Simple and sensitive monitoring of polycyclic aromatic hydrocarbons in edible oils by polydimethylsiloxane/pyrazine-based hyper-crosslinked polymer coated stir bar sorptive extraction followed by gas chromatography-mass spectrometry detection.

Background: Edible oils are susceptible to contamination with polycyclic aromatic hydrocarbons (PAHs) throughout production, storage, and transportation processes due to their lipophilic nature. The necessity of quantifying PAHs present in complex oil matrices at trace levels, which bind strongly to impurities in oil matrices, poses a major challenge to the accurate quantification of these contaminants. Therefore, the development of straightforward and effective methods for the separation and enrichment of PAHs in oil samples prior to instrumental analysis is paramount to guaranteeing food safety.

Interaction-Enhanced Superradiance of a Rydberg-Atom Array.

We study the superradiant phase transition of an array of Rydberg atoms in a dissipative microwave cavity. Under the interplay of the cavity field and the long-range Rydberg interaction, the steady state of the system exhibits an interaction-enhanced superradiance, with vanishing critical atom-cavity coupling rates at a discrete set of interaction strengths. We find that, while the phenomenon can be analytically understood in the case of a constant all-to-all interaction, the enhanced superradiance persists under typical experimental parameters with spatially dependent interactions, but at modified critical interaction strengths.

Inhibition of ZFP281/ZNF281-RIPK1/RIPK3/MLKL signaling in hepatocytes by pterostilbene relieves hepatic lipometabolic disorder and inflammation in non-alcoholic steatohepatitis.

Non-alcoholic steatohepatitis (NASH) is the most common cause of chronic liver diseases with its pathophysiological mechanism poorly understood. In this work, serological, histological, molecular biological, biochemical, and immunological methods were applied to explore the pathological significance and action of zinc finger protein 281 (ZFP281 in mouse, ZNF281 in human) and targeted strategies. We reported that ZFP281/ZNF281 abundance in hepatocytes was positively correlated with the progression of NASH.

Exploring the Updated Roles of Ferroptosis in Liver Diseases: Mechanisms, Regulators, and Therapeutic Implications.

Ferroptosis, a newly discovered mode of cell death, is a type of iron-dependent regulated cell death characterized by intracellular excessive lipid peroxidation and imbalanced redox. As the liver is susceptible to oxidative damage and the abnormal iron accumulation is a major feature of most liver diseases, studies on ferroptosis in the field of liver diseases are of great interest. Studies show that targeting the key regulators of ferroptosis can effectively alleviate or even reverse the deterioration process of liver diseases.

Green preparation of magnetic pyrene-based hyper-cross-linked polymer using dual-purpose ferric chloride reagent for extraction of polycyclic aromatic hydrocarbons from natural water bodies.

A magnetic hyper-cross-linked polymer FeO/HCP was prepared using pyrene as the monomer and formaldehyde dimethyl acetal (FDA) as the cross-linking agent. The objective of green chemistry was achieved by employing FeCl during the synthesis, as it played a dual role of a catalyst for the Friedel-Crafts reaction and an iron source for the synthesis of magnetic FeO, thus maximizing efficiency and minimizing waste. FeO/HCP was applied as a sorbent for magnetic solid-phase extraction (MSPE) to extract fifteen polycyclic aromatic hydrocarbons (PAHs) from water.

Monocytes as an early risk factor for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

Acute graft-versus-host disease (aGVHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and contributes to high morbidity and mortality. However, our current understanding of the development and progression of aGVHD after allo-HSCT remains limited. To identify the potential biomarkers for the prevention and treatment of aGVHD during the early hematopoietic reconstruction after transplantation, we meticulously performed a comparative analysis of single-cell RNA sequencing data from post-transplant patients with or without aGVHD.

Improving hydrological modeling to close the gap between elevated CO concentration and crop response: Implications for water resources.

Rising atmospheric carbon dioxide concentrations ([CO]) affect crop growth and the associated hydrological cycle through physiological forcing, which is mainly regulated by reducing stomatal conductance (g) and increasing leaf area index (LAI). However, reduced g and increased LAI can affect crop water consumption, and the overall effects need to be quantified under elevated [CO]. Here we develop a SWAT-g-LAI model by incorporating a nonlinear g-CO equation and a missing LAI-CO relationship to investigate the responses of water consumption of grain maize, maize yield, and losses of water and soil to elevated [CO] in the Upper Mississippi River Basin (UMRB; 492,000 km).

Response of hydrology and nutrient losses to different extreme rainfall conditions in a coastal watershed influenced by orchards.

