Bmi-1 alleviates alveolar bone resorption through the regulation of autophagy.

Background: B-cell‑specific Moloney MLV insertion site-1(Bmi-1)is a crucial osteopenic target molecule. The aim of this study is to explore the effects of Bmi-1 on alveolar bone resorption and the underlying mechanisms in vitro and vivo.

Methods: A Bmi-1-knockout (Bmi-1) mouse model was used to investigate the effect of Bmi-1 on alveolar bone metabolism, with micro-computed tomography imaging, histology, and immunohistochemistry staining.

Corrigendum: Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis.

[This corrects the article DOI: 10.3389/fimmu.2023.

Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis.

Introduction: Periodontitis is an inflammatory disease and its molecular mechanisms is not clear. A recently discovered cell death pathway called cuproptosis, may related to the disease.

Methods: The datasets GSE10334 of human periodontitis and control were retrieved from the Gene Expression Omnibus database (GEO) for analysis.

Effects of early aminophylline therapy on clinical outcomes in premature infants.

Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in premature infants.

Method: A retrospective observational cohort of infants weighing <1500 g and <30 weeks of gestational age at Kaohsiung Veterans General Hospital received aminophylline either within the first two days of life (EA, early aminophylline group), after the third day of life (LA, late aminophylline group), or without aminophylline during the first month of life (WA, without aminophylline group).

Role of 1,25-dihydroxyvitamin D in alleviating alveolar bone loss and gingival inflammation in ligature-induced periodontitis.

Objectives: The goal of this study was to assess if endogenous 1,25(OH)D deficiency enhanced, whereas exogenous 1,25(OH)D supplementation alleviated alveolar bone loss and gingival inflammation induced by ligature-induced periodontitis.

Methods: A model of ligature-induced experimental periodontitis was generated in wild-type (WT) and Cyp27b1-knockout (KO) mice on a rescue diet (RD), and un-ligated genotype-matched littermates as control, or in WT mice on a normal diet (ND) with vehicle treatment or 1,25(OH)D treatment, and un-ligated WT littermates as control. Alveolar bone mass and turnover, T cell infiltration and inflammatory cytokines in gingival tissues were examined.

Down-regulation of MBNL1-AS1 contributes to tumorigenesis of NSCLC via sponging miR-135a-5p.

Lung cancer remains a big threat to human health. Growing evidence has reported the crucial regulatory effect of lncRNAs on NSCLC progression. Nevertheless, the detailed function of lncRNA MBNL1-AS1 involved in NSCLC development is poorly known.

Direct formation of small Cu2O nanocubes, octahedra, and octapods for efficient synthesis of triazoles.

In most studies describing the preparation of Cu2O crystals of various morphologies, the particle sizes are normally hundreds of nanometers to micrometers due to rapid particle growth, so they are not exactly nanocrystals. Here we report surfactant-free formation of sub-100 nm Cu2O nanocrystals with systematic shape evolution from cubic to octahedral structures by preparing an aqueous mixture of Cu(OAc)2, NaOH, and N2H4 solution. Adjustment of the hydrazine volume enables the particle shape control.

Aqueous phase synthesis of palladium tripod nanostructures for Sonogashira coupling reactions.

In this work, palladium tripod nanocrystals have been synthesized by mixing an aqueous solution of cetyltrimethylammonium bromide (CTAB) surfactant, Na(2)PdCl(4), copper acetate, and ascorbic acid at 30 °C for 3 h. Addition of a small amount of copper ion source is critical to the formation of these tripods with a pod length reaching 100 nm. The incorporation of Cu atoms into the Pd tripods has been verified.