miRNAs modulate altered expression of cytochrome P450s and nicotinic acetylcholine receptor subunits conferring both metabolic and target resistance to sulfoxaflor in Nilaparvata lugens (Stål).

Understanding the insecticide resistance mechanisms and their underlying regulatory pathways is essential for pest management. Previous findings indicated that the overexpression of P450 gene, CYP6ER1, was a key mechanism for sulfoxaflor metabolic resistance in Nilaparvata lugens. However, it remains unclear whether quantitative changes in the target nicotinic acetylcholine receptors (nAChRs) contribute to sulfoxaflor resistance and the underlying regulatory mechanisms involved.

Overexpression of NADPH-cytochrome P450 reductase is associated with sulfoxaflor resistance and neonicotinoid cross-resistance in Nilaparvata lugens (Stål).

Nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P450 reductase (CPR), a crucial electron-transfer partner of P450 systems, is required for various biological reactions catalyzed by P450 monooxygenase. Our previous study indicated that enhanced P450 enzyme detoxification and CYP6ER1 overexpression contributed to sulfoxaflor resistance in Nilaparvata lugens. However, the association between CPR, sulfoxaflor resistance, and neonicotinoid cross-resistance in N.

Dense deconvolution net: Multi path fusion and dense deconvolution for high resolution skin lesion segmentation.

Background: Dermoscopy imaging has been a routine examination approach for skin lesion diagnosis. Accurate segmentation is the first step for automatic dermoscopy image assessment.

Objective: The main challenges for skin lesion segmentation are numerous variations in viewpoint and scale of skin lesion region.

[Chromosome microarray analysis of four fetuses with abnormal karyotypes].

Objective: To carry out chromosomal microarray analysis (CMA) on four fetuses with abnormal karyotypes.

Methods: Amniotic fluid samples were obtained and subjected to routine G-banded karyotyping analysis. CMA was applied for cultured amniocytes to determine alterations of gene dosage and chromosomal breakpoints.