Global warming is altering the frequency of extreme rainfall events and introducing uncertainties for non-point source pollution (NPSP). This research centers on orchard-influenced planting areas (OIPA) in the Wulong River Watershed of Shandong Province, China, which are known for their heightened nitrogen (N) and phosphorus (P) pollution. Leveraging meteorological data from both historical (1989-2018) and projected future periods (2041-2100), this research identified five extreme rainfall indices (ERI): R10 (moderate rain), R20 (heavy rain), R50 (rainstorm), R95p (Daily rainfall between the 95th and 99th percentile of the rainfall), and R99p (>99th percentile).

Formononetin attenuates hepatic injury in diabetic mice by regulating macrophage polarization through the PTP1B/STAT6 axis.

Background: Formononetin (FNT) is an isoflavone known for its anti-inflammatory properties and has been shown to reduce insulin resistance in Type 2 Diabetes Mellitus (T2DM). However, its effects and the underlying mechanisms in diabetic liver injury remain largely unexplored.

Methods: We established a T2DM-induced liver injury mouse model by feeding high-fat diet, followed by injecting streptozotocin.

The response of non-point source pollution to climate change in an orchard-dominant coastal watershed.

China is the largest global orchard distribution area, where high fertilization rates, complex terrain, and uncertainties associated with future climate change present challenges in managing non-point source pollution (NPSP) in orchard-dominant growing areas (ODGA). Given the complex processes of climate, hydrology, and soil nutrient loss, this study utilized an enhanced Soil and Water Assessment Tool model (SWAT-CO) to investigate the impact of future climate on NPSP in ODGA in a coastal basin of North China. Our investigation focused on climate-induced variations in hydrology, nitrogen (N), and phosphorus (P) losses in soil, considering three Coupled Model Intercomparison Project phase 6 (CMIP6) climate scenarios: SSP1-2.

Doing housework and having regular daily routine standing out as factors associate with physical function in the older people.

Background And Objectives: Nationwide data were used to explore factors associated with physical function in order to identify interventions that could improve and maintain physical function in the older people.

Methods: The physical function was assessed by gait speed (GS). We selected 2,677 male and 2,668 female older adults (aged ≥60) who could perform the GS test as study subjects.

Age-related change in muscle strength, muscle mass, and fat mass between the dominant and non-dominant upper limbs.

Background: Any form of physical activity is recommended for the older adults to maintain their physical function; however, the effect of daily activities on muscle function still needs to be investigated. Humans always use one dominant hand to perform tasks, providing a natural situation for research on the effect of daily activities on muscle function.

Methods: Five hundred and twenty-six healthy adults were recruited from the community in Beijing.

Changes in circMyt1l/rno-let-7d-5p/brain-derived neurotrophic factor. A damaged periventricular white matter damage model in neonatal rats.

Objectives: To investigate the function of circMyt1l/rno-let-7d-5p/BDNF in the white matter damage of premature rats.

Methods: Bioinformatic analysis was used to analyze the differential expression of circMyt1l and its interacting miRNAs and mRNAs in rats with periventricular white matter damage. Rats at postnatal day 3 had their right common carotid artery permanently ligated, and were then exposed for 2 h to 6 % O, or sham surgery and exposure to normal O levels (sham).

Highly efficient sulfur-doped NiFe electrocatalysts for overall water splitting: Rapid synthesis, mechanism and driven by sustainable energy.

Designing efficient electrocatalysts and insight into their electrocatalytic mechanisms are significantly important for storing and converting the intermittent sustainable energy sources into clean hydrogen. In this study, we synthesize the bifunctional sulfur-doped NiFe (NiFeS) electrocatalysts by a simple electrodeposition method only taking 30 s. After optimizing the components, it was found that the synthesized NiFeS electrocatalysts exhibit the excellent hydrogen and oxygen evolution reaction performances in 1.

Surface-Controlled CdS/Ti C MXene Schottky Junction for Highly Selective and Active Photocatalytic Dehydrogenation-Reductive Amination.

Photocatalytic valorization and selective transformation of biomass-derived platform compounds offer great opportunities for efficient utilization of renewable resources under mild conditions. Here, the novel three-dimensional hierarchical flower-like CdS/Ti C Schottky junction (MCdS) composed of surface-controlled CdS and pretreated Ti C MXene is created for photocatalytic dehydrogenation-reductive amination of biomass-derived amino acid production under ambient temperature with unprecedented activity and selectivity. Schottky junction efficiently promotes photoexcited charge migration and separation and inhibits photogenerated electron-hole recombination, which results in a super-high activity.

