Exploring mRNA translation strategies for hypoxia adaptation across distantly related metazoans.

Adaptation to variations in oxygen concentration is a conserved mechanism in all metazoans. Extensive studies have been focused on the roles of hypoxia-inducible factors (HIFs) in response to hypoxia. However, HIF1α is not conserved in all animals, and HIF2α and HIF3α are only observed in vertebrates.

Rapid diagnosis and continuous monitoring of intracerebral hemorrhage with magnetic induction tomography based on stacked autoencoder.

Magnetic induction tomography (MIT) is a promising approach in rapid diagnosis and continuous monitoring of cerebral hemorrhage. A new algorithm for the reconstruction of intracerebral hemorrhage with MIT, including the location and volume of hemorrhage, is proposed in this study. First, 2D magnetic resonance imaging and computed tomography images of patients with cerebral hemorrhage were used for the development of simulation models.

Deep learning algorithms for brain disease detection with magnetic induction tomography.

Purpose: In order to improve the reconstruction accuracy of magnetic induction tomography (MIT) and achieve fast imaging especially in the detection of cerebral hemorrhage, artificial intelligence algorithms are proposed to improve the accuracy of MIT inverse problem.

Methods: According to the standard geometric data of human head, a three-dimensional (3D) head model containing four layer tissues is established for brain image reconstruction of MIT. Four deep learning (DL) networks, including restricted Boltzmann machine (RBM), deep belief network (DBN), stacked autoencoder (SAE), and denoising autoencoder (DAE), are used to solve the nonlinear reconstruction problem of MIT, and the reconstruction results of DL networks and back-projection algorithm are compared.

Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription () in Rats and Meridian Tropism Theory.

Objective: To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (, MWP) in rats and meridian tropism theory.

Methods: A high-performance liquid chromatography with Fourier transform-mass spectrometry (HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature.

Icariin protects SH-SY5Y cells from formaldehyde-induced injury through suppression of Tau phosphorylation.

Objective: To investigate the neuroprotective effects of icariin on formaldehyde (FA)-treated human neuroblastoma SH-SY5Y cells and the possible mechanisms involved.

Methods: SH-SY5Y cells were divided into FA treatment group, FA treatment group with icariin, and the control group. Cell viability, apoptosis, and morphological changes were determined by cell counting kit-8 (CCK 8), flow cytometry, and confocal microscopy, respectively.

[Study of effect of Humifuse Euphorbia Herb on alleviating insulin resistance in type 2 diabetic model KK-Ay mice].

[To explore the effect of Humifuse Euphorbia Herb ( HEH) on alleviating insulin resistance in type 2 diabetic KK-Ay mice. Totally 40 KK-Ay mice fed with high-fat diet were divided into four groups: the metformin group, the model group, the HEH low-dose group and the HEH high-dose group, and orally administrated with metformin hydrochloride (250 mg x kg(-1)), distilled water, humifuse euphorbia herb 1 g x kg(-1) and 2 g x kg(-1). Besides, C57BL/6J mice with ordinary feed were taken as the normal control group and orally administrated with equal distilled water.