Publications by authors named "Yiyang Li"

As research into the mechanisms of orthopedic diseases continues to deepen, the shortcomings of traditional single-target the-rapies are becoming increasingly apparent. Consequently, the search for multi-target drugs has become the mainstream research direction for orthopedics-related diseases. Artemisinin, a sesquiterpene lactone compound extracted from Artemisia annua, has led to the gradual synthesis of various derivatives such as dihydroartemisinin, artesunate, artemether, and arteether.

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The ability to measure current and voltage is core to both fundamental study and engineering of electrochemical systems, including batteries for energy storage. Electrochemical measurements have traditionally been conducted on macroscopic electrodes on the order of 1 cm or larger. In this Perspective, we review recent developments in using microscopic electrodes (<100 μm) for the study of battery materials.

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Immunotherapy has emerged as a pioneering therapeutic modality, particularly within the realm of oncology, where Chimeric Antigen Receptor T-cell (CAR-T) therapy has manifested significant efficacy in the treatment of hematological malignancies. Nonetheless, the extension of immunotherapy to solid tumors poses a considerable challenge. This challenge is largely attributed to the intrinsic "cold" characteristics of certain tumors, which are defined by scant T-cell infiltration and a diminished immune response.

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  • * This study explored the connection between melatonin-related genes and osteoporosis using bioinformatics, identifying CSNK1D as a key gene involved in both circadian rhythm and osteoclastogenesis.
  • * Experimental results showed that CSNK1D is critical for osteoclast differentiation and inflammation, indicating it may serve as a potential therapeutic target for osteoporosis treatments that focus on circadian rhythm regulation.
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Imaging mass cytometry (IMC) permits high-dimensional single-cell spatial proteomics by harnessing mass tags to replace conventional fluorescence tags. However, the current IMC technique commonly adopts metal-chelated polymer (MCP) tags, which are limited in sensitivity, multiplicity and data acquisition speed. Here, we demonstrate nanometal-organic framework (NMOF) tags, which could concurrently augment IMC's sensitivity, multiplicity, and acquisition speed.

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Objective: Evaluation of the diagnostic accuracy of combined detection of serum homocysteine (Hcy), C-reactive protein (CRP), and serum ferritin (SF) levels in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI).

Study Design: Descriptive study. Place and Duration of the Study: Clinical Laboratory Section, Affiliated Hospital of Hebei University, Baoding, Heibei, China, from May 2022 to June 2023.

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We investigate the relaxation dynamics of crystalline stems in relation to the molecular topology of the crystalline/amorphous interface, employing coarse-grained molecular dynamics. To efficiently generate model semicrystalline systems of linear polyethylene with a realistic interphase morphology, we simplified the Monte Carlo method by introducing molecular dynamics for faster relaxation. The structural properties of the generated systems are validated against experimental measurements, theoretical predictions, and existing simulation data.

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  • Thromboembolic strokes are the most common type and pose significant health and societal challenges despite existing treatments like intravenous thrombolysis, which have limitations due to their narrow therapeutic window and inflammatory side effects.
  • This study presents a new microalgae-derived nanosystem designed to target thromboembolic strokes more effectively, leveraging a neutrophil-mimetic approach that enhances specificity and accumulation at the thrombus site.
  • The nanosystem offers multiple therapeutic benefits, including controlled release of a thrombolytic agent and the ability to boost ATP and NADPH levels, which can mitigate inflammation, oxidative stress, and neuronal injury during stroke recovery.
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Early diagnosis and treatment of colorectal polyps are crucial for preventing colorectal cancer. This paper proposes a lightweight convolutional neural network for the automatic detection and auxiliary diagnosis of colorectal polyps. Initially, a 53-layer convolutional backbone network is used, incorporating a spatial pyramid pooling module to achieve feature extraction with different receptive field sizes.

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In this study, a novel active film was developed by employing ε-polylysine (ε-PL) as a filler in pullulan/curdlan (P/CD) composite film (P/CD/ε-PL). The results showed that the structure of P/CD films was more uniform and denser compared to pullulan films, due to the good compatibility and intermolecular interaction between them. Among P/CD films, P/CD 6:1 film showed improved hydrophobicity, mechanical and barrier properties, and thermal stability, thereby selecting it for further use.

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Purpose: Radiotherapy is a critical treatment for early-stage extranodal nasal-type NK/T-cell lymphoma (ENKTL) and has yielded favorable survival outcomes. However, their postradiotherapy quality of life (QOL) has not been investigated. Here, we conducted a cross-sectional study to assess the QOL of ENKTL patients with disease-free survival after definitive radiotherapy and to identify factors associated with QOL and treatment optimization.

