Public Health.

Background: Environmental pollutants, called perfluoroalkyl substances (PFAS) have been linked to adverse cardiometabolic outcomes, immune dysfunction and cancer risk, but their associations with adult cognition are unknown. Nearly everyone in the United States has detectable levels of PFAS in their blood, but our prior work found that Asian Americans have the highest exposure burden. As Asian Americans fastest growing segment of older adults, examination of relationships between serum PFAS concentrations and cognition in Asian Americans urgently needed.

An Optoelectronic Sensing Real-Time Glucose Detection Film Using Photonic Crystal Enhanced Rare Earth Fluorescence and Additive Manufacturing.

In this research, a novel detection method employing rare-earth upconversion nanoparticle (UCNP) as the core, coated with MnO nanosheets is designed, which formed a color and fluorescence dual-responsive UCNP composite material, MnO-modified NaYF:Yb,Tm@NaYF. By enabling both colorimetric and fluorescence methods simultaneously, this composite material allows for the detection of glucose concentration under different conditions, while exhibiting strong resistance to environmental interference, chemical stability, and accuracy. To further enhance the sensitivity of the detection method, a photonic crystals (PCs)-PDMS array where polymethyl methacrylate PCs are deposited onto a substrate composed of PDMS-glass slice with hydrophobic surfaces is developed.

Development of waste silk-based aerogel: for continuous treatment of oily wastewater and thermal insulation.

Biomass-based aerogel with lightweight and high sustainability is desired for various applications such as thermal insulation, self-cleaning, and oil contaminant removal. However, systematic comparison and thorough investigation are required to understand the effects of constituent materials and structures on the application properties of biomass-based aerogels. Herein, the construction of superhydrophobic aerogel with controllable hierarchical structure and great reusability was optimized applying a novel design based on the waste silk-derived microfibrillated fibers and microfibrillated aramid fibers.

Design and synthesis of N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide-based α-glucosidase inhibitors.

This study investigates the design and synthesis of a series of novel selective α-glucosidase inhibitors based on N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide framework, employing a bioisosterism strategy. Among the nineteen newly synthesized analogs, compound 4d9 demonstrated the highest α-glucosidase inhibitory potency (IC = 2.11 μM) when compared to the established inhibitors Acarbose (IC = 327.

Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi.

Resistance in pathogenic fungi necessitates the development of fungicides with new mechanisms of action. The Mps1 MAPK of , the pathogen of rice blast disease, has been shown to be a molecular target for fungicide research. Here, we present compound TAK-733 that interacts with the common docking (CD) site of Mps1 and can be used in combination with ATP-competitive inhibitors.

Assessing the Impact and Cost-Effectiveness of Exposome Interventions on Alzheimer's Disease: A Review of Agent-Based Modeling and Other Data Science Methods for Causal Inference.

The exposome (e.g., totality of environmental exposures) and its role in Alzheimer's Disease and Alzheimer's Disease and Related Dementias (AD/ADRD) are increasingly critical areas of study.

Enzyme-Assisted Solid-Phase Microextraction Coupled with a DNA Nanowalker for Dual-Amplified Detection of Chloramphenicol in Animal-Derived Food Products.

Chloramphenicol (CAP), an aminoalcohol antibiotic, exerts its action on bacterial ribosomes, thereby obstructing protein synthesis. However, the use of CAP in husbandry may lead to its excessive accumulation in animal-derived food products. This presents potential risks to consumer health.

Lewis Acid Promotes Three-Component Cyclization to Construct Dithioxazole Derivatives.

A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-free catalysis, the production of disulfides, good functional group tolerance, and good regioselectivity.

Extreme soil salinity reduces N and P metabolism and related microbial network complexity and community immigration rate.

Soil microbiomes are well known to suffer from the effects of rising salinity. There are, however, no current understandings regarding its specific effects on microbial metabolic functions associated with nitrogen (N) and phosphorus (P) cycling, particularly in the Yellow River Delta (YRD), one of the largest estuaries in the world. This research examined soil microbiomes at 50 sites in the YRD region to analyze their co-occurrence networks and their relationship with N (nitrification, denitrification, dissimilatory, assimilatory, fixation, and mineralization) and P (solubilization, mineralization, transportation, and regulation) metabolism processes.

Applying Latent Variable Models to Estimate Cumulative Exposure Burden to Chemical Mixtures and Identify Latent Exposure Subgroups: A Critical Review and Future Directions.

