Constructing Ru-CoP Lewis Acid-Base Pairs to Prompt Hydrogen Evolution Reaction in Alkaline Seawater Electrolyte.

Seawater electrolysis is an ideal approach to generating green hydrogen. Nevertheless, the sluggish kinetics of water dissociation and the detrimental chlorine chemistry environment are serious obstructions for industrial applications. Herein, constructing unique (Co) Lewis acid and (Ru-P) base pair sites in Ru-CoP decorated on nitrogen and phosphorus co-doped carbon (Ru-CoP/NPC) significantly optimizes the energy barrier of water dissociation and enhances the anti-corrosive ability for alkaline seawater splitting.

Interfacial Co-O-Cu bonds prompt electrochemical nitrate reduction to ammonia in neutral electrolyte.

In this work, the formed interfacial Co-O-Cu bonds in Co-doped Cu(OH) (Co-Cu(OH)) sufficiently expose active sites and improve the reaction kinetics. As a result, the optimal Co-Cu(OH) provides an amazing faradaic efficiency (91.6%), high selectivity (93.

Coexistence of small gastrointestinal stromal tumor and pancreatic cancer: A case report and literature review.

Small gastrointestinal stromal tumors (GISTs) are rare and malignant tumors that originate in the mesenchymal tissue. Due to their insidious onset and nonspecific symptoms, they are often misdiagnosed, and are generally detected during the diagnosis and treatment of other diseases. The present case report reviewed the treatment process of a patient with a small GIST coexisting with pancreatic cancer who was admitted to the Yiwu Central Hospital (Yiwu, China) in June 2018.

Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator.

Bromodomain protein 4 (BRD4) is an attractive epigenetic target that regulating diverse cellular processes, and the discovery of dual-target inhibitors including BRD4 is an effective approach in cancer treatment to increase potency and reduce drug resistance. Based on the multifunctional drug development strategy, a series of new derivatives of nitrooxy (ONO) or furoxan (1,2,5-oxadiazole 2-oxide) with BRD4 inhibitor capable of inhibiting BRD4 and simultaneously releasing NO were designed and synthesized. When NO concentrations were measured with Griess reagent under physiological conditions, all compounds released NO at micromolar levels, reaching effective antitumor concentrations.

Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical isolates in Southern China.

Background: species are opportunistic causative agents of superficial and disseminated human infections. Fast and accurate identification and targeted antifungal therapy give help to improve the patients' prognosis.

Objectives: This study aimed to evaluate the effectiveness of matrix-assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) for identification, and investigate the epidemiology and antifungal susceptibility profiles of clinical isolates in Southern China.

Microbiological Profiles of Ocular Fungal Infection at an Ophthalmic Referral Hospital in Southern China: A Ten-Year Retrospective Study.

Purpose: This study aims to assess the testing methods used to detect fungal pathogens as well as the pathogenic profiles and drug susceptibility among fungal isolates from ocular sources collected in a tertiary eye hospital.

Methods: The laboratory test records of patients with suspected ocular fungal infection from January 2010 to December 2019 at a tertiary eye care center in southern China were retrospectively evaluated. The isolated pathogens identified by smear examination and culture combined with microscopy were analyzed.

High expression of C10orf91 and LINC01224 in hepatocellular carcinoma and poor prognosis.

Background: The dysregulation of long non-coding RNAs (lncRNAs) has been implicated roles in the pathogenesis of many human diseases, including hepatic diseases. Several lncRNAs have been associated with the progression of hepatocellular carcinoma (HCC), but their function as diagnostic markers for liver cancer remain to be determined.

Objective: This study aimed to identify the potential diagnostic markers for liver cancer.

Sucralose enhances the susceptibility to dextran sulfate sodium (DSS) induced colitis in mice with changes in gut microbiota.

Sucralose is one of the most widely used artificial sweeteners, free of nutrients and calories. Its approval and uses correlate with many of the worldwide epidemiological changes in inflammatory bowel disease (IBD). Multiple animal studies by us and others showed that sucralose exacerbated ileitis in SAMP1/YitFc mice and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.

Hexadecyltrimethylammonium hydroxide promotes electrocatalytic activity for the oxygen evolution reaction.

The oxygen evolution reaction is an essential factor in many renewable energy technologies, such as water splitting, fuel cells, and metal-air batteries. Here we show a unique solution to improve the oxygen evolution reaction rate by adjusting the electrolyte composition via the introduction of hexadecyltrimethylammonium hydroxide into an alkaline electrolyte. The strong adsorption of hexadecyltrimethylammonium cations on the surface of electrocatalysts provides the increased absolute number of OH ions near the electrocatalyst surface, which effectively promotes the oxygen evolution reaction performance of electrocatalysts, such as FeNiS@FeNiOOH microplatelets and SrBaNiFeO powders.

Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota.

Sucralose is a calorie-free high-intensity artificial sweetener that is widely used in thousands of foods and beverages all over the world. Although it was initially regarded as a safe, inert food additive, its adverse effect on gut microbiota and health has drawn more and more attention as evidence accumulates. Studies by us and others revealed that sucralose exacerbated gut damage and inflammation in animal models for inflammatory bowel disease (IBD), including those for both ulcerative colitis, and Crohn's disease.

The Prevalence of and in Cylindrical Dandruff Patients.

Purpose: To compare the prevalence of and factors associated with and in patients with cylindrical dandruff (CD group) and healthy controls.

Methods: Eyelashes were taken from 1680 patients with CD and 1700 healthy controls in China from March 2015 to May 2017. All patients underwent a complete eye examination, and spp.

Microbiological Screening of Hypothermic Preserved Donor Corneas in Keratoplasty.

To determine the prevalence, risk factors and microbial profiles of donor corneal contamination and its association with postoperative infection. 1348 hypothermic preserved donor corneas were screened during keratoplasty to assess the impacts of donor age, gender, cause of death and corneal preservation time on the contamination risk. The microbial spectrum and antibiotic sensitivity of causative microorganisms and the prognostic role of corneoscleral rim cultures were analyzed.

Plasmonic Pt nanoparticles-TiO hierarchical nano-architecture as a visible light photocatalyst for water splitting.

Visible light-driven water splitting (VLWS) into hydrogen and oxygen is attractive and depends on efficient photocatalysts. Herein, we demonstrate the first exploration of the capability to control the morphology of nanostructured TiO in conjunction with the choice of a suitable plasmonic metal (PM) to fabricate novel photocatalysts that are capable of harvesting visible light for more efficient VL-fuel conversion. This methodology affords us to successful access to the novel plasmonic Pt/TiO-HA (large Pt nanoparticles (NPs) supported on TiO hierarchical nano-architecture (TiO-HA)) photocatalysts that exhibit plasmon absorption in the visible range and consequent outstanding activity and durability for VLWS.

Branched Pd@Rh core@shell nanocrystals with exposed Rh {100} facets: an effective electrocatalyst for hydrazine electro-oxidation.

Shape control of noble metal (NM) nanocrystals (NCs) is of great importance for improving their electrocatalytic performance. In this report, branched Pd@Rh core@shell NCs that have right square prism-like arms with preferential exposure of Rh {100} facets (denoted as b-Pd@Rh-NCs thereafter) are synthesized and utilized as an electrocatalyst for the hydrazine electrooxidation (HEO) in acidic and alkaline electrolytes. The b-Pd@Rh-NCs are obtained by the heteroepitaxial growth of Rh on the pre-formed branched Pd NCs (denoted as b-Pd-NCs thereafter) core in the presence of poly(vinyl pyrrolidone) (PVP) and bromide ions.

Using MALDI-TOF-MS to test -infected vitreous.

Purpose: This study aimed to establish a method for testing in the vitreous of endophthalmitis with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), which is simple, fast, and sensitive.

Methods: at different numbers was either mixed with homogenized vitreous or inoculated in porcine eyes for culturing, followed by homogenization. The homogenized vitreous samples, with or without centrifugation, were stained with Gram and Coomassie Blue (CBB) dyes and cultured with blood agar.

Highly Doped Carbon Nanobelts with Ultrahigh Nitrogen Content as High-Performance Supercapacitor Materials.

Nitrogen-doped and nitrogen and oxygen codoped carbon nanobelts (CNBs) (denoted as N-CNBs and N-O-CNBs, respectively) are respectively obtained by pyrolyzing the self-aligned polypyrrole (PPy) NBs and Se@poly(2-methoxy-5-nitroaniline) core@shell nanowires. Particularly, the uniform size, unique nanostructure, and well-defined edges of the PPy NBs result in the uniform size of the doped CNBs with an extraordinarily high N doping level (≈16 at%), especially the very large concentrations of the redox active pyridinic (9 at%) and pyrrolic N (3.5 at%) species.

Bacterial spectrum and resistance patterns in corneal infections at a Tertiary Eye Care Center in South China.

Aim: To investigate the spectrum and antibiotic susceptibility of bacteria isolated from patients with suspected corneal infections in Zhongshan Ophthalmic Center in South China over the past four years retrospectively.

Methods: Totally 1943 corneal scrapes from patients with corneal infections from 2010 to 2013 were cultured and processed using standard microbiological procedures to identify bacterial isolates. Simultaneously, the bacterial isolates were tested for antibiotic susceptibility to 8 antibiotics (ceftazidime, cefuroxim, cefazolin, levofloxacin, ofloxacin, neomycin, tobramycin, chloramphenicol) using the Kirby-Bauer disc diffusion technique.

