Efficacy of omadacycline in the treatment of : a case report.

, one of the main pathogens that causes community-acquired pneumonia, can lead to , a condition characterized predominantly by severe pneumonia. This disease, caused by the bacterium , can quickly progress to critical pneumonia and is often associated with damage to multiple organs. As a result, it requires close attention in terms of clinical diagnosis and treatment.

Advances in phage-host interaction prediction: in silico method enhances the development of phage therapies.

Phages can specifically recognize and kill bacteria, which lead to important application value of bacteriophage in bacterial identification and typing, livestock aquaculture and treatment of human bacterial infection. Considering the variety of human-infected bacteria and the continuous discovery of numerous pathogenic bacteria, screening suitable therapeutic phages that are capable of infecting pathogens from massive phage databases has been a principal step in phage therapy design. Experimental methods to identify phage-host interaction (PHI) are time-consuming and expensive; high-throughput computational method to predict PHI is therefore a potential substitute.

The Burgeoning Significance of Liquid-Liquid Phase Separation in the Pathogenesis and Therapeutics of Cancers.

Liquid-liquid phase separation (LLPS) is a physiological phenomenon that parallels the mixing of oil and water, giving rise to compartments with diverse physical properties. Biomolecular condensates, arising from LLPS, serve as critical regulators of gene expression and control, with a particular significance in the context of malignant tumors. Recent investigations have unveiled the intimate connection between LLPS and cancer, a nexus that profoundly impacts various facets of cancer progression, including DNA repair, transcriptional regulation, oncogene expression, and the formation of critical membraneless organelles within the cancer microenvironment.

Equilibrative nucleotide transporter ENT3 (SLC29A3): A unique transporter for inherited disorders and cancers.

As a crucial gene associated with diseases, the SLC29A3 gene encodes the equilibrative nucleoside transporter 3 (ENT3). ENT3 plays an essential regulatory role in transporting intracellular hydrophilic nucleosides, nucleotides, hydrophilic anticancer and antiviral nucleoside drugs, energy metabolism, subcellular localization, protein stability, and signal transduction. The mutation and inactivation of SLC29A3 are intimately linked to the occurrence, development, and prognosis of various human tumors.

Strip SAR image simulation of a composite vehicle-ground model.

In this paper, the strip synthetic aperture radar (SAR) image of a composite vehicle-ground model is simulated by combining the electromagnetic scattering algorithm and radar imaging algorithm. A linear frequency modulated wave is incident on the composite model, which is partitioned into a mass of triangular patches. In the "stop-and-go" radar mode, for each patch, the amplitude of scattered echo in the frequency domain is solved by a hybrid method of physical optics (PO)-shooting and bouncing ray (SBR)-physical theory of diffraction (PTD).

Erratum: Eightfold Degenerate Fermions in Two Dimensions [Phys. Rev. Lett. 127, 176401 (2021)].

This corrects the article DOI: 10.1103/PhysRevLett.127.

Eightfold Degenerate Fermions in Two Dimensions.

Multifold degenerate fermions have attracted a lot of research interest in condensed matter physics and materials science, but always lack in two dimensions. In this Letter, from symmetry analysis and lattice model construction, we demonstrate that eightfold degenerate fermions can be realized in two-dimensional systems. In nonmagnetic materials with negligible spin-orbit coupling, the gray magnetic space groups together with SU(2) spin rotation symmetry can protect the two-dimensional eightfold degenerate fermions on a certain high-symmetry axis in the Brillouin zone, no matter whether the system is centrosymmetric or noncentrosymmetric.

Modeling Cardinality in Image Hashing.

Cardinality constraint, namely, constraining the number of nonzero outputs of models, has been widely used in structural learning. It can be used for modeling the dependencies between multidimensional labels. In hashing, the final outputs are also binary codes, which are similar to multidimensional labels.

Interval Type-2 Fuzzy Logic for Semisupervised Multimodal Hashing.

Retrieving nearest neighbors across correlated data in multiple modalities, such as image-text pairs on Facebook and video-tag pairs on YouTube, has become a challenging task due to the huge amount of data. Multimodal hashing methods that embed data into binary codes can boost the retrieving speed and reduce storage requirements. Since unsupervised multimodal hashing methods are usually inferior to supervised ones and the supervised ones require too much manually labeled data, the proposed method in this paper utilizes partially available labels to design a semisupervised multimodal hashing method.

Improving the Topside Profile of Ionosonde with TEC Retrieved from Spaceborne Polarimetric SAR.

Signals from spaceborne polarimetric synthetic aperture radar will suffer from Faraday rotations when they propagate through the ionosphere, especially those at L-band or lower frequencies, such as signals from the Phased Array type L-band Synthetic Aperture Radar (PALSAR). For this reason, Faraday rotation compensation should be considered. On the other hand, Faraday rotation could also be retrieved from distorted echoes.

Modulation of resting-state brain functional connectivity by exposure to acute fourth-generation long-term evolution electromagnetic field: An fMRI study.

By now, the neurophysiological effect of electromagnetic field (EMF) exposure and its underlying regulating mechanisms are not well manifested. In this study, we aimed to investigate whether acute long-term evolution (LTE) EMF exposure could modulate brain functional connectivity using regional homogeneity (ReHo) method and seed-based analysis on resting-state functional magnetic resonance imaging (fMRI). We performed the LTE-EMF exposure experiment and acquired the resting-state brain activities before and after EMF exposure.