Environmental mixtures, which reflect joint exposure to multiple environmental agents, are a major focus of environmental health and risk assessment research. Advancements in latent variable modeling and psychometrics can be used to address contemporary questions in environmental mixtures research. In particular, latent variable models can quantify an individual's cumulative exposure burden to mixtures and identify hidden subpopulations with distinct exposure patterns.

Ingenious construction of a magnetic-recyclable photo-Fenton catalyst ZnFeO@MIL-88A(Fe) and its adsorption-degradation activity toward levofloxacin.

Monotonic pore size and particles inseparability of metal-organic frameworks (MOFs) caused serious effects on its light absorption ability and charge separation, restricting its application for antibiotic such as levofloxacin (LEV) degradation in water. In this study, a magnetically detachable nano-photocatalyst (ZnFeO@MIL-88A(Fe)) was synthesized using a simple two-step hydrothermal technique. The morphology and microstructure analyses showed that n-type ZnFeO catalyst particles were efficiently assembled onto the surface of MIL-88A(Fe) crystal.

The effects of work-family conflict, work engagement, and job burnout on self-rated health of public health emergency responders in Jilin Province, China, in the context of the COVID-19.

Introduction: Amid sudden public health crises, preserving the well-being and optimal working states of frontline healthcare professionals is imperative for efficaciously managing the emergences. However, there is a paucity of research investigating the health status of frontline healthcare professionals through the perspective of work-family conflict. This study sought to elucidate the complex interrelations between work-family conflict, work engagement, job burnout, and self-rated health among public health emergency responders within the context of the COVID-19 pandemic.

HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.

Background: Although progress has been made in the treatment of LAUD, the survival rate for patients remains poor. An in-depth grasp of the molecular pathways implicated in LUAD progression is vital for improving diagnosis and treatment strategies. This study aims to explore novel molecular mechanisms driving LUAD progression and identify new potential prognostic biomarkers for LAUD patients.

Understanding the effects of mineralization and structure on the mechanical properties of tendon-bone insertion using mesoscale computational modeling.

Tendon-bone fibrocartilaginous insertion, or enthesis, is a specialized interfacial region that connects tendon and bone, effectively transferring forces while minimizing stress concentrations. Previous studies have shown that insertion features gradient mineralization and branching fiber structure, which are believed to play critical roles in its excellent function. However, the specific structure-function relationship, particularly the effects of mineralization and structure at the mesoscale fiber level on the properties and function of insertion, remains poorly understood.

Higher neighborhood disadvantage is associated with weaker interactions among cardiometabolic drivers.

Background: Adiposity, dysglycemia, and hypertension are metabolic drivers that have causal interactions with each other. However, the effect of neighborhood-level disadvantage on the intensity of interactions among these metabolic drivers has not been studied. The objective of this study is to determine whether the strength of the interplay between these drivers is affected by neighborhood-level disadvantage.

Programmed surface platform orchestrates anti-bacterial ability and time-sequential bone healing for implant-associated infection.

Implant-associated infection (IAI) has become an intractable challenge in clinic. The healing of IAI is a complex physiological process involving a series of spatiotemporal connected events. However, existing titanium-based implants in clinic suffer from poor antibacterial effect and single function.

Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells.

Gamma-delta (γδ) T cell-based cancer immunotherapies represent a promising avenue for cancer treatment. However, their development is challenged by the limited expansion and differentiation of the cells ex vivo. Here we induced the endogenous expansion and activation of γδ T cells through oral administration of garlic-derived nanoparticles (GNPs).

Wearable and Multiplexed Biosensors based on Oxide Field-Effect Transistors.

Wearable sensors designed for continuous, non-invasive monitoring of physicochemical signals are important for portable healthcare. Oxide field-effect transistor (FET)-type biosensors provide high sensitivity and scalability. However, they face challenges in mechanical flexibility, multiplexed sensing of different modules, and the absence of integrated on-site signal processing and wireless transmission functionalities for wearable sensing.

Pan-cancer Analysis Reveals m6A Variation and Cell-specific Regulatory Network in Different Cancer Types.

As the most abundant messenger RNA (mRNA) modification, N6-methyladenosine (m6A) plays a crucial role in RNA fate, impacting cellular and physiological processes in various tumor types. However, our understanding of the role of the m6A methylome in tumor heterogeneity remains limited. Herein, we collected and analyzed m6A methylomes across nine human tissues from 97 m6A sequencing (m6A-seq) and RNA sequencing (RNA-seq) samples.