Bacterial Spectrum and Antibiotic Resistance Patterns of Ocular Infection: Differences between External and Intraocular Diseases.

This study aimed to compare the differences of microbial spectrum and antibiotic resistance patterns between external and intraocular bacterial infections in an eye hospital in South China. A total of 737 bacteria isolates from suspected ocular infections were included in this retrospective study covering the period 2010-2013. The organisms cultured from the ocular surface (cornea, conjunctiva) accounted for the majority of the isolates (82.

Synthesis of branched Pd nanocrystals with tunable structures, their growth mechanism, and enhanced electrocatalytic properties.

Branched Pd nanocrystals (NCs) with tunable architectures are synthesized in high yields (>95%) by simply adjusting the concentration of H2PdCl4 in the presence of fixed amounts of cetyltrimethylammonium bromide (CTAB), L-ascorbic acid (L-AA), and CuBr2(-) that is produced by reducing CuBr2 with L-AA. The as-synthesized branched Pd NCs have long, straight branches with thin diameters. At the same time, the growth process of the branched Pd NCs is monitored, which provides mechanistic insights for the branching growth of Pd NCs.

Solution-phase hierarchical self-organization of ultralong Se nanowires into diverse macroarchitectures and their enhanced field emission.

A simple solution-phase route was developed for the large-scale synthesis of self-organized, closely packed ultralong single crystalline Se nanowire superstructures with diverse morphologies and macroscopic dimensions even extending over several millimeters. The hierarchical architectures of self-organized Se nanowires were formed by reducing H2SeO4 with a bisubstituted aniline, such as 3,5-dimethoxyaniline, 2,5-dimethoxyaniline, 2,6-dimethoxyaniline, and 2-methoxy-5-nitroaniline under solvothermal conditions. Scanning electron microscopy studies show 100% morphological yield and morphological uniformity of the self-organized hierarchical architectures.

Hollow alloy nanostructures templated by Au nanorods: synthesis, mechanistic insights, and electrocatalytic activity.

A unique methodology having access to Au nanorods (AuNRs)-based hollow alloy nanostructures has been developed. The syntheses and characterization of the hollow Pt-Au nanoalloys with ellipsoidal and cylindrical shapes together with a rattle-type hollow Cu-Au nanoheterostructure are described. Unlike the conventional nanoscale Kirkendall process, the formation of these AuNRs-based hollow nanostructures occurs under extremely mild conditions, indicating a distinctive underlying mechanism.

Large-scale, solution-phase growth of semiconductor nanocrystals into ultralong one-dimensional arrays and study of their electrical properties.

One-dimensional (1D) assemblies of semiconductor nanocrystals (NCs) represent an important kind of 1D nanomaterial system due to their potential for exploring novel and enhanced electronic and photonic performances of devices. Herein, we present mass fabrication of a series of 1D arrays of CdSe and PbSe NCs on a large length scale with ultralong, aligned Se nanowires (NWs) as both the reactant and structure-directing template. The 1D self-assembly patterns are the anchored growth of CdSe quantum dots (QDs) on the surface of Se NWs (i.

Formation of one-dimensional Ag-Au solid solution colloids with Au nanorods as seeds, their alloying mechanisms, and surface plasmon resonances.

In this work, one dimensional (1D) Ag-Au solid solution nanoalloys were synthesized by rapidly diffusing Ag into the preformed Au nanorod (AuNR) seeds at ambient temperature in aqueous solution. By varying the molar ratio of AgCl/AuNR (in gold atoms), two kinds of 1D Ag-Au alloy nanostructures with a narrow size distribution--AgAu nanowires and Ag(33)Au(67) nanorods--could be obtained in high yields when NaCl and polyvinylpyrrolidone (PVP) were used as an additive and capping reagent, respectively. Based on HRTEM imaging combined with a series of control experiments, it is conceivable that vacancy/defect-motivated interdiffusion of Ag and Au atoms coupled with oxidative etching is a crucial stage in the mechanism responsible for this room-temperature alloying process, and the subsequent conjugation of the fused Ag-Au alloyed nanostructures is associated with the formation of the AgAu nanowires.

Shape-tailoring of CuPd nanocrystals for enhancement of electro-catalytic activity in oxygen reduction reaction.

CuPd nanocrystals with different shapes including cubes, truncated cubes, cuboctahedra, irregular polyhedra, and tetrapods, have been synthesized by the modification of reactant concentrations. The electrocatalytic activity of the CuPd nanocubes toward the oxygen reduction reaction (ORR) is the higher than the commercial Pt/C catalyst.