Publications by authors named "Yiye Zhong"
Article Synopsis
- - The research identifies TMEFF1 as a critical factor that helps prevent the replication of the herpes simplex virus type 1 (HSV-1) in neurons, which are particularly vulnerable to damage from infection.
- - Using CRISPR screening, the study found that TMEFF1 is specifically expressed in central nervous system neurons and works by blocking viral entry, thereby reducing neuronal death during HSV-1 infection.
- - Experiments showed that mice lacking TMEFF1 were more susceptible to HSV-1 in the brain, highlighting its importance in combating viral infections in the central nervous system.
Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due to various limiting factors. To address this challenge, we engineered an OV containing targets for neuron-specific microRNA-124 and Granulocyte-macrophage colony-stimulating factor (GM-CSF), significantly enhancing its neuronal safety while minimally compromising its replication capacity. Moreover, we identified PARP1 as an HSV-1 replication restriction factor using genome-wide CRISPR screening.
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- - Messenger RNA vaccines typically don't target dendritic cells (DCs), which are crucial for presenting antigens effectively; this study focuses on a new approach to enhance DC targeting using engineered virus-like particles.
- - These engineered particles are designed to deliver mRNA that instructs cells to produce the Spike protein of SARS-CoV-2 or herpes simplex virus proteins, allowing for more effective immune responses.
- - When tested in mice, the DC-targeting mRNA vaccine produced significantly better immune responses compared to standard vaccines, providing stronger protection against both SARS-CoV-2 and herpes simplex virus 1.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the nuclear export, splicing, and sensing of RNA. However, the role of heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB) is poorly understood. In this study, we report that hnRNPAB cooperates with nucleoprotein (NP) to restrict viral mRNA nuclear export via inhibiting viral mRNA binding to ALY and NXF1.
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