Publications by authors named "Yiyang Zhang"

Non-Hodgkin's Lymphoma (NHL) remains a significant challenge in hematology, with chemotherapy and radiation therapy as conventional treatment options, albeit with limitations such as adverse effects. Immunotherapy, particularly bispecific antibodies (BsAbs) T cell engagers (TCEs), has emerged as a promising approach. Despite their potential, TCEs pose challenges, including adverse events like cytokine release syndrome.

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Soil erosion is one of the main issues that endangers global ecosystems. This study explored the spatiotemporal distribution of soil erosion and its drivers in the karst plateau mountainous region. A detailed examination of topography, soil, vegetation, land use, and precipitation data from 2000 to 2020 was conducted in Bijie City using the revised universal soil loss equation model.

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Photocatalytic colloids enable light-triggered nonequilibrium interactions and are emerging as key components for the self-assembly of colloidal molecules (CMs) out of equilibrium. However, the material choices have largely been limited to inorganic substances and the potential for reconfiguring structures through dynamic light control remains underexplored, despite light being a convenient handle for tuning nonequilibrium interactions. Here, we introduce photoresponsive N,O-containing covalent organic polymer (NOCOP) colloids, which display multi-wavelength triggered fluorescence and switchable diffusiophoretic interactions with the addition of triethanolamine.

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A 67-year-old male was admitted to our hospital with a diagnose of a <1-cm clear dehiscence orifice at the gastroesophageal anastomosis. Considering of the cachexia state and the size of fistula, a new endoscopic clipping therapy, called mucosal incision-assisted closure with clips, was performed. The procedure as follows: First, used electrotome to puncture and destroy the epithelium of the fistula mouth.

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Samples of four dead Larus vegae along the coast of Beidaihe, Qinhuangdao City, were identified by PCR amplification, multi-sequence site typing (MLST), and serum agglutination test. The drug resistance phenotype, drug resistance gene, and virulence gene were detected by the Kirby-Bauer (K-B) method and PCR method, and the pathogenicity of mice and pigeons was further tested. The phylogenetic tree was constructed by whole genome sequencing and bioinformatics analysis.

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Rechargeable batteries have been indispensable for various portable devices, electric vehicles, and energy storage stations. The operation of rechargeable batteries at low temperatures has been challenging due to increasing electrolyte viscosity and rising electrode resistance, which lead to sluggish ion transfer and large voltage hysteresis. Advanced electrolyte design and feasible electrode engineering to achieve desirable performance at low temperatures are crucial for the practical application of rechargeable batteries.

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Article Synopsis
  • Rheumatoid arthritis is a chronic autoimmune condition that involves thickening of the synovial membrane and damage to cartilage, prompting researchers to explore quercetin, a flavonoid, as a potential treatment.
  • The study utilized a collagen-induced arthritis model in rats, administering quercetin for four weeks to assess its impact on arthritis symptoms, inflammation, and underlying metabolic processes within synovial cells.
  • Results showed that quercetin significantly improved arthritis symptoms and reduced inflammation markers in rats, suggesting it may help protect against joint damage by affecting specific signaling pathways.
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Article Synopsis
  • Understanding gene regulation across different species can greatly enhance our knowledge of life and improve clinical applications, but traditional research limits itself by focusing on single organisms without cross-species integration.
  • This study created a massive dataset of over 101 million single-cell transcriptomes from humans and mice, leading to the development of an AI model called GeneCompass, which incorporates various biological knowledge to improve gene regulation understanding.
  • GeneCompass not only performed better than existing models in single-species tasks but also facilitated new research avenues across species, identifying gene factors that can influence human embryonic stem cell differentiation into specific cell types.
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Glucagon-like peptide receptor agonists (GLP-1 RAs) are associated with delayed gastric emptying and may increase the risk of aspiration due to retained gastric contents. There are no guidelines on peri-endoscopic use of GLP-1 RAs, and real-world outcomes in an ambulatory setting remain unknown. This study reports real-world data from an ambulatory center associated with a large tertiary hospital.

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The aim of this study was to investigate the effects of hypoxia-induced phenotype, glucose metabolism, ROS levels, and the PDK1-mediated regulation of TGF-β/Smad signaling in yellow cattles, yaks, and those overexpressing PDK1 PASMCs using growth curves, flow cytometry, scratch experiments, glucose and lactic acid assays, RT-qPCR, and Western blotting. The results showed that hypoxia significantly promoted proliferation, migration, antiapoptosis, ROS levels, glucose consumption, and lactate production in yellow cattle PASMCs ( < 0.05), and the cells were dedifferentiated from the contractile phenotype; conversely, hypoxia had no significant effect on yak PASMCs ( > 0.

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LiDAR point clouds can effectively depict the motion and posture of objects in three-dimensional space. Many studies accomplish the 3D object detection by voxelizing point clouds. However, in autonomous driving scenarios, the sparsity and hollowness of point clouds create some difficulties for voxel-based methods.

