in Figs. 2C and 5G were strikingly similar to data that had appeared in different form in other articles by different authors at different research institutes. Owing to a general lack of confidence in the presented data, and due to the fact that the contentious data in the above article may have already been published, prior to its submission to , the Editor has decided that this paper should be retracted from the Journal.

Metabolism-related gene vaccines and immune infiltration in ovarian cancer: A novel risk score model of machine learning.

Background: The present study aims to develop a metabolic gene signature to evaluate the survival rate of ovarian cancer (OC) patients and analyze the potential mechanisms of metabolic genes in OC because the difficulty in early detection of OC often leads to poor treatment outcomes.

Methods: A non-negative matrix factorization algorithm was applied to determine molecular subtypes according to metabolism genes. To build a risk prognosis model, least absolute shrinkage and selection operator multivariate Cox analysis was carried out with weighted correlation network analysis (WCGNA).

Inhibition of microRNA-19b promotes ovarian granulosa cell proliferation by targeting IGF-1 in polycystic ovary syndrome.

The purpose of the present study was to investigate the functional role of microRNA (miR)-19b in polycystic ovary syndrome (PCOS) and try to elucidate its underlying mechanisms. Expression of miR‑19b and insulin‑like growth factor 1 (IGF-1) was examined in ovarian cortexes [(from 18 women with PCOS and 10 who did not have PCOS (non‑PCOS)] and KGN cells. Cell proliferation assays (cell viability and colony formation assay) were performed following overexpression or inhibition of miR‑19b and IGF‑1 or following insulin treatment in KGN cells.