Publications by authors named "Yiyi Xiao"
Background: The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention in the recent years. As the field rapidly evolves, analyzing research trends and identifying research hotpots are essential for guiding future advancements, and a comprehensive bibliometric can provide valuable insights.
Methods: The current research focused on publications from 2001 to 2024, and was sourced from the Web of Science Core Collection (WoSCC).
Article Synopsis
- Acute transplant rejection is a major challenge in organ transplantation, and this study investigates the potential of endometrial regenerative cell-derived exosomes (ERC-Exos) to mitigate this issue by targeting a specific immune-regulating molecule, SLAMF6.
- The experimental results showed that treatment with ERC-Exos containing siSLAMF6 led to longer survival of transplanted organs in mice, altered cytokine profiles in the serum, and reduced the activation of harmful T cells.
- This research suggests that ERC-Exos can effectively modify immune responses by promoting the differentiation of regulatory T cells while inhibiting the proliferation of Th1 and Th17 cells, which are associated with transplant rejection.
Article Synopsis
- Exosomes derived from endometrial regenerative cells (ERC-Exos) have potential immunomodulatory effects, particularly in treating inflammatory bowel diseases like colitis, and the role of insulin-like growth factor-Ⅱ (IGF2) in this process was explored.
- In experiments with mice experiencing colitis, treatment with ERC-Exos led to significant improvements in symptoms and intestinal health compared to untreated mice, but the protective effects were reduced when IGF2 was knocked out from the exosomes.
- Additionally, the presence of IGF2 in ERC-Exos was found to influence immune cell populations, reducing harmful T helper cell types and dendritic cell activity, suggesting a beneficial immunological shift towards a more anti-inflammatory environment
Background & Aims: A high human cytomegalovirus (HCMV) infection rate accompanied by an increased level of bile duct damage is observed in the perinatal period. The possible mechanism was investigated.
Methods: A total of 1,120 HCMV-positive and 9,297 HCMV-negative children were recruited, and depending on age, their liver biochemistry profile was compared.
Triple negative breast cancer (TNBC) is a kind of refractory cancer with poor response to conventional chemotherapy. Recently, the combination of baicalein and doxorubicin was reported to exert a synergistic antitumor effect on breast cancer. However, the underlying mechanism how baicalein sensitizes breast cancer cells to doxorubicin remains to be elucidated.
View Article and Find Full Text PDFGastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin-induced cisplatin resistance in GC.
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