Hypertension phenotypes and adverse pregnancy outcome-related office and ambulatory blood pressure thresholds during pregnancy: a retrospective cohort study.

Blood pressure (BP) phenotypes, as determined by the consistency between office BP (OBP) and ambulatory BP (ABP) measurements, enhance risk assessment during pregnancy. However, diagnostic criteria for hypertension in pregnancy are based on data from non-pregnant populations regarding long-term cardiovascular risks. This study aimed to identify adverse pregnancy outcomes (APOs; including maternal/fetal outcomes)-related BP thresholds to refine risk assessment in pregnant women.

Intestinal homeostasis in the gut-lung-kidney axis: a prospective therapeutic target in immune-related chronic kidney diseases.

In recent years, the role of intestinal homeostasis in health has received increasing interest, significantly improving our understanding of the complex pathophysiological interactions of the gut with other organs. Microbiota dysbiosis, impaired intestinal barrier, and aberrant intestinal immunity appear to contribute to the pathogenesis of immune-related chronic kidney diseases (CKD). Meanwhile, the relationship between the pathological changes in the respiratory tract (e.

Photochemical reduction of CO into CO coupling with triethanolamine decomposition.

In this work, the impacts of triethanolamine (TEOA) on the performance of photochemical CO reduction were investigated in a simple homogeneous system. We demonstrates that CO can be converted into CO coupling with the decomposition of triethanolamine in TEOA aqueous solution without other additives under light irradiation. About 7.

Amide-decorated carbon dots as sensitive and selective probes for fluorescence enhancement detection of cadmium ion.

As highly toxic metal ions, cadmium ions (Cd) are prevalent in varying concentrations around the world. The establishment of an accurate and effective method for Cd determination with high sensitivity and selectivity is of particular concern. The present work fabricated a fluorescence chemosensor for the detection of Cd based on functionalized carbon dots (CDs), which were hydrothermally prepared using amidated hyperbranched-polyethyleneimine (HPEI).

GPR18 and GPR55-related Ligands Serving as Antagonists or Agonists: Current Situation, Challenges and Perspectives.

GPCR superfamily, the largest known family of membrane receptors, consists of six classes from A to F. GPR18 and GPR55, δ-branch of A class, had been reported to have no confirmed endogenous ligand and were named as "orphan receptors". Previous studies suggest that both GPR18 and GPR55 are possibly related to the migration and proliferation of cancer cells, macrophages and other inflammation-associated immune cells.

A western United States snow reanalysis dataset over the Landsat era from water years 1985 to 2021.

Water stored in mountain snowpacks (i.e., snow water equivalent, SWE) represents an important but poorly characterized component of the terrestrial water cycle.

Janus (Mo/-MoC)@C heterostructure as an efficient electrocatalyst for the hydrogen evolution reaction in acidic and alkaline media.

To explore low-cost, high-efficiency, and noble-metal-free catalysts for electrocatalytic water splitting in both acidic and alkaline media, the metal-metal carbide Janus hierarchical structure comprising Mo and-MoC embedded on a carbon layer (Mo/-MoC)@C is synthesized by a hydrothermal reaction and subsequent low-temperature magnesium thermic process. Systematic characterization by XRD, XPS, Raman scattering, and SEM/TEM reveals the successful formation of metallic Mo and-MoC nanoparticles. The synthesized (Mo/-MoC)@C has a large specific surface area and boasts highly efficient hydrogen evolution reaction activity including low overpotentials of 152 and 171 mV at a current density of 10 mA cmand small Tafel slopes of 51.

Therapeutic potential of demethylzeylasteral, a triterpenoid of the genus Tripterygium wilfordii.

Pentacyclic triterpenoids are important natural products widely presenting in nature with rich bioactivities. Tripterygium wilfordii Hook. f.

Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential.

Coumarins is a huge family of phenolic compounds containing a common structure of 2H-1-benzopyran-2-one. Nowadays, more than 1,300 natural-based coumarins have been identified in a variety of plants, bacteria and fungi, many of them exhibited promising biomedical performance. Daphnetin (7,8-dihydroxycoumarin), a typical coumarin, showed a couple of bioactivities such as anti-cancer, antibacterial, anti-inflammatory and anti-arthritis.

Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism.

Compound (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi FG216 and fungi IFO 30018, possessed diverse bioactivities such as thrombolysis, anti-inflammatory and anti-oxidative properties, and so on. It may be widely used for the treatment of various diseases, including cerebral infarction, stroke, ischemia/reperfusion damage, acute kidney injury, etc. Especially in cerebral infarction, compound could reduce hemorrhagic transformation along with thrombolytic therapy, as the traditional therapies are accompanied with bleeding risks.

