Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2.

Background: Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory compounds plays a pivotal role in the secondary damage to sparing neural tissue and the failure of axonal regeneration and remyelination. Acid-sensing ion channel-1(ASIC1A) is widely activated following neurotrauma, including spinal cord injury (SCI).

Synthesis of nanosized 58S bioactive glass particles by a three-dimensional ordered macroporous carbon template.

Nanosized 58S bioactive glass (BG) particles were synthesized by using a three-dimensional ordered macroporous carbon template (OMC) with a pore size of 400nm. The obtained 58S BG particles possessed a diameter of 300nm, narrow size distribution and uniform spherical morphology. 58S/gelatin composites were prepared and showed much better mechanical properties than pure gelatin.

Functionalized poly(γ-Glutamic Acid) fibrous scaffolds for tissue engineering.

Poly(γ-glutamic acid) (γ-PGA) is a biocompatible, enzymatically-degradable, natural polymer with a higher resistance to hydrolysis than polyesters commonly used for tissue engineering scaffolds such as poly(L-lactide) (PLLA). Notably, γ-PGA's free carboxyl side groups allow for simple chemical functionalization, making it a versatile candidate for producing scaffolds. Here, a series of water-resistant fibrous scaffolds were engineered from ethyl (Et), propyl (Pr) and benzyl (Bn) esterifications of γ-PGA.

Template synthesis of ordered macroporous hydroxyapatite bioceramics.

Hydroxyapatite has found wide application in bone tissue engineering. Here we use a macroporous carbon template to generate highly ordered macroporous hydroxyapatite bioceramics composed of close-packed hollow spherical pores with interconnected channels. The template has advantages for the preparation of ordered materials.

Preparation and evaluation of a novel gastric mucoadhesive sustained-release acyclovir microsphere.

Objective: The objective of this study was to prepare a novel gastric mucoadhesive sustained-release acyclovir (AV)-resinate microsphere.

Methods: First, AV absorption ratio was quantified in a rat gastrointestinal (GI) tract model. AV-resinate was prepared by bath method and used as cores to prepare microspheres by an emulsion solvent diffusion technique with carbopol 934 as coating material.

Distinctive degradation behaviors of electrospun polyglycolide, poly(DL-lactide-co-glycolide), and poly(L-lactide-co-epsilon-caprolactone) nanofibers cultured with/without porcine smooth muscle cells.

Biodegradable nanofibers have become a popular candidate for tissue engineering scaffolds because of their biomimetic structure that physically resembles the extracellular matrix. For certain tissue regeneration applications, prolonged in vitro culture time for cellular reorganization and tissue remodeling may be required. Therefore, extensive understanding of cellular effects on scaffold degradation is needed.

Degradation behaviors of electrospun resorbable polyester nanofibers.

Biodegradable materials are widely used in the biomedical field because there is no postoperative surgery after implantation. Widely used synthetic biodegradable materials are polyesters, especially those used in tissue engineering. Advances in the tissue engineering field have brought much attention in terms of scaffold fabrication, such as with biodegradable polyester nanofibers.

Degradation of electrospun nanofiber scaffold by short wave length ultraviolet radiation treatment and its potential applications in tissue engineering.

Development in the field of tissue engineering has brought much attention in the fabrication and preparation of scaffold with biodegradable synthetic polymer nanofibers. Electrospun biodegradable polymeric nanofibers are increasingly being used to fabricate scaffolds for tissue engineering applications as they provide high surface area-to-volume ratio and possess high porosity. One common way to sterilize polymeric nanofiber scaffolds is 254-nm ultraviolet (UV) irradiation.

Long-term viability of coronary artery smooth muscle cells on poly(L-lactide-co-epsilon-caprolactone) nanofibrous scaffold indicates its potential for blood vessel tissue engineering.

Biodegradable polymer nanofibres have been extensively studied as cell culture scaffolds in tissue engineering. However, long-term in vitro studies of cell-nanofibre interactions were rarely reported and successful organ regeneration using tissue engineering techniques may take months (e.g.