Publications by authors named "Yixian Huang"

Article Synopsis
  • YAP and TAZ are crucial coactivators often overactive in cancer, promoting tumor growth and resistance to treatments.
  • Niflumic acid (NA), a known inhibitor of YAP/TAZ, has poor effectiveness due to its short half-life, prompting the development of NA-based prodrug polymers to improve its bioavailability.
  • The selected NA polymer formed micellar nanocarriers that effectively targeted tumors and worked alongside receptor tyrosine kinase inhibitors (RTKIs) like Dasatinib, enhancing breast cancer therapy outcomes.
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MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3'-untranslated regions of target mRNAs, influencing various biological processes at the post-transcriptional level. Identifying miRNA transcription start sites (TSSs) and transcription factors' (TFs) regulatory roles is crucial for elucidating miRNA function and transcriptional regulation. miRStart 2.

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MicroRNAs (miRNAs) are small non-coding RNAs (18-26 nucleotides) that regulate gene expression by interacting with target mRNAs, affecting various physiological and pathological processes. miRTarBase, a database of experimentally validated miRNA-target interactions (MTIs), now features over 3 817 550 validated MTIs from 13 690 articles, significantly expanding its previous version. The updated database includes miRNA interactions with therapeutic agents, revealing roles in drug resistance and therapeutic strategies.

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Background Aims: Liver fibrosis is characterized by the progressive scarring of liver tissue. Oxidative stress is a critical causal factor of hepatic stellate cell (HSC) activation and the subsequent liver fibrogenesis, but the mechanism is not fully understood. Cysteine sulfinic acid (Cys-SO2H), a modification of reactive cysteine residues, is a unique form of oxidative response that alters the structure and function of proteins.

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Article Synopsis
  • Hepatic stellate cells (HSCs) play a crucial role in the development of liver fibrosis, and the enzyme CYP1B1 is found to be elevated in fibrotic liver tissue in both humans and mice.
  • Targeted inhibition or removal of CYP1B1 in mice reduced HSC activation and provided protection against liver fibrosis caused by various damaging substances, particularly in male mice.
  • The study highlights trehalose, a disaccharide that increases in CYP1B1-deficient HSCs, as a potential antifibrotic agent, suggesting that inhibiting CYP1B1 or using trehalose derivatives could lead to new treatments for liver fibrosis.
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Cancer is a severe illness that significantly threatens human life and health. Anticancer peptides (ACPs) represent a promising therapeutic strategy for combating cancer. In silico methods enable rapid and accurate identification of ACPs without extensive human and material resources.

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  • Drug repositioning offers a quicker and cheaper way to find new uses for existing drugs, but current databases have limitations like inadequate data and poor organization.
  • The new DrugRepoBank database includes a 'Literature' module with extensive drug repositioning studies, and a 'Prediction' module that uses various algorithms to suggest new drug candidates.
  • DrugRepoBank provides an easy-to-use web interface, allowing users to input drugs or diseases to receive new target suggestions and access related information, potentially speeding up the drug repositioning process.
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  • Enhancers are important noncoding DNA elements that regulate gene expression by interacting with transcription factors, and identifying them is crucial but resource-intensive.
  • This study introduces a new deep learning framework called CapsEnhancer, which encodes DNA sequences into unique images and uses a capsule network to analyze these images for enhancer identification.
  • CapsEnhancer outperforms previous methods by achieving accuracy rates of 94.5% and 95% in its two stages, marking a novel use of computer vision techniques in this area of biology.
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Background: Additional resection for invasive cancer at perihilar cholangiocarcinoma (pCCA) resection margins has become a consensus. However, controversy still exists regarding whether additional resection is necessary for residual biliary intraepithelial neoplasia (BilIN).

Method: Consecutive patients with pCCA from two hospitals were enrolled.

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  • Time-series experiments help us understand biological processes over time, but identifying causal mechanisms can be challenging.
  • This study introduces a new algorithm that combines known biological networks with gene expression data to map out signaling pathways during the transition from aerobic to anaerobic conditions.
  • The research identifies a novel regulatory network involving environmentally responsive genes that influence nitrogen metabolism regulators, ultimately affecting cell motility, enhancing our understanding of microbial physiology and its potential biotechnological applications.
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  • This study investigates the impact of vascular reconstruction (VR) on survival outcomes in patients with hilar cholangiocarcinoma (HCCA) who undergo radical resection surgery.* -
  • It involves a retrospective analysis of 447 patients, revealing that while VR did not significantly improve short-term survival, complications like bile leakage and postoperative infection were more frequent in the VR group.* -
  • The research identifies several independent risk factors for overall and recurrence-free survival, emphasizing that despite the lack of short-term benefits, long-term outcomes appeared worse for patients who underwent VR.*
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Article Synopsis
  • - The rise of antibiotic-resistant bacteria is a major public health issue, prompting the need for new antibacterial strategies, particularly through the use of antibacterial peptides (ABPs).
  • - AMPActiPred is a unique three-stage computational framework that identifies ABPs, evaluates their effectiveness against various bacteria, and predicts their activity levels using advanced deep learning techniques, achieving high accuracy in its predictions.
  • - This framework not only offers strong predictive capabilities but also provides clear insights into the features that contribute to ABP effectiveness and is accessible through a user-friendly web interface for researchers.
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Antiviral peptides (AVPs) have shown potential in inhibiting viral attachment, preventing viral fusion with host cells and disrupting viral replication due to their unique action mechanisms. They have now become a broad-spectrum, promising antiviral therapy. However, identifying effective AVPs is traditionally slow and costly.

