Self-Adaptive Intelligent Metasurface Cloak System with Integrated Sensing Units.

Metasurfaces, which are ultrathin planar metamaterials arranged in certain global sequences, interact uniquely with the surrounding light field and exhibit unusual effects of light modulation. Many interesting applications have been discovered based on metasurfaces, particularly in invisibility cloaks. However, most invisibility cloaks are limited to working in specific directions.

Portable multimodal platform with carbon nano-onions as colorimetric and fluorescent signal output for trypsin detection.

Multimodal biosensors with independent signaling pathways can self-calibrate and improve the reliability of disease biomarker detection. Herein, a colorimetric-fluorescent dual-mode paper-based biosensor with PAN/Fe(III)-CNOs (FPCs) as core components has been developed, which information is recognized by smartphone and naked eye. Using 1-(2-pyridylazo)-2-naphthol (PAN) as a mediator, Fe(III) is enriched on the surface of carbon nano-onions (CNOs), endowing FPCs with excellent mimetic enzyme activity and photothermal conversion ability, which allows it to output amplified colorimetric signals under laser irradiation.

A photoelectrochemical biosensor based on self-calibration platform of carbon-rich plasmonic probe with near-infrared driving signal amplification.

Exploring the photochemical (PEC) method induced by low-energy light source makes great significance to achieve high stability and accurate analysis. A sensing platform driven by near-infrared (NIR) light was designed by making the biochemically encoded carbon rich plasmonic hybrid (CPH) probe, the peptide@C-MoC. The inherent plasmonic effect of C-MoC CPH can directly absorb NIR light, thus starting effective electronic-hole pairs separation.

Self-reduced MXene-Metal interaction electrochemiluminescence support with synergistic electrocatalytic and photothermal effects for the bimodal detection of ovarian cancer biomarkers.

Novel two-dimensional MXene with unique optical and electrical properties has become a new focus in the field of sensing. In particular, their metallic conductivity, good biocompatibility and high anchoring ability to biomaterials make them attractive candidates. Despite such remarkable properties, there are certain limitations, such as low oxidative stability.

[Present situation and progress of surgical treatment for laryngeal clefts].

At present, there is no unified gold standard for the treatment of laryngeal clefts. Type Ⅰ laryngeal clefts with mild symptoms can be treated conservatively, such as thick diet feeding and using proton pump inhibitor to control reflux, while Ⅱ-Ⅳ laryngeal clefts mostly requires surgical intervention.There are many different surgical methods for the treatment of laryngeal clefts, including injection laryngoplasty, endoscopic surgical repair of laryngeal clefts and open laryngoplasty through anterior cervical approach.

[Application of endoscopic surgical repair through bracing laryngoscope in children with type Ⅲ laryngeal clefts].

To analyze the efficacy of endoscopic surgical repair in the treatment of type Ⅲ laryngeal clefts and to explore the feasibility of the treatment for type Ⅲ laryngeal clefts. The clinical data of 6 children with type Ⅲ laryngeal clefts who underwent endoscopic surgical repair in our department from June 2018 to January 2023 were analyzed retrospectively. The operation was performed under combined intravenous and general anesthesia,preserving the spontaneous breathing of the children.

Mxene quantum dots bipolar electrochemiluminescent platform for hepatitis C virus envelope protein E2 detection.

A burgeoning diversified closed bipolar electrochemiluminescent (d-BPE-ECL) based on photothermal amplification biosensor via the thermophysical and photochemical properties of niobium carbide Mxene quantum dots (NbC MQDs) has been proposed. The device consists of three components: separated intermediate recognition, cathodic catalytic hydrogen evolution reaction (HER) and anodic ECL response channel. Wherein, the recognition compartment was innovatively designed as a temperature-sensitive conductivity modulated interface, and the introduction of photothermal material PDA@NbC MQDs through target mediated rolling circle amplification strategy increases the interface temperature under near-infrared light radiation, thereby enhancing the BPE current and leading to the amplification of the anode ECL signal of NbC MQDs.

Versatile MXene composite probe-mediated homogeneous electrochemiluminescence biosensor with integrated signal transduction and near-infrared modulation strategy for concanavalin A detection.

