Publications by Yiwu Du

Publications by authors named "Yiwu Du"

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First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors.

Xiao-Li Wei Fu-Rong Liu Ji-Hong Liu Hong-Yun Zhao Yang Zhang Yi-Wu Du

Nat Commun

November 2022

Article Synopsis

PIK3CA mutations are common in solid tumors, making PI3Kα a promising target for cancer treatment.
A study tested CYH33, a selective PI3Kα inhibitor, on 51 patients with advanced solid tumors, focusing on safety, maximum tolerated dose, and preliminary efficacy.
Results showed a maximum tolerated dose of 40 mg daily, manageable side effects, and a preliminary objective response rate of 14.3% in patients with PIK3CA mutations, suggesting potential effectiveness of CYH33.

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Phenotypic characterization and prevalence of enterotoxin genes in Staphylococcus aureus isolates from outbreaks of illness in Chengdu City.

Junni Tang Cheng Tang Juan Chen Yiwu Du Xiao-nong Yang

Foodborne Pathog Dis

December 2011

Staphylococcus aureus produces a spectrum of enterotoxin that is recognized as the main reason for causing staphylococcal food poisoning. The aim of the current study was to investigate the phenotypic characteristics and enterotoxin genotypes of S. aureus isolated from food poisoning sufferers.

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The staphylococcal nuclease prevents biofilm formation in Staphylococcus aureus and other biofilm-forming bacteria.

Junni Tang Mingsong Kang Huanchun Chen Xianming Shi Rui Zhou Yiwu Du

Sci China Life Sci

September 2011

The staphylococcal nuclease, encoded by the nuc1 gene, is an important virulence factor of Staphylococcus aureus. However, the physiological role of the nuclease has not been fully characterized. The current study observed that biofilm development could be prevented in staphylococcal nuclease-producing strains of S.

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