Antibacterial Properties of PCL@45s5 Composite Biomaterial Scaffolds Based on Additive Manufacturing.

This study focuses on the development of polymer-bioglass composite bone scaffolds for the treatment of bone defects. PCL particles and 45s5 bioglass powder were employed as raw materials to fabricate PCL/45s5 composite wires with mass fractions of 5 wt%, 10 wt%, and 20 wt% via the twin-screw extrusion method. A cylindrical porous model was established using 3D modeling software, and a porous composite scaffold was constructed through the melt deposition manufacturing process.

PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis.

Background: Streptomyces lincolnensis is well known for producing the clinically important antimicrobial agent lincomycin. The synthetic and regulatory mechanisms on lincomycin biosynthesis have been deeply explored in recent years. However, the regulation involved in primary metabolism have not been fully addressed.