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  • Arterial thrombosis can lead to serious cardiovascular issues, and Berberine (BBR) has shown promise in treating these conditions but needs further research to understand how it works.
  • In a study on rats, BBR was injected to assess its effects on thrombus formation; results showed that BBR significantly reduced thrombus size and improved blood flow.
  • The study found that BBR helps manage thrombosis by regulating the expression of PKM2, which in turn affects t-PA levels, indicating BBR's potential as a treatment for arterial thromboembolic diseases.
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  • Total hip arthroplasty (THA) is a surgical procedure that relieves pain and improves joint function in patients with end-stage hip conditions, but outcomes vary based on multiple factors.
  • This research developed a predictive model using clinical data and radiomic characteristics from CT imaging to forecast postoperative joint function in patients who underwent robot-assisted THA (RA-THA), analyzing 136 patients divided into training and test sets.
  • The study found that significant predictors included preoperative pain and function scores, and the combined model demonstrated high accuracy in predicting functional outcomes three years post-surgery, indicating potential for personalized treatment plans.
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Since its advent in 2011, black titanium oxide (B-TiO) has garnered significant attention due to its exceptional optical characteristics, notably its enhanced absorption spectrum ranging from 200 to 2000 nm, in stark contrast to its unmodified counterpart. The escalating urgency to address global climate change has spurred intensified research into this material for sustainable hydrogen production through thermal, photocatalytic, electrocatalytic, or hybrid water-splitting techniques. The rapid advancements in this dynamic field necessitate a comprehensive update.

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Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke. However, the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.

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  • - The particle filter technique is crucial for real-time target detection in radar systems, but traditional methods struggle with complex dynamic scenes, leading to sample degradation and lower estimation accuracy.
  • - To address these issues, the paper presents an improved particle filter algorithm that separates particles into tracking and searching categories, enhancing target identification and diversity.
  • - Integrating density-based spatial clustering during the resampling phase boosts efficiency and accuracy, resulting in better detection probabilities, lower error rates, and improved adaptability in multi-target environments.
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Planting density is an important factor affecting plant growth and yield formation in rapeseed. However, the understanding of the mechanism underlying the impact of planting density on biomass, canopy, and ultimate seed yield remains limited. A field experiment was conducted to investigate the effect of planting density on seed yield, yield components, biomass accumulation and partitioning, and canopy structure.

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Composites of organic small molecules (OSMs) and single-walled carbon nanotubes (SWCNTs) have drawn great attention as flexible thermoelectric (TE) materials in recent years. Here, we synthesized thieno[2',3':4,5]thieno[3,2-]thieno[2,3-]thiophene (TTA) and 2,6-dibromothieno[2',3':4,5]thieno[3,2-]thieno[2,3-]thiophene (TTA-2Br) and compounded them with SWCNTs, obtaining thermoelectric TTA/SWCNT and TTA-2Br/SWCNT composites. The introduction of the electron-withdrawing Br group was found to decrease the highest molecular orbital energy level and bandgap () of TTA-2Br.

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The development of new recyclable and inexpensive electrochemically active species for water oxidation catalysis is the most crucial step for future utilization of renewables. Particularly, transition metal complexes containing internal multiple, cooperative metal centers to couple with redox catalysts in the inorganic Keggin-type polyoxometalate (POM) framework at high potential or under extreme pH conditions would be promising candidates. However, most reported Ni-containing POMs have been highly unstable towards hydrolytic decomposition, which precludes them from application as water oxidation catalysts (WOCs).

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Background: This study was aimed at investigating the dynamics of lipids and the effect of TAF on the lipid profile of patients including fatty liver disease in CHB patients.

Methods: The data of TC, LDL-c, HDL-c, TG, and TC/HDL ratio were collected at baseline, 24 weeks, 48 weeks, 72 weeks, and 96 weeks. CHB patients with fatty liver at baseline were further analyzed in a subgroup.

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Salt stress is one of the major adverse factors affecting plant growth and crop production. Rapeseed is an important oil crop, providing high-quality edible oil for human consumption. This experiment was conducted to investigate the effects of salt stress on the phenotypic traits and physiological processes of rapeseed.

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Nonfused ring electron acceptors (NFREAs) have emerged as promising materials for commercial applications in organic solar cells due to their straightforward synthesis process and cost-effectiveness. The rational design of their structural frameworks is crucial for enhancing device efficiency. In this study, we explore the use of maleimide and thiophene as key building blocks, employing cyclization engineering techniques.

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  • The text discusses the growing interest in using resistive random-access memory (RRAM) for storage and neuromorphic computing, particularly focusing on transition metal dichalcogenides (TMD) quantum dots (QDs).
  • It presents a new type of flexible RRAM made from high-quality tin disulfide (SnS) QDs created using a simple liquid phase method, highlighting its impressive performance.
  • The device features a significant on/off ratio of about 10 and a retention time exceeding 30,000 seconds, with its effective operation explained through a charge trapping/de-trapping mechanism involving the SnS QDs.
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This study compared the radiologic and clinical outcomes of a new seven-axis robotic-assisted total hip arthroplasty (THA) and conventional THA. Hundred and four patients were randomly assigned to two groups-the robotic-assisted THA group (RAS group) and the conventional THA group (CON group). The preoperative and postoperative Harris Hip score (HHS), acetabular inclination, anteversion, femoral offset, and leg length discrepancy (LLD) were compared.

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