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Scramblase Xk-related protein 8 (Xkr8) regulates the externalization of phosphatidylserine (PS) during apoptosis and holds a pivotal role in fostering tumor immunosuppression. Targeting Xkr8 in conjunction with chemotherapy demonstrated a novel avenue for amplifying antitumor immune response and overcoming chemo-immune resistance. Here we further evaluated this strategy by using a clinically relevant orthotopic model and elucidated the mechanism through in-depth single-cell RNA sequencing (scRNA-seq).

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Background: Potato virus Y (PVY) is a prominent representative of plant viruses. It can inflict severe damage upon Solanaceae plants, leading to global dissemination and substantial economic losses. To discover new antiviral agents, a class of planar chiral thiourea molecules through the key step of N-heterocyclic carbene-catalyzed nitrile formation reaction was synthesized with excellent optical purities for antiviral evaluations against plant virus PVY.

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Kinases as important enzymes can transfer phosphate groups from high-energy and phosphate-donating molecules to specific substrates and play essential roles in various cellular processes. Existing algorithms for kinase activity from phosphorylated proteomics data are often costly, requiring valuable samples. Moreover, methods to extract kinase activities from bulk RNA sequencing data remain undeveloped.

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(PVY) is an important plant virus that has spread worldwide, causing significant economic losses. To search for novel structures as potent antiviral agents, a series of chiral indole derivatives containing oxazoline moieties were designed and synthesized and their anti-PVY activities were evaluated. Biological activity tests demonstrated that many chiral compounds exhibited promising anti-PVY activities and that their absolute configurations exhibited obvious distinctions in antiviral bioactivities.

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PARP inhibitors (PARPi)-based synthetic lethal therapy demonstrates limited efficacy for most cancer types that are homologous recombination (HR) proficient. To potentiate the PARPi application, a nanocarrier based on 5-azacytidine (AZA)-conjugated polymer (PAZA) for the codelivery of AZA and a PARP inhibitor, BMN673 (BMN) is developed. AZA conjugation significantly decreased the nanoparticle (NP) size and increased BMN loading.

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N-Heterocyclic carbenes (NHCs) catalysts have been employed as effective tools in the development of various reactions, which have made notable contributions in developing diverse reaction modes and generating significant functionalized molecules. This review provides an overview of the recent advancements in the chemo- and regioselective activation of different aldehydes using NHCs, categorized into five parts based on the different activation modes. A brief conclusion and outlook is provided to stimulate the development of novel activation modes for accessing functional molecules.

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The multifaceted chemo-immune resistance is the principal barrier to achieving cure in cancer patients. Identifying a target that is critically involved in chemo-immune-resistance represents an attractive strategy to improve cancer treatment. iRhom1 plays a role in cancer cell proliferation and its expression is negatively correlated with immune cell infiltration.

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Background: Nonearly biliary complications (BCs) after liver transplantation (LT) are highly associated with immunological status. Tacrolimus is the main immunosuppressant. Whether and how tacrolimus bioavailability affects BCs is unclear.

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Objectives: To analyze the distribution characteristics of Traditional Chinese Medicine (TCM) syndromes in patients with oxaliplatin-induced peripheral neuropathy (OIPN) and observe the clinical efficacy of Bushen Yiqi formula (, BSYQF) in treating patients with OIPN.

Methods: A total of 89 patients with OIPN were enrolled in this study. The TCM syndrome characteristics were investigated by frequency analysis methodology after collecting and analyzing the TCM syndrome elements of the patients with the OIPN TCM syndrome element scale.

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Drug-target interactions (DTIs) are considered a crucial component of drug design and drug discovery. To date, many computational methods were developed for drug-target interactions, but they are insufficiently informative for accurately predicting DTIs due to the lack of experimentally verified negative datasets, inaccurate molecular feature representation, and ineffective DTI classifiers. Therefore, we address the limitations of randomly selecting negative DTI data from unknown drug-target pairs by establishing two experimentally validated datasets and propose a capsule network-based framework called CapBM-DTI to capture hierarchical relationships of drugs and targets, which adopts pre-trained bidirectional encoder representations from transformers (BERT) for contextual sequence feature extraction from target proteins through transfer learning and the message-passing neural network (MPNN) for the 2-D graph feature extraction of compounds to accurately and robustly identify drug-target interactions.

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Ethnopharmacological Relevance: Sophorae Flavescentis Radix (Kushen) is the primary herb component of Compound Kushen Injection (CKI), an approved clinical treatment for tumors. Despite CKI's widespread use, the underlying mechanisms of Kushen regarding microRNA-target and pathway remain unclear in non-small cell lung cancer (NSCLC).

Aim Of The Study: This study aimed to elucidate the crucial miRNAs-targets and pathways responsible for the Kushen's impact on NSCLC.

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