Lewis base sites of non-oxide supports boost oxygen absorption and activation over supported Pt catalysts.

Formaldehyde (HCHO) oxidation to improve indoor air quality has attracted extensive attention. Designing efficient catalysts for HCHO removal at room temperature still remains challenging. Herein, we report a novel strategy to boost HCHO oxidation by the synergistic effect of Pt nanoparticles and CN.

Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA Antibody in IgA Nephropathy Patients.

Background: Galactose-deficient IgA (Gd-IgA) and alternative complement pathway activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN). Nevertheless, the relationships between alternative pathway activation and disease activity or Gd-IgA level remains unclear.

Methods: Ninety-eight biopsy-diagnosed IgAN, twenty-five primary focal segmental sclerosis (FSGS) patients and forty-two healthy individuals were recruited in this study.

Risk of nephrogenic systemic fibrosis in patients with impaired renal function undergoing fixed-dose gadoxetic acid-enhanced magnetic resonance imaging.

Purpose: To assess the risk of nephrogenic systemic fibrosis (NSF) in patients with renal impairment undergoing gadoxetic acid-enhanced magnetic resonance imaging.

Methods: This retrospective study included patients who had an estimated glomerular filtration rate (eGFR) below 60 mL/min per 1.73 m or had undergone dialysis around the time of gadoxetic acid exposure from January 2010 to November 2019.

Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019.

Marine organism-associated actinobacteria represent a valuable resource for marine drugs due to their abundant secondary metabolites. The special environments in the ocean, for instance, high salt, high pressure, low temperature and oligotrophy, not only adapt to survival of actinomycetes but also enhance molecular diversity of actinomycete secondary metabolites production, thus making marine actinomycetes important sources of marine-based bioactive compounds, especially polyketides. Herein, we summarized the structures and pharmacological activities of polyketides from actinobacteria associated with marine organisms from 2013 to 2019; moreover, the main source species of actinomycetes were discussed as well.

6-(3,4-Di-fluoro-phen-yl)-7,8,13,14-tetra-hydro-dibenzo[,]phenanthridine.

In the title compound, CHFN, the five-fused-ring system is highly puckered and the dihedral angle between the central pyridine ring and pendant di-fluoro-benzene ring is 45.12 (12)°. In the crystal, inversion dimers linked by pairwise weak C-H⋯N hydrogen bonds generate (12) loops and the dimers are further linked by weak C-H⋯F inter-actions to form [01] chains.

Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway.

Human epidemiologic studies and laboratory investigations in animal models suggest that exposure to general anesthetic agents (GAs) have harmful effects on brain development. The mechanism underlying this putative iatrogenic condition is not clear and there are currently no accepted strategies for prophylaxis or treatment. Recent evidence suggests that anesthetics might cause persistent deficits in synaptogenesis by disrupting key events in neurodevelopment.

Genome of Wild Mandarin and Domestication History of Mandarin.

Mandarin (Citrus reticulata) is one of the most important citrus crops worldwide. Its domestication is believed to have occurred in South China, which has been one of the centers of mandarin cultivation for four millennia. We collected natural wild populations of mandarin around the Nanling region and cultivated landraces in the vicinity.

Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.

Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts.

Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer.

Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs.

Nonsense-mediated mRNA decay of collagen -emerging complexity in RNA surveillance mechanisms.

Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved mRNA surveillance system that degrades mRNA transcripts that harbour a premature translation-termination codon (PTC), thus reducing the synthesis of truncated proteins that would otherwise have deleterious effects. Although extensive research has identified a conserved repertoire of NMD factors, these studies have been performed with a restricted set of genes and gene constructs with relatively few exons. As a consequence, NMD mechanisms are poorly understood for genes with large 3' terminal exons, and the applicability of the current models to large multi-exon genes is not clear.

Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme.

Human m-NAD(P)-ME [mitochondrial NAD(P)+-dependent ME (malic enzyme)] is a homotetramer, which is allosterically activated by the binding of fumarate. The fumarate-binding site is located at the dimer interface of the NAD(P)-ME. In the present study, we decipher the functional role of the residue Lys57, which resides at the fumarate-binding site and dimer interface, and thus may be involved in the allosteric regulation and subunit-subunit interaction of the enzyme.

[Pretreatment of supported Wacker catalysts and the determination of palladium and copper].

The supported Wacker catalysts were pretreated with two different methods. Then copper and palladium were determined by inductively coupled plasma atomic emission spectrometry(ICP-AES). The results showed that the best pretreatment method is burning-acid dissolving.

[Determination of molybdenum in supported catalysts by ICP-AES].

The supported Mo catalysts were pretreated using hydrofluoric acid. Then Mo was determined by inductively coupled plasma atomic emission spectrometry(ICP-AES). In the present method, the detection limit of Mo was 8.