An analysis of spatial changes in the manufacturing industry in china's three major urban clusters from 2015 to 2019 using POI data.

China's manufacturing industry has been ranked as the most valuable in the world from 2010 to 2021. However, high-resolution manufacturing datasets are lacking, and this has precluded study of the survival rates and spatial changes in the manufacturing industry in China. Here, we analyzed spatial patterns of the manufacturing industry using point-of-interest (POI) data and a machine learning classification algorithm based on the Naive Bayes classifier.

Gut Microbiota-Butyrate-PPARγ Axis Modulates Adipose Regulatory T Cell Population.

Gut microbiota is essential for the function of peripherally-induced regulatory T (pTreg) cells. However, how commensal bacteria affect thymically derived fat-resident Treg cells that harbor a unique expression of peroxisome proliferator-activated receptor (PPAR)-γ and suppress inflammation in visceral adipose tissue (VAT), is not well defined. Here it is revealed that microbiota depletion causes a drastic decline in Treg cell population in VAT, particularly those expressing ST2 (ST2 Treg), which are largely restored after gut microbiome reconstruction.

Joint suppression of cardiac bSSFP cine banding and flow artifacts using twofold phase-cycling and a dual-encoder neural network.

Background: Cardiac balanced steady state free precession (bSSFP) cine imaging suffers from banding and flow artifacts induced by off-resonance. The work aimed to develop a twofold phase cycling sequence with a neural network-based reconstruction (2P-SSFP+Network) for a joint suppression of banding and flow artifacts in cardiac cine imaging.

Methods: A dual-encoder neural network was trained on 1620 pairs of phase-cycled left ventricular (LV) cine images collected from 18 healthy subjects.

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels.

Peptide hydrogels are highly hydrophilic, three-dimensional network gels formed by the self-assembly of nanofibers or polymers, creating water-locking networks. Their morphology closely resembles that of the extracellular matrix, allowing them to exhibit both the biological functions of peptides and responsive gelation properties. These unique characteristics have led to their extensive application in tissue engineering, three-dimensional cell culture, cancer therapy, regenerative medicine, and other biomedical fields.

Free-breathing non-contrast T1ρ dispersion magnetic resonance imaging of myocardial interstitial fibrosis in comparison with extracellular volume fraction.

Background: Myocardial fibrosis is a common feature in various cardiac diseases. It causes adverse cardiac remodeling and is associated with poor clinical outcomes. Late gadolinium enhancement (LGE) and extracellular volume fraction (ECV) are the standard magnetic resonance imaging techniques for detecting focal and diffuse myocardial fibrosis.

High Spatial-Resolution and Acquisition-Efficiency Cardiac MR T1 Mapping Based on Radial bSSFP and a Low-Rank Tensor Constraint.

Background: Cardiac T1 mapping is valuable for evaluating myocardial fibrosis, yet its resolution and acquisition efficiency are limited, potentially obscuring visualization of small pathologies.

Purpose: To develop a technique for high-resolution cardiac T1 mapping with a less-than-100-millisecond acquisition window based on radial MOdified Look-Locker Inversion recovery (MOLLI) and a calibrationless space-contrast-coil locally low-rank tensor (SCC-LLRT) constrained reconstruction.

Study Type: Prospective.

A dual-stage partially interpretable neural network for joint suppression of bSSFP banding and flow artifacts in non-phase-cycled cine imaging.

Purpose: To develop a partially interpretable neural network for joint suppression of banding and flow artifacts in non-phase-cycled bSSFP cine imaging.

Methods: A dual-stage neural network consisting of a voxel-identification (VI) sub-network and artifact-suppression (AS) sub-network is proposed. The VI sub-network provides identification of artifacts, which guides artifact suppression and improves interpretability.

LABA/LAMA versus LABA/ICS fixed-dose combinations in the prevention of COPD exacerbations: a modeling analysis of literature aggregate data.

Objectives: This study aimed to quantitatively compare the efficacy and safety of long-acting β-agonist (LABA)/long-acting muscarinic antagonist (LAMA) and LABA/inhaled corticosteroid (ICS) fixed-dose combinations (FDCs) in preventing moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations.

Methods: A literature search was performed using public databases. The time course characteristics of the probability of a moderate or severe exacerbation in stable COPD patients treated with LABA/LAMA and LABA/ICS FDCs were described by the parametric survival function.

Interleukin-6 and granulocyte colony-stimulating factor as predictors of the prognosis of influenza-associated pneumonia.

Background: Pneumonia is a common complication of influenza and closely related to mortality in influenza patients. The present study examines cytokines as predictors of the prognosis of influenza-associated pneumonia.

Methods: This study included 101 inpatients with influenza (64 pneumonia and 37 non-pneumonia patients).

Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD.

Objective: This study aimed to quantitatively compare the efficacy and safety of long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations (FDCs) for the treatment of stable chronic obstructive pulmonary disease (COPD), especially in terms of their loss of efficacy in lung function.

Methods: Randomized controlled clinical trials of LABA/LAMA FDCs for the treatment of stable COPD were comprehensively searched for in public databases. Pharmacodynamic models were established to describe the time course of the primary outcome [trough forced expiratory volume in the first second (FEV)].

Regulatory long non-coding RNAs of hepatic stellate cells in liver fibrosis (Review).

Liver fibrosis (LF) is a continuous wound healing process caused by numerous chronic hepatic diseases and poses a major threat to human health. Activation of hepatic stellate cells (HSCs) is a critical event in the development of hepatic fibrosis. Long non-coding RNAs (lncRNAs) that are involved in HSC activation, participate in the development of LF and are likely to be therapeutic targets for LF.