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The emerging all-van der Waals (vdW) magnetic heterostructure provides a new platform to control the magnetization by the electric field beyond the traditional spintronics devices. One promising strategy is using unconventional spin-orbit torque (SOT) exerted by the out-of-plane polarized spin current to enable deterministic magnetization switching and enhance the switching efficiency. However, in all-vdW heterostructures, large unconventional SOT remains elusive and the robustness of the field-free switching against external magnetic field has not been examined, which hinders further applications.

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Tomato is sweet and sour with high nutritional value, and soluble solids content (SSC) is an important indicator of tomato flavor. Due to the different mechanisms of nitrogen uptake and assimilation in plants, exogenous supply of different forms of nitrogen will have different effects on the growth, development, and physiological metabolic processes of tomato, thus affecting the tomato flavor. In this paper, hyperspectral imaging (HSI) technique combined with neural network prediction model was used to predict SSC of tomato under different nitrogen treatments.

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With the steady development of global economy and the rapid increase of population, it is of great significance to quantify the supply capacity of ecosystem services and reveal its driving factors for sustainable development. We quantify the ecosystem supply service intensity (ESSI) using multiple sources of natural and cultural data from 2000 to 2020. We then jointly analyze this data with the information entropy of the land to obtain the temporal and spatial evolution law of ESSI under multiple scales in China.

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In this paper, the changes in oil body emulsion (OBE) during heptanoic acid demulsification (HD) were investigated from the macro and microscopic points of view. Specifically, the OBE particle size increased from 3.04 to 8.

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Cold stress can impact plant biology at both the molecular and morphological levels. We cultivated two different types of tobacco seedlings using distinct seeding methods, observing significant differences in their cold tolerance at 4 °C. After 12 h cold stress, shallow water seeding cultivation treatment demonstrates a relatively good growth state with slight wilting of the leaves.

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Polyaniline-supported metal nanoparticles (M@PANIs) have been widely employed as catalysts for organic reactions. Traditionally, the catalytic activities of the materials can be improved by introducing functional groups onto the aniline monomers, but it may enhance the catalyst cost and reduce the production yield of the material. This work reports a new strategy for improving the catalytic activity of M@PANIs.

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Jiedu-Quyu-Ziyin Fang (JQZF) is a formula that has been empirically used for the treatment of SLE in clinical practice. JQZF has become an approved hospital prescription in China. Fifteen MRL/lpr mice were randomly divided into three groups: Model, JQZF, and JQZF + GC, with five mice in each group.

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Background: Digenetic trematodes, including blood flukes, intestinal flukes, liver flukes, lung flukes, and pancreatic flukes, are highly diverse and distributed widely. They affect at least 200 million people worldwide, so better understanding of their global distribution and prevalence are crucial for controlling and preventing human trematodiosis. Hence, this scoping review aims to conduct a comprehensive investigation on the spatio-temporal distribution and epidemiology of some important zoonotic digenetic trematodes.

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The present study aims to investigate the distribution and expression characteristics of HIF-1α, VEGF, VEGFR-2, VCAM-1, and IL-4 in the spleen of plateau yaks and plain yellow cattle and to speculate the possible regulatory role of HIF-1α and its related hypoxia-inducible factors in the adaptation of the yak spleen to the plateau hypoxic environment. Histological features were observed using H&E and PAS stains. Immunohistochemical staining and optical density analysis were applied to investigate the distribution and differences in the expression of HIF-1α, VEGF, VEGFR-2, VCAM-1, and IL-4 in the spleen of yaks and cattle.

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The dynamic changes in dissolved organic matter (DOM) during the transport of landfill leachate (LL) in porous medium should be explored, considering the high levels of DOM in the LL of municipal solid waste. Column experiments were carried out at 25 °C at a Darcy's flux of 0.29 cm/h for 2722 h to compare the transport of Cl, ultraviolet absorbance at 254 nm (UV), chemical oxygen demand (COD), and dissolved organic carbon (DOC) in the simulated porous medium by using the CXTFIT2.

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This study investigates specific changes in brain function during cognitive and emotional tasks in patients with schizophrenia and a history of violence (VSCZ) compared with non-violent patients with schizophrenia and healthy controls. A comprehensive literature search was conducted at the Web of Science, Medline, and PubMed. Ten studies met the inclusion criteria.

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Alterations to interstitial cells of Cajal (ICC) and collagen fibrosis have been implicated in the pathogenesis of gastroparesis. We aimed to evaluate the feasibility and safety of pyloric muscle sampling during gastric peroral endoscopic myotomy (G-POEM) and the association between pyloric ICC density and degree of fibrosis with clinical outcomes. This was a single-center prospective study of gastroparetic patients who underwent G-POEM and intraprocedural pyloric muscle biopsies between January 2022 and April 2023.

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Spatial transcriptome technologies have enabled the measurement of gene expression while maintaining spatial location information for deciphering the spatial heterogeneity of biological tissues. However, they were heavily limited by the sparse spatial resolution and low data quality. To this end, we develop a spatial location-supervised auto-encoder generator STAGE for generating high-density spatial transcriptomics (ST).

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