Based on the highly specific interaction between concanavalin A (Con A) and glucose (Glu), a competitive electrochemiluminescence (ECL) biosensor was constructed for ultrasensitive detection of Con A. Nanocomposites with excellent electrocatalytic and photothermal properties were obtained by covalently bonding zinc oxide quantum dots (ZnO QDs) to vanadium carbide MXene (VC MXene) surfaces. The modification of ZnO QDs hinders the aggregation of VC MXene and increases the catalytic activity of oxygen reduction reaction, thus amplifying the luminol cathodic emission.

Designing Multimodal Informative Sensing with an Exosome-Mediated Signal Coupling Transduction Strategy Based on a Single-Stimulus Multiresponse Recognition Interface.

Given that exosomes released from cancer cells carry various tumor-specific proteins on their surface, they have emerged as a source of biomarkers for cancer diagnosis. However, developing accurate and reliable assays to detect exosomes in the early stages of disease with low abundance and complex systems remains challenging. Here, the prepared PDIG film has the ability to sense multiple signals from a single stimulus, in which the presence of cobalt(II) chloride and deep eutectic solvents (DES) endows PDIG with thermochromic and thermosensitive properties.

Two-phase dual-signal-readout immunosensing platform based on multifunctional carbon nano-onions for ovarian cancer biomarker detection.

In order to detect early tumor markers and gain valuable time for treatment, there is an urgent need to develop a fast, cheap, and ultrasensitive multi-reading sensing platform. Herein, a solid/liquid two-phase dual-output biosensor was explored based on a sensitized sonochemiluminescence (SCL) strategy and a multifunctional carbon nano-onion (CNO) probe. It is clear that ultrasonic radiation caused the formation of hydroxyl radicals (˙OH), triggering the SCL signal of the emitter lucigenin (Luc).

A pressure-colorimetric multimode system with photothermal activated multiple rolling signal amplification for ovarian cancer biomarker detection.

Utilizing the photothermal effect to activate enzyme activity, realize signal conversion and amplification show promising prospects in biosensing. Herein, a pressure-colorimetric multi-mode bio-sensor was proposed through the multiple rolling signal amplification strategy of photothermal control. Under NIR light radiation, the NbC MXene labeled photothermal probe caused notable temperature elevation on a multi-functional signal conversion paper (MSCP), leading to decomposition of thermal responsive element and in-situ formation of NbC MXene/Ag-S hybrid.

Optical and Acoustic Synergetic Sensing Platform Enabled by a Pyrene-Based Conjugated Polymer Self-Circulating Amplified System for Lung Cancer Detection.

A stable and reusable electrochemiluminescent (ECL) signal amplification strategy was proposed through a pyrene-based conjugated polymer (Py-CP) triggered self-circulating enhancement system. Specifically, the delocalized conjugated π-electrons of Py-CPs made it an excellent coreactant to arouse the initial ECL signal improvement of Ru(phen), but the subsequent signal reduction was attributed to the consumption of Py-CPs, in which this stage was called the signal sensitization evoking phase (SSEP). Then, the maximum use of ECL luminescence of Ru(phen) produced in the SSEP was made to irradiate the photosensitizer Py-CPs for in situ producing numerous ·OH, and a stronger and more stable ECL response stage defined as the signal sensitization stabilize phase was reached.

Facile and portable multimodal sensing platform driven by photothermal-controlled release system for biomarker detection.

Portable, maneuverable and reliable versatile-integrated analytical devices are urgently demanded but still extremely challenging to meet the requirements of point-of-care testing in resource-limited areas. Herein, a multifunctional sensing platform with excellent photothermal performance was implanted into the miniature zone of a paper-based electrochemiluminescent (ECL) biosensor for accurate detection of interleukin-6, which could flexibly interconnect the visualized distance and temperature readout with ultrasensitive ECL response. Concretely, the multipurpose MBene and TaSe composites (MBene@TaSe) prepared via self-assembly approach as target-associated photothermal element was introduced in the paper-based analytical device (PAD) and served as multi-signals trigger.

Photothermal enhanced fluorescence quenching of Tb-norfloxacin for ultrasensitive human epididymal 4 detection.