Clinical Significance of the Correlation between Changes in the Major Intestinal Bacteria Species and COVID-19 Severity.

Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease. Similar to H7N9 infection, pneumonia and cytokine storm are typical clinical manifestations of COVID-19. Our previous studies found that H7N9 patients had intestinal dysbiosis.

Effect of the Short-Term Use of Fluoroquinolone and β-Lactam Antibiotics on Mouse Gut Microbiota.

Background: Antibiotics play an important role in the treatment of infectious diseases. However, the overuse of antibiotics increases the spread of drug-resistant bacteria and causes dysbiosis of the intestinal microbiota. Few studies have addressed the longitudinal effects of antibiotics on the microbiome and host immunity.

Applicability of Equilibrium Sampling in Informing Tissue Residues and Dietary Risks of Legacy and Current-Use Organic Chemicals in Aquaculture.

Equilibrium sampling based on silicone polydimethylsiloxane (PDMS) has been used to determine the concentrations of freely dissolved hydrophobic organic compounds (HOCs) and assess the thermodynamic potentials for bioaccumulation of these compounds in the aquatic environment. This allows the use of PDMS-based sampling techniques in assisting conventional sampling and extraction methods for the determination of the concentrations of HOCs in aquaculture products. The present study is an ex situ demonstration of how well PDMS can inform the tissue residues and dietary risks of legacy or current-use organic chemicals in aquaculture species from farm ponds in eastern China.

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza.

Background: Coronavirus disease 2019 (COVID-19) is an emerging serious global health problem. Gastrointestinal symptoms are common in COVID-19 patients, and severe acute respiratory syndrome coronavirus 2 RNA has been detected in stool specimens. However, the relationship between the gut microbiome and disease remains to be established.

A hierarchically assembled 88-nuclei silver-thiacalix[4]arene nanocluster.

Thiacalix[4]arenes as a family of promising ligands have been widely used to construct polynuclear metal clusters, but scarcely employed in silver nanoclusters. Herein, an anion-templated Ag nanocluster (SD/Ag88a) built from p-tert-butylthiacalix[4]arene (HTC4A) is reported. Single-crystal X-ray diffraction reveals that C-symmetric SD/Ag88a resembles a metal-organic super calix comprised of eight TC4A as walls and 88 silver atoms as base, which can be deconstructed to eight [CrO@Ag(TC4A)(EtS)(OAc)] secondary building units arranged in an annulus encircling a CrO in the center.

Correlation Between Serum Entecavir Concentration and Virological Response in Patients with Chronic Type B Hepatitis.

BACKGROUND This study was conducted to investigate the relationship between trough concentrations of serum entecavir and the virological response of patients with chronic type B hepatitis (CHB). MATERIAL AND METHODS A total of 59 CHB patients who had been receiving antiviral therapy with entecavir for >3 months were included in this study. Serum entecavir concentrations, HBV DNA levels, and other biochemical indicators were determined after drug treatments.

Comparative transcriptome analysis reveals expression signatures of albino Russian sturgeon, Acipenseriformes gueldenstaedtii.

Albinism is a genetically inherited condition that is caused by a series of genetic abnormalities leading to a reduction in melanin production. Russian sturgeon is one of the most valuable freshwater fish species worldwide, and albino individuals have been found in fish farms. Due to its complicated genome and scarce genome-wide genetic resources, the underlying molecular basis of albinism in Russian sturgeon is unknown.

Genome-wide characterization of Toll-like receptor gene family in common carp (Cyprinus carpio) and their involvement in host immune response to Aeromonas hydrophila infection.

The Toll-like receptor (TLR) gene family is a class of conserved pattern recognition receptors, which play an essential role in innate immunity providing efficient defense against invading microbial pathogens. Although TLRs have been extensively characterized in both invertebrates and vertebrates, a comprehensive analysis of TLRs in common carp is lacking. In the present study, we have conducted the first genome-wide systematic analysis of common carp (Cyprinus carpio) TLR genes.

An ultra-high density linkage map and QTL mapping for sex and growth-related traits of common carp (Cyprinus carpio).

High density genetic linkage maps are essential for QTL fine mapping, comparative genomics and high quality genome sequence assembly. In this study, we constructed a high-density and high-resolution genetic linkage map with 28,194 SNP markers on 14,146 distinct loci for common carp based on high-throughput genotyping with the carp 250 K single nucleotide polymorphism (SNP) array in a mapping family. The genetic length of the consensus map was 10,595.

Spatial distribution and temporal trends of mercury and arsenic in remote timberline coniferous forests, eastern of the Tibet Plateau, China.

An intensive investigation was conducted to study the spatial distribution and temporal variety trend of mercury and arsenic in plant tissue and soil profile in the eastern of the Tibet Plateau and to explore the possible sources of these two elements. At present, rare information is available on mercury (Hg) and arsenic (As) of timberline forests in the Tibet Plateau. Here, we present preliminary results on these two elements in leaves, twigs, root, litterfall, and soil.

Safety analysis of tooth extraction in elderly patients with cardiovascular diseases.

Background: This study aimed to evaluate the safety of tooth extraction in elderly patients with cardiovascular diseases.

Material And Methods: A total of 13 527 patients underwent tooth extraction at the Affiliated Ninth People's Hospital of Shanghai Jiaotong University. Age, sex, and diseases were analyzed.