Detecting Non-Bloch Topological Invariants in Quantum Dynamics.

Non-Bloch topological invariants preserve the bulk-boundary correspondence in non-Hermitian topological systems, and are a key concept in the contemporary study of non-Hermitian topology. Here we report the dynamic detection of non-Bloch topological invariants in single-photon quantum walks, revealed through the biorthogonal chiral displacement, and crosschecked with the dynamic spin textures in the generalized quasimomentum-time domain following a quantum quench. Both detection schemes are robust against symmetry-preserving disorders, and yield consistent results with theoretical predictions.

TPL Inhibits the Invasion and Migration of Drug-Resistant Ovarian Cancer by Targeting the PI3K/AKT/NF-κB-Signaling Pathway to Inhibit the Polarization of M2 TAMs.

Chemoresistance is the primary reason for the poor prognosis of patients with ovarian cancer, and the search for a novel drug treatment or adjuvant chemotherapy drug is an urgent need. The tumor microenvironment plays key role in the incidence and development of tumors. As one of the most important components of the tumor microenvironment, M2 tumor-associated macrophages are closely related to tumor migration, invasion, immunosuppressive phenotype and drug resistance.

Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions.

Vaginal microbiota dysbiosis, characterized by the loss of dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.

Measuring and Quantifying Impacts of Environmental Parameters on Airborne Particulate Matter in Under-Viaducts Spaces in Wuhan, China.

Particulate pollution caused by urban traffic emissions has become a significant public hazard. Many urban roads of under-viaduct spaces (UVSs) have become concentrated areas of particulate pollution. This study aims to explore the effects of landscape parameters on particulate matter in UVSs in Wuhan, China.

Differential microRNAs expression profiles in liver from three different lifestyle modification mice models.

Background: MicroRNAs play an important role in many fundamental biological and pathological processes. Defining the microRNAs profile underlying the processes by beneficial and detrimental lifestyles, including caloric restriction (CR), exercise and high-fat diet (HF), is necessary for understanding both normal physiology and the pathogenesis of metabolic disease. We used the microarray to detect microRNAs expression in livers from CR, EX and HF mice models.

Dysbiosis of the rat vagina is efficiently rescued by vaginal microbiota transplantation or probiotic combination.

Vaginal dysbiosis is characterised by a disturbed vaginal microbiota and is associated with various gynaecological diseases. Owing to its high recurrence rate, there is an urgent need for the development of effective therapeutic agents. In the present study, a vaginal dysbiosis model was developed to study the effect of vaginal microbiota transplantation (VMT) or probiotic combination (containing Lactobacillus helveticus, Lactobacillus crispatus, Lactobacillus acidophilus, Lactobacillus gasseri and Lactobacillus salivarius) on vaginal dysbiosis.

Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.

Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative diseases (NDD) characterized by progressive degeneration of the central nervous system, and few medications are available to halt the progression of AD and PD. In the present study, an engineered strain MG136-pMG36e-GLP-1 was used to evaluate its neuroprotective effect on AD and PD mice, via the probiotics effects of Lactococcus lactis MG1363 and the constantly produced Glucagon-like peptide-1 (GLP-1) by the engineered strain. Our results indicated that oral administration of MG136-pMG36e-GLP-1 significantly reduced lipopolysaccharide (LPS)-induced memory impairment and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction through the toll-like receptor4 (TLR4)/nuclear factor-kappa B (NFκB) and protein kinase B (AKT)/Glycogen synthase kinase-3β (GSK3β) signaling pathway.

Oral Probiotics Alleviate Intestinal Dysbacteriosis for People Receiving Bowel Preparation.

Bowel preparation is necessary for successful colonoscopy, while it can seriously affect intestinal microbial composition and damage the intestinal mucosal barriers in humans. To figure out whether probiotics can sustain intestinal homeostasis and guard people's health, the probiotic drug of Tetragenous viable Bacteria Tablets (P group, = 16) or placebo (C group, = 16) was used for volunteers receiving bowel preparation, and high-throughput sequencing method was applied to monitor their intestinal microbial changes. The present results suggested that bowel preparation obviously reduced the intestinal microbial diversity, while taking probiotics significantly restored it to normal level.

Characteristics of decline in cognition and locomotion among the elderly in seven provinces of China.

Background: Decline in cognition and in locomotion is associated with aging. However, the relationship between them and the current occurrence of them in Chinese elderly people was weak.

Methods: To investigate the details of these two functions in Chinese elderly people and to try to find some early recognition and intervention clues, data of MMSE test and usual gait speed from 4487 elderly people from seven provinces in China were analysed.