Increased Plasma -Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease.

Background: -secretase 1 (BACE1) plays a key role in amyloidogenic pathway and is considered a new mechanism for cerebral small vessel disease (CSVD). We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved in.

Methods And Results: We enrolled 163 participants with CSVD (114 cerebral amyloid angiopathy and 49 hypertensive hemorrhage), and 96 cognitively unimpaired elders and 40 participants with Alzheimer's disease as controls.

Evaluating the Correlation Between Stimulus Frequency Otoacoustic Emission Group Delays and Tuning Sharpness in a Cochlear Model.

Purpose: A theoretical framework based on coherent reflection and filter theory predicts that the phase-gradient delays of stimulus frequency otoacoustic emissions (SFOAEs) are correlated with tuning sharpness in the mammalian cochlea. In this paper, we use a computational model of the cochlea to test this theory and to evaluate how SFOAE phase-gradient delays may be used to estimate the sharpness of cochlear tuning.

Methods: This study is based on a physiologically motivated model which has been previously shown to predict key aspects of cochlear micromechanics.

Low self-control, perceived social support and internet gaming addiction: findings from an ethnicity minority region in China.

Background: Adolescent Internet gaming addiction (IGA) is an pincreasing global concern. Drawing on self-control theory, social support theory, and problem behavior theory, this study aimed to examine the relationships between low self-control, perceived social support, and IGA among Chinese Yi and Non-Yi adolescents, with a focus on the moderating role of perceived social support and ethnic differences.

Methods: A cross-sectional study was conducted among 1,997 adolescents (53.

Psychometric Properties of the Chinese Version of 20-Item Zimbardo Time Perspective Inventory (C-ZTPI-20) in Chinese Adolescent Population.

Background: This study assesses the psychometric properties of the Chinese version of the Zimbardo Time Perspective Inventory (C-ZTPI-20) in an adolescent population.

Methods: The investigation encompasses a sample of 2634 middle school students from China and aims to evaluate the instrument's reliability, structural validity, measurement invariance, criterion validity, and network structure attributes.

Results: First, descriptive analysis revealed satisfactory reliabilities for four out of five C-ZTPI-20 dimensions, with Present Fatalistic (PF) exhibiting relatively low reliability.

Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study.

Background: Cerebral pulsatility is thought to reflect arterial stiffness and downstream microvascular resistance. Although previous studies indicated cerebral pulsatility might closely relate to development of cerebral small vessel disease (SVD), yet evidence remain controversial and longitudinal data are rare.

Objective: We aimed to explore relationships of cerebral pulsatility with severity and progression of various SVD imaging markers among the community-dwelling elderly.

Network structure of the links between extracurricular time-use and delinquent behaviors: Moving forward and beyond linear relations.

Using psychological network analysis, this study explored the heterogeneity of the network structure between extracurricular time-use and delinquency using a nationally representative longitudinal survey of at-school students in China (N = 10,279, 47.3% female, average age 13.6, 91.

Rank, strain, and corruption among Chinese public officials: A general strain theory perspective.

The problem of corruption has long been a societal focus in China. Agnew's general strain theory (GST) offers a good explanation of the drive to engage in corruption; that is, offenders are likely to be driven by various types of strains and engage in corrupt behavior as a coping mechanism. However, whether and how an official's rank moderates the effect of strain on corrupt behavior has yet to be explored.

Multifarious Linkages Between Personality Traits and Psychological Distress During and After COVID-19 Campus Lockdown: A Psychological Network Analysis.

Background: The novel coronavirus disease pandemic is still proliferating and is not expected to end any time soon. Several lockdowns and social distancing measures might be implemented in the future. A growing body of research has explored the effect of personality on individuals' psychological wellbeing during the pandemic.

Social Disconnectedness and Mental Health Problems During the COVID-19 Pandemic in China: A Moderated Mediation Model.

This study aimed to examine the mediating effect of perceived isolation and the moderating effect of COVID-19 related concerns in the relationship between social disconnectedness and mental health problems during the COVID-19 pandemic in China. A cross-sectional online survey of 11,682 Chinese residents were conducted during the COVID-19 outbreak. Conditional process analysis was performed to test the mediating effect of perceived isolation and the moderating effect of COVID-19 related concerns.

Problematic Internet use among residential college students during the COVID-19 lockdown: A social network analysis approach.

Background And Aims: During the COVID-19 lockdown, problematic Internet use (PIU) has become a serious issue among residential college students, who remain physically isolated from off-campus society. This study constructs an integrated model to investigate the influencing mechanisms of internal locus of control (LOC) and objective peer effects.

Methods: Residential college students (n = 494) were surveyed from a single department of a Chinese university.

Experimental Observation of Temporal Pumping in Electromechanical Waveguides.

We experimentally demonstrate temporal pumping of elastic waves in an electromechanical waveguide. Temporal pumping exploits a virtual dimension mapped to time, enabling the generation and control of edge states, typical of two-dimensional systems, in a one-dimensional waveguide. We show experimentally that the temporal modulation of the stiffness drives the transfer of edge states from one boundary of the waveguide to the other.

Perceived Discrimination and Aggression Among Chinese Migrant Adolescents: A Moderated Mediation Model.

Previous research has showed that Chinese rural-to-urban migrant adolescents are at high risk for discrimination, negative emotions, and aggression. However, little is known about how discrimination, negative emotions, and aggression are interrelated and whether social support addressing the emotional needs of the adolescents would moderate the relationship of discrimination to aggression. This study attempts to fill these gaps.

Incident cerebral microbleeds and hypertension defined by the 2017 ACC/AHA Guidelines.

