Deriving Polarimetry Feature Parameters to Characterize Microstructural Features in Histological Sections of Breast Tissues.

Objective: Mueller matrix polarimetry technique has been regarded as a powerful tool for probing the microstructural information of tissues. The multiplying of cells and remodeling of collagen fibers in breast carcinoma tissues have been reported to be related to patient survival and prognosis, and they give rise to observable patterns in hematoxylin and eosin (H&E) sections of typical breast tissues (TBTs) that the pathologist can label as three distinctive pathological features (DPFs)-cell nuclei, aligned collagen, and disorganized collagen. The aim of this paper is to propose a pixel-based extraction approach of polarimetry feature parameters (PFPs) using a linear discriminant analysis (LDA) classifier.

Anti-inflammatory effects of haptoglobin on LPS-stimulated macrophages: Role of HMGB1 signaling and implications in chronic wound healing.

Nonhealing wounds possess elevated numbers of pro-inflammatory M1 macrophages, which fail to transition to anti-inflammatory M2 phenotypes that promote healing. Hemoglobin (Hb) and haptoglobin (Hp) proteins, when complexed (Hb-Hp), can elicit M2-like macrophages through the heme oxygenase-1 (HO-1) pathway. Despite the fact that nonhealing wounds are chronically inflamed, previous studies have focused on non-inflammatory systems, and do not thoroughly compare the effects of complexed vs individual proteins.

Macrophage modulation by polymerized hemoglobins: Potential as a wound-healing therapy.

Chronic skin wounds are hypoxic and are stalled in a pro-inflammatory state. Hemoglobin (Hb)-based oxygen carriers have shown potential in increasing oxygen delivery to aid wound healing. Macrophages also take up Hb, thus altering their phenotype and the regulation of inflammation.