A fluorescence quenching enhanced immunoassay has been developed to achieve ultrasensitive recognition of human epididymal 4 (HE4) modifying the fluorescence quencher. The carboxymethyl cellulose sodium-functionalized NbC MXene nanocomposite (CMC@MXene) was firstly introduced to quench the fluorescence signal of the luminophore Tb-Norfloxacin coordination polymer nanoparticles (Tb-NFX CPNPs). The NbC MXene nanocomposite as fluorescent nanoquencher inhibits the electron transfer between Tb and NFX to quench the fluorescent signal by coordinating the strongly electronegative carboxyl group on CMC with Tb (III) of Tb-NFX complex.

Modular and Noncontact Wireless Detection Platform for Ovarian Cancer Markers: Electrochemiluminescent and Photoacoustic Dual-Signal Output Based on Multiresponse Carbon Nano-Onions.

An electrochemiluminescent (ECL)-photoacoustic (PA) dual-signal output biosensor based on the modular optimization and wireless nature of a bipolar electrode (BPE) was constructed. To further simplify the detection process, the BPE structure was designed as three separate units: anode ECL collection, cathode catalytic amplification, and intermediate functional sensing units. Specifically, the anode unit was placed with Eosin Yellow, a cheap and effective ECL reagent, and the cathode unit was a laser-induced polyoxometalate-graphene electrode, which was helpful to enhance the anode ECL signal.

Dual-readout immunosensor based on multifunctional MXene probe triggers the signal amplification for detection of autoimmune hepatitis marker.

A dual-readout immunosensor coupled with electrochemical impedance and temperature signal was successfully proposed to detect autoimmune hepatitis markers (ASGPR). NbC MXene with excellent conductivity, abundant surface functional groups, and extraordinary photothermal conversion efficiency, was designed to be a multifunctional biological probe, whose specific binding with antigen enhanced steric hindrance to generate electrochemical impedance signal, and at the same time, it had a strong optical response in the near-infrared band to achieve temperature output. In addition, poly(N-isopropyl acrylamide) (PNIPAM) was a temperature-sensitive polymer, which was adopted as the sensing matrix.

Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA): Early diagnosis, treatment and outcomes.

Objective: To describe and summarize the early diagnosis, treatment and outcomes of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA).

Methods: Data from patients with OHVIRA treated at the study centre over the last decade were analysed retrospectively, including demographic characteristics, symptoms, diagnosis, treatment and outcomes. Relevant published literature was also reviewed in this study.

Dual-readout proximity hybridization-regulated and photothermally amplified protein analysis based on MXene nanosheets.

Herein, an ingenious dual-readout sensing platform based on a proximity hybridization-regulated strategy is proposed for protein detection. For the first time, TiC MXene@thionine composites (MXene@Thi) with an excellent photothermal effect not only acted as an amplifier to enhance the electrochemical signal, but were also used as a converter to achieve the temperature readout.

A bio-bar-code photothermal probe triggered multi-signal readout sensing system for nontoxic detection of mycotoxins.

Herein, a photothermal triggered multi-signal readout (MSR) system was innovatively established with great convenience for low-cost and sensitive point-of-care testing (POCT). In this sensing system, an intelligent multi-signal readout interface (MSRI) with multidimensional response-ability to thermal stimulus was developed and utilized as a sensing element. A bio-bar-code photothermal probe peptides@HN-HCNTs acted as a target associated photothermal agent anchored on MSRI via competitive reaction.

Design and application of proximity hybridization-based multiple stimuli-responsive immunosensing platform for ovarian cancer biomarker detection.

The development of convenient and sensitive multi-readout immunoassay is crucial but highly challenged for meeting the demand of exactness and diversity in early clinical diagnosis. Herein, a split-type multiple stimuli-responsive biosensor was outlined combined with the outstanding superiority of luminol probe-based electrochemiluminescence (ECL) strategy, mimicking enzyme-mediated colorimetric system and portable photothermal effect-induced temperature sensing. Especially, versatile MoS nanosheets (MoS NSs) with distinguished property not only acted as dual-promoter to improve the cathodic ECL of luminol because of its good electrocatalytic activity for dissolved O and favorable photothermal effect for elevating electrode temperature, but also used as nanozyme to regulate subsequent split-type visual colorimetric sensing due to its peroxidase-like activity for the generation of oxidized 2,2'-azinobis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) in ABTS-HO colorimetric system.