Background: The cut-off for hypertension was lowered to blood pressure (BP) over 130/80 mmHg in the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline. Whether the new definition of hypertension remains a potent risk factor of cerebral microbleeds (CMBs) is uncertain. We aimed to analyze the relationship between the new definition of hypertension and incident CMBs in a 7-year longitudinal community study.

White matter hyperintensities induce distal deficits in the connected fibers.

White matter hyperintensities (WMH) are common in elderly individuals and cause brain network deficits. However, it is still unclear how the global brain network is affected by the focal WMH. We aimed to investigate the diffusion of WMH-related deficits along the connecting white matters (WM).

Acculturation strategies, age at migration, and self-rated health: An empirical study on internal migrants in China.

Berry's bidimensional acculturation model categorizes acculturation status (integration, assimilation, separation, marginalization) by preference toward host and origin cultures. According to Berry's theory, different acculturation strategies yield different health outcomes, and age at migration moderates the relationship between acculturation and health outcome. Previous research has applied this model to understand acculturation's influence on international migrants' health outcomes, but rarely for internal migrants.

Neurofilament light chain predicts risk of recurrence in cerebral amyloid angiopathy-related intracerebral hemorrhage.

Predicting recurrent intracerebral hemorrhage (ICH) related to cerebral amyloid angiopathy (CAA) currently relies on brain images. We aimed to investigate whether blood neurodegenerative biomarkers predict disease severity and ICH recurrence in CAA. We recruited 68 first probable CAA-ICH cases from a Chinese prospective cohort, and 95 controls.

Coercive Parenting and Adolescent Developmental Outcomes: The Moderating Effects of Empathic Concern and Perception of Social Rejection.

Previous studies have identified coercive parenting as a prevalent parenting style in Chinese society. They suggested that this style of parenting could promote prosocial behavior and school commitment when combined with close monitoring and proper training, but it could also undermine mental health. This study critically examines these claims.

White matter hyperintensities associated with progression of cerebral small vessel disease: a 7-year Chinese urban community study.

We aimed to explore the role of white matter hyperintensities (WMH) in progression of cerebral small vessel disease (CSVD) in an urban community in China over a period of 7 years, and to investigate associations between WMH volume (baseline and progression) and cognitive impairment. CSVD markers and neuropsychological tests at baseline and follow-up of 191 participants of the Shanghai Aging Study (SAS) were assessed. WMH volume were assessed by automatic segmentation based on U-net model.

A Longitudinal Study of Authoritative Parenting, Juvenile Delinquency and Crime Victimization among Chinese Adolescents.

Empirical research on the relationship between authoritative parenting and crime victimization has been sparse, although this style of parenting has been identified as an effective parenting practice for inhibiting offending behavior among children and adolescents. The current research aims at filling this gap by examining the influences of authoritative parenting on juvenile delinquency and crime victimization, as well as the mechanisms connecting the processes. Using two-wave survey data collected from a probability sample of 1066 Chinese adolescents, the current study employed a structural equation modeling analysis to test the relationships.

Social integration, perceived stress, locus of control, and psychological wellbeing among chinese emerging adult migrants: A conditional process analysis.

Background: This study investigated the underlying determinants of the relationship between social integration and three dimensions of psychological wellbeing in a nationally representative sample of emerging adult migrants in China.

Methods: Data on 6,084 migrants aged 18-29 years in the 2014 China Migrants Dynamic Survey were analyzed. A conditional process analysis tested hypotheses regarding the influence of social integration on self-rated health, life satisfaction, and mental illness.

Post-Traumatic Growth Following Exposure to Memorial Reports of the 5.12 Wenchuan Earthquake: The Moderating Roles of Self-Esteem and Long-Term PTSD Symptoms.

Media exposure during a traumatic event has been found to be associated with negative psychological consequences. However, the post-disaster role of the mass media and the possible positive psychological consequences of media exposure has received less attention. In the present study, we hypothesized that exposure to memorial media reports would lead to improved post-traumatic growth (PTG).

The Spillover Mechanisms Linking Family Conflicts and Juvenile Delinquency Among Chinese Adolescents.

The mechanisms through which conflicting parental relationship and parenting practices influence adolescent antisocial behavior have not been adequately understood. To bring more understanding to the mechanisms, this study investigates how marital discord interrelates with interparental inconsistency in parenting practices, and how these family conditions influence juvenile delinquency through their spillover effects on mental health problems, parental attachment and delinquent peer association among Chinese adolescents. Findings obtained from a structural equation modeling analysis of survey data collected from a probability sample of 2,496 adolescents (mean age = 15.

Time-Periodic Stiffness Modulation in Elastic Metamaterials for Selective Wave Filtering: Theory and Experiment.

Elastic waveguides with time-modulated stiffness feature a frequency-periodic dispersion spectrum, where branches merge at multiple integers of half the modulation frequency and over a finite wave number range. In this range, frequency becomes complex, with its real part remaining constant. The vanishing group velocity associated with these flat bands leads to frequency-selective reflection at an interface between a nonmodulated medium and a time-modulated one, which converts a broadband input into a narrow-band output centered at the half modulation frequency.

Curvilinear relationship between disaster exposure and psychological growth:10 years after the Wenchuan earthquake.

The extent of disaster exposure is a crucial predictor of both negative and constructive changes influenced by natural disasters. Posttraumatic growth (PTG) is the typical psychological growth that is defined by significant changes for the better in self-view, relationships, and life philosophy as a result of exposure to a traumatic incident. However, findings of previous studies examining the effects of disaster exposure on